Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Claire E McCoy"'
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 9, p 3038 (2020)
Multiple Sclerosis (MS) is a chronic, autoimmune condition characterized by demyelinating lesions and axonal degradation. Even though the cause of MS is heterogeneous, it is known that peripheral immune invasion in the central nervous system (CNS) dr
Externí odkaz:
https://doaj.org/article/51ae932559964dc197d9429b6051b9bd
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69090 (2013)
Suppressors of cytokine signalling (SOCS) proteins are classic inhibitors of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. Many cytokines and pathogenic mediators induce expression of SOCS, which act in a negat
Externí odkaz:
https://doaj.org/article/973aebb401324c8ead00e431b857b6df
Autor:
Anthony Ryan, Mark Lynch, Sinead M Smith, Sylvie Amu, Hendrik J Nel, Claire E McCoy, Jennifer K Dowling, Eve Draper, Vincent O'Reilly, Ciara McCarthy, Julie O'Brien, Déirdre Ní Eidhin, Mary J O'Connell, Brian Keogh, Charles O Morton, Thomas R Rogers, Padraic G Fallon, Luke A O'Neill, Dermot Kelleher, Christine E Loscher
Publikováno v:
PLoS Pathogens, Vol 7, Iss 6, p e1002076 (2011)
Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. The aim of this study was t
Externí odkaz:
https://doaj.org/article/6486bcb3a30d4095ab5596eb0047788c
Autor:
Stephen Fitzsimons, María Muñoz-San Martín, Frances Nally, Eugene Dillon, Ifeolutembi A. Fashina, Moritz J. Strowitzki, Lluís Ramió-Torrentà, Jennifer K. Dowling, Chiara De Santi, Claire E. McCoy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 941-959 (2023)
The modulation of macrophage phenotype from a pro-inflammatory to an anti-inflammatory state holds therapeutic potential in the treatment of inflammatory disease. We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regul
Externí odkaz:
https://doaj.org/article/1357adafc21b460497babab7bfbd80f7
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-16 (2023)
Abstract Background Genome-wide association studies (GWAS) have highlighted over 200 autosomal variants associated with multiple sclerosis (MS). However, variants in non-coding regions such as those encoding microRNAs have not been explored thoroughl
Externí odkaz:
https://doaj.org/article/4812792daf64487cbc529f87755aef41
Autor:
Glenn Fitzpatrick, Danielle Nader, Rebecca Watkin, Claire E. McCoy, Gerard F. Curley, Steven W. Kerrigan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The pathophysiology of sepsis and its accompanying hyper-inflammatory response are key events that lead to multi-organ failure and death. A growing body of literature now suggests that the vascular endothelium plays a critical role in driving early e
Externí odkaz:
https://doaj.org/article/7d1ac8e2372648d5bb59257b065d9182
Autor:
Chiara De Santi, Frances K. Nally, Remsha Afzal, Conor P. Duffy, Stephen Fitzsimons, Stephanie L. Annett, Tracy Robson, Jennifer K. Dowling, Sally-Ann Cryan, Claire E. McCoy
Publikováno v:
Molecular Therapy - Nucleic Acids. 29:643-655
Macrophages are plastic cells playing a crucial role in innate immunity. While fundamental in responding to infections, when persistently maintained in a pro-inflammatory state they can initiate and sustain inflammatory diseases. Therefore, a strateg
Autor:
Yong Ni, Thomas A. Kent, Hui-Ling Zhang, Chao Wei, Zhan-Xiang Wang, Claire E. McCoy, Yi Guo, Yong-Ming Zhu, Xian-Yong Zhou, Yuan Qin, Liang Lin, Zhong-Sheng Li
Publikováno v:
Translational Stroke Research
Graphical Abstract Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. Ho
Autor:
Devika Dahiya, Jonathan Smith, Tammy Strickland, Delphi Morris, Cristina Reschke, Tobias Engel, David Henshall, Claire E McCoy, Jennifer K Dowling
Publikováno v:
BioRxiv the preprint server for Biology
bioRxiv
bioRxiv
Hypoxic ischaemic injury (HIE) in the neonatal brain has significant consequences on neurodevelopment and increases the occurrence of neurological deficits in infants. HIE is also a leading cause of neonatal seizures. Therapeutic options for the trea
Autor:
Fidinny I. Hamid, Gavin P. Davey, Paul J. Hertzog, Conor P. Duffy, Tracy Robson, Daniel J. Gough, Nadine Assmann, Katja Dettmer, Ed C. Lavelle, Christoph Hess, Anne M. Curtis, Bryan R.G. Williams, Frances K. Nally, Aoife L. Gorman, Gavin M. Davis, Claire E. McCoy, Glenn R. Bantug, David K. Finlay, Stephanie Annett, Jennifer K. Dowling, Chiara De Santi, Alex M. Liddicoat, Mariana P. Cervantes-Silva, Remsha Afzal, Peter J. Oefner, Linden J. Gearing
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b0faed67a34997f9e8c7dd17348590
https://www.repository.cam.ac.uk/handle/1810/318448
https://www.repository.cam.ac.uk/handle/1810/318448