Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Claire E Hall"'
Autor:
Raphaelle Luisier, Giulia E. Tyzack, Claire E. Hall, Jamie S. Mitchell, Helen Devine, Doaa M. Taha, Bilal Malik, Ione Meyer, Linda Greensmith, Jia Newcombe, Jernej Ule, Nicholas M. Luscombe, Rickie Patani
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Intron retention (IR) can increase protein diversity and function, and yet unregulated IR may be detrimental to cellular health. This study shows that aberrant IR occurs in ALS and finds nuclear loss of an RNA-binding protein called SFPQ as a new mol
Externí odkaz:
https://doaj.org/article/9c63023a8964420da0433bba1c3207ac
Autor:
Giulia E. Tyzack, Claire E. Hall, Christopher R. Sibley, Tomasz Cymes, Serhiy Forostyak, Giulia Carlino, Ione F. Meyer, Giampietro Schiavo, Su-Chun Zhang, George M. Gibbons, Jia Newcombe, Rickie Patani, András Lakatos
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Astrocytes can have protective or detrimental effects on neurons during injury, but the molecular mechanisms that determine these different states are unresolved. Here the authors identify a pathway via neuronal EphB1 that induces neuroprotective sig
Externí odkaz:
https://doaj.org/article/f2e3526b9f5c450291eab266e252c78a
Autor:
Claire E. Hall, Zhi Yao, Minee Choi, Giulia E. Tyzack, Andrea Serio, Raphaelle Luisier, Jasmine Harley, Elisavet Preza, Charlie Arber, Sarah J. Crisp, P. Marc D. Watson, Dimitri M. Kullmann, Andrey Y. Abramov, Selina Wray, Russell Burley, Samantha H.Y. Loh, L. Miguel Martins, Molly M. Stevens, Nicholas M. Luscombe, Christopher R. Sibley, Andras Lakatos, Jernej Ule, Sonia Gandhi, Rickie Patani
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1739-1749 (2017)
Motor neurons (MNs) and astrocytes (ACs) are implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but their interaction and the sequence of molecular events leading to MN death remain unresolved. Here, we optimized directed differen
Externí odkaz:
https://doaj.org/article/550ea2af177d49298d42a25f23b48e54
Autor:
Doaa M Taha, Benjamin E Clarke, Claire E Hall, Giulia E Tyzack, Oliver J Ziff, Linda Greensmith, Bernadett Kalmar, Mhoriam Ahmed, Aftab Alam, Eric P Thelin, Nuria Marco Garcia, Adel Helmy, Christopher R Sibley, Rickie Patani
Publikováno v:
Taha, D, Clarke, B, Hall, C, Tyzack, G, Ziff, O, Greensmith, L, Kalmar, B, Ahmed, M, Alam, A, Thelin, E P, Garcia, N, Helmy, A, Sibley, C R & Patani, R 2022, ' Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis ', Brain, vol. 145, no. 2, pp. 481-489 . https://doi.org/10.1093/brain/awab328
Amyotrophic lateral sclerosis is a rapidly progressive and fatal disease. Although astrocytes are increasingly recognized contributors to the underlying pathogenesis, the cellular autonomy and uniformity of astrocyte reactive transformation in differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c63121cb13970e6ca055888c04649a
https://www.pure.ed.ac.uk/ws/files/251644449/awab328.pdf
https://www.pure.ed.ac.uk/ws/files/251644449/awab328.pdf
Autor:
Jamie S. Mitchell, Peter J. Hutchinson, Rickie Patani, Eric Peter Thelin, Susan Giorgi-Coll, Giulia E. Tyzack, Keri L. H. Carpenter, Adel Helmy, Arvid Frostell, Tamara Tajsic, Claire E. Hall, Aftab Alam
Publikováno v:
Journal of Neurotrauma
Neuroinflammation has been shown to mediate the pathophysiological response following traumatic brain injury (TBI). Accumulating evidence implicates astrocytes as key immune cells within the central nervous system (CNS), displaying both pro- and anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f44e1a34b7bdde985bbfc8f5cb8094
https://www.repository.cam.ac.uk/handle/1810/297249
https://www.repository.cam.ac.uk/handle/1810/297249
Autor:
Eric Peter, Thelin, Claire E, Hall, Kunal, Gupta, Keri L H, Carpenter, Siddharthan, Chandran, Peter J, Hutchinson, Rickie, Patani, Adel, Helmy
Publikováno v:
Journal of Neurotrauma
Cytokine mediated inflammation likely plays an important role in secondary pathology after traumatic brain injury (TBI). The aim of this study was to elucidate secondary cytokine responses in an in vitro enriched (>80%) human stem cell-derived neuron
Autor:
Claire E. Hall, Tamara Tajsic, Klh Carpenter, Adel Helmy, Arvid Frostell, Rickie Patani, Pja Hutchinson, Eric Peter Thelin
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 90:e11.1-e11
ObjectivesThe objective of this study was to investigate how in vitro astrocyte cultures respond to cytokine pro- and anti-inflammatory cytokine concentrations, corresponding to those seen in the aftermath of human TBI, by analysing downstream cytoki
Autor:
Giulia E. Tyzack, Raphaëlle Luisier, Rickie Patani, Nicholas M. Luscombe, Jernej Ule, Claire E. Hall
Publikováno v:
bioRxiv
BiorXiv
BiorXiv
SUMMARYMutations causing amyotrophic lateral sclerosis (ALS) strongly implicate regulators of RNA-processing that are ubiquitously expressed throughout development. To understand the molecular impact of ALS-causing mutations on early neuronal develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f524099ca154ec1fd2e50cbf66673555