Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Claire E Schaar"'
Autor:
Megan M Senchuk, Dylan J Dues, Claire E Schaar, Benjamin K Johnson, Zachary B Madaj, Megan J Bowman, Mary E Winn, Jeremy M Van Raamsdonk
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007268 (2018)
Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (clk-1, isp-1 and nuo-6) to identify overlapping genetic pathways
Externí odkaz:
https://doaj.org/article/84849ea4bb5a44bab5fc831bee13076d
Autor:
Claire E Schaar, Dylan J Dues, Katie K Spielbauer, Emily Machiela, Jason F Cooper, Megan Senchuk, Siegfried Hekimi, Jeremy M Van Raamsdonk
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004972 (2015)
Reactive oxygen species (ROS) are highly reactive, oxygen-containing molecules that can cause molecular damage within the cell. While the accumulation of ROS-mediated damage is widely believed to be one of the main causes of aging, ROS also act in si
Externí odkaz:
https://doaj.org/article/a434ee52eb734619b7a9cd5eacfefa8f
Autor:
Mary E. Winn, Claire E. Schaar, Megan J. Bowman, Dylan J. Dues, Megan M. Senchuk, Benjamin K. Johnson, Jeremy M. Van Raamsdonk
Publikováno v:
Free Radical Biology and Medicine. 108:362-373
Mutations affecting components of the mitochondrial electron transport chain have been shown to increase lifespan in multiple species including the worm Caenorhabditis elegans. While it was originally proposed that decreased generation of reactive ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fa45555c4f1ee4810101d77e5bc1a0
https://doi.org/10.1016/j.freeradbiomed.2017.04.004
https://doi.org/10.1016/j.freeradbiomed.2017.04.004
Autor:
Jason F. Cooper, Emily Machiela, Heather DeJonge, Leira Lew, Ziyun Wu, Benjamin K. Johnson, T. Keith Blackwell, Megan M. Senchuk, Jeremy M. Van Raamsdonk, Claire E. Schaar, Dylan J. Dues
Publikováno v:
BMC Biology
BMC Biology, Vol 16, Iss 1, Pp 1-19 (2018)
BMC Biology, Vol 16, Iss 1, Pp 1-19 (2018)
Background The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria. This pathway has been proposed to influence lifespan, with studies suggesting that mitoUPR acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c129219a756cb8dc04eb3c2df044a4
http://europepmc.org/articles/PMC6298126
http://europepmc.org/articles/PMC6298126
Autor:
Jeremy M. Van Raamsdonk, Alexis Bergsma, Dylan J. Dues, Claire E. Schaar, Megan M. Senchuk, Emily K. Andrews
Publikováno v:
Aging (Albany NY)
In this work, we examine the relationship between stress resistance and aging. We find that resistance to multiple types of stress peaks during early adulthood and then declines with age. To dissect the underlying mechanisms, we use C. elegans transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1708acb6251374a57fad9f39576bd1
https://doi.org/10.18632/aging.100939
https://doi.org/10.18632/aging.100939
Autor:
Megan J. Bowman, Megan M. Senchuk, Jeremy M. Van Raamsdonk, Benjamin K. Johnson, Mary E. Winn, Claire E. Schaar, Dylan J. Dues, Zachary Madaj
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 3, p e1007268 (2018)
PLoS Genetics, Vol 14, Iss 3, p e1007268 (2018)
Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (clk-1, isp-1 and nuo-6) to identify overlapping genetic pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9a9715bd0c2cf53908befd5e83147e
https://pubmed.ncbi.nlm.nih.gov/29522556
https://pubmed.ncbi.nlm.nih.gov/29522556
Autor:
Ziyun Wu, Megan M. Senchuk, Dylan J. Dues, Benjamin K. Johnson, Jason F. Cooper, Leira Lew, Emily Machiela, Claire E. Schaar, Heather DeJonge, T. Keith Blackwell, Jeremy M. Van Raamsdonk
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-19 (2018)
Abstract Background The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria. This pathway has been proposed to influence lifespan, with studies suggesting that mit
Externí odkaz:
https://doaj.org/article/3e24ff41be6c49c6bf436862a3ead19b