Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Claire E, Hills"'
1
Akademický článek
Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury
Autor: Elena Roger, Christos E. Chadjichristos, Panagiotis Kavvadas, Gareth W. Price, Chelsy L. Cliff, Safia Hadjadj, Jessy Renciot, Paul E. Squires, Claire E. Hills
Publikováno v: Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Background Without a viable cure, chronic kidney disease is a global health concern. Inflammatory damage in and around the renal tubules dictates disease severity and is contributed to by multiple cell types. Activated in response to danger
Externí odkaz: https://doaj.org/article/e48577cddf834d8685f737c5c38985e6
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2
Akademický článek
Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease
Autor: Gareth W. Price, Christos E. Chadjichristos, Panagiotis Kavvadas, Sydney C. W. Tang, Wai Han Yiu, Colin R. Green, Joe A. Potter, Eleftherios Siamantouras, Paul E. Squires, Claire E. Hills
Publikováno v: Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichannel-mediated adenosine
Externí odkaz: https://doaj.org/article/cbf3b5a17eb140fdbcaac434c1479c5c
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3
Quantification of bush-cricket acoustic trachea mechanics using Atomic Force Microscopy nanoindentation
Autor: Eleftherios Siamantouras, Charlie Woodrow, Emine Celiker, Darron A. Cullen, Claire E. Hills, Paul E. Squires, Fernando Montealegre-Z
Publikováno v: Acta Biomaterialia. 153:399-410
Derived from the respiratory tracheae, bush-crickets' acoustic tracheae (or ear canals) are hollow tubes evolved to transmit sounds from the external environment to the interior ear. Due to the location of the ears in the forelegs, the acoustic trach
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cc4bf68c8d5cb46a85413aba997fc9
https://doi.org/10.1016/j.actbio.2022.08.056
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5
Blocking connexin 43 hemichannel-mediated ATP release reduces communication within and between tubular epithelial cells and medullary fibroblasts in a model of diabetic nephropathy
Autor: Bethany M. Williams, Chelsy L. Cliff, Isak Demirel, Paul E. Squires, Claire E. Hills
Introduction: Fibrosis of renal tubules is the final common pathway in diabetic nephropathy and develops in the face of tubular injury and fibroblast activation. Aberrant connexin 43 (Cx43) hemichannel activity has been linked to this damage under eu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79dc3ce717fc7d82e8e9cf44873810d5
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6
Akademický článek
Visfatin Reduces Gap Junction Mediated Cell-to-Cell Communication in Proximal Tubule-Derived Epithelial Cells
Autor: Claire E. Hills, Michael I. Kerr, Mark J. Wall, Paul E. Squires
Publikováno v: Cellular Physiology and Biochemistry, Vol 32, Iss 5, Pp 1200-1212 (2013)
Background/Aims: In the current study we examined if the adipocytokine, visfatin, alters connexin-mediated intercellular communication in proximal tubule-derived epithelial cells. Methods: The effects of visfatin (10-200ng/mL) on cell viability and c
Externí odkaz: https://doaj.org/article/f77a76a2689143749b5c4978a4754c28
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7
Connexin‐mediated cell communication in the kidney: A potential therapeutic target for future intervention of diabetic kidney disease?
Autor: Bethany M Williams, Gareth Price, Paul E. Squires, Joe A. Potter, Chelsy L. Cliff, Claire E. Hills
Publikováno v: Experimental Physiology. 105:219-229
The ability of cells to communicate and synchronise their activity is essential for the maintenance of tissue structure, integrity and function. A family of membrane-bound proteins called connexins are largely responsible for mediating the local tran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86519122dca8563e9c3a2afb72275b4
https://doi.org/10.1113/ep087770
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8
Connexin 43: A Target for the Treatment of Inflammation in Secondary Complications of the Kidney and Eye in Diabetes
Autor: Chelsy L. Cliff, Bethany M. Williams, Christos E. Chadjichristos, Ulrik Mouritzen, Paul E. Squires, Claire E. Hills
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 600, p 600 (2022)
International Journal of Molecular Sciences
Of increasing prevalence, diabetes is characterised by elevated blood glucose and chronic inflammation that precedes the onset of multiple secondary complications, including those of the kidney and the eye. As the leading cause of end stage renal dis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e675b01633c627db0e8faaaf25ff2ec
https://www.mdpi.com/1422-0067/23/2/600
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10
Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α2β1 Binding in TGFβ1-Evoked Renal Tubular Epithelial Cells
Autor: Claire E. Hills, Gareth Price, Joe A. Potter, Colin R. Green, Paul E. Squires, Chelsy L. Cliff
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3644, p 3644 (2021)
Chronic Kidney Disease (CKD) is associated with sustained inflammation and progressive fibrosis, changes that have been linked to altered connexin hemichannel-mediated release of adenosine triphosphate (ATP). Kidney fibrosis develops in response to i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee94ad6d48bb11507f20c6f40aff9ed
http://europepmc.org/articles/PMC8038016
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