Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Claire E. Gustafson"'
Autor:
Simon Lambert, Wenqiang Cao, Huimin Zhang, Alex Colville, Jie-Yu Liu, Cornelia M. Weyand, Jorg J. Goronzy, Claire E. Gustafson
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
A breakdown in cellular homeostasis is thought to drive naïve T cell aging, however the link between naïve T cell homeostasis and aging in humans is poorly understood. To better address this, we developed a lymphoid organoid system that maintains r
Externí odkaz:
https://doaj.org/article/f3199be1e3fa4f94bf796c88b8c360ea
Autor:
Bin Hu, Rohit R. Jadhav, Claire E. Gustafson, Sabine Le Saux, Zhongde Ye, Xuanying Li, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/1ffebb6d2fb24fafa2db95ebc9619d17
Autor:
Lauren E. Higdon, Claire E. Gustafson, Xuhuai Ji, Malaya K. Sahoo, Benjamin A. Pinsky, Kenneth B. Margulies, Holden T. Maecker, Jorg Goronzy, Jonathan S. Maltzman
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immune function is altered with increasing age. Infection with cytomegalovirus (CMV) accelerates age-related immunological changes resulting in expanded oligoclonal memory CD8 T cell populations with impaired proliferation, signaling, and cytokine pr
Externí odkaz:
https://doaj.org/article/f35b44d9cf494a9289df7e866572a419
Autor:
Bin Hu, Rohit R. Jadhav, Claire E. Gustafson, Sabine Le Saux, Zhongde Ye, Xuanying Li, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Healthy immune aging is in part determined by how well the sizes of naïve T cell compartments are being maintained with advancing age. Throughout adult life, replenishment largely derives from homeostatic proliferation of existing naïve and memory
Externí odkaz:
https://doaj.org/article/76228a1ac19d48b78d55a957577b26da
Autor:
Chulwoo Kim, Rohit R. Jadhav, Claire E. Gustafson, Megan J. Smithey, Alec J. Hirsch, Jennifer L. Uhrlaub, William H. Hildebrand, Janko Nikolich-Žugich, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2202-2216.e5 (2019)
Summary: Generation of protective immunity to infections and vaccinations declines with age. Studies in healthy individuals have implicated reduced miR-181a expression in T cells as contributing to this defect. To understand the impact of miR-181a ex
Externí odkaz:
https://doaj.org/article/a47f08eb0fb546529aaaad1546630684
Autor:
Claire E. Gustafson, Qian Qi, Jessica Hutter-Saunders, Sheena Gupta, Rohit Jadhav, Evan Newell, Holden Maecker, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Aging is associated with an increased susceptibility to infection and a failure to control latent viruses thought to be driven, at least in part, by alterations in CD8 T cell function. The aging T cell repertoire is characterized by an accumulation o
Externí odkaz:
https://doaj.org/article/894ff797b42347779a7b5ac0ff3514a8
Publikováno v:
Curr Opin Virol
T cells are a critical component of the immune system and required for protection against viral and bacterial infections. However, the capacity of these cells to provide sufficient protection declines with age, leading to an increased susceptibility
Autor:
Claire E. Gustafson, Zachary Thomson, Ziyuan He, Elliott Swanson, Katherine Henderson, Mark-Phillip Pebworth, Lauren Y. Okada, Alexander T. Heubeck, Charles R. Roll, Veronica Hernandez, Morgan Weiss, Palak C. Genge, Julian Reading, Josephine R. Giles, Sasikanth Manne, Jeanette Dougherty, CJ Jasen, Allison R. Greenplate, Lynne A. Becker, Lucas T. Graybuck, Suhas V. Vasaikar, Gregory L. Szeto, Adam K. Savage, Cate Speake, Jane H. Buckner, Xiao-jun Li, Troy R. Torgerson, E. John Wherry, Thomas F. Bumol, Laura A. Vella, Sarah E. Henrickson, Peter J. Skene
The naive T cell compartment undergoes multiple changes across age that associate with altered susceptibility to infection and autoimmunity. In addition to the acquisition of naive-like memory T cell subsets, mouse studies describe substantial molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510ab66e66b266ad28cf5b58559c3b29
https://doi.org/10.1101/2022.10.04.510869
https://doi.org/10.1101/2022.10.04.510869
Publikováno v:
Science Immunology. 6
A unique subset of Gremlin1-expressing fibroblastic reticular cells mediate cDC homeostasis and functionality within lymph nodes.
Autor:
Claire E. Gustafson
Publikováno v:
Advances in geriatric medicine and research
Naive T cells are critical for protection against emerging viral and bacterial infections. However, the ability of these cells to elicit effective long-term immune responses declines with age and contributes to increased disease susceptibility in old