Treatment Equity in the Immunotherapy Era: Options for Patients with Both Autoimmune Disease and GU Cancers

Autor: Gavin Hui, Claire Drolen, Christopher A. Hannigan, Alexandra Drakaki

Publikováno v: Life, Vol 12, Iss 3, p 360 (2022)

Numerous immunotherapeutic agents, such as immune checkpoint inhibitors (ICIs), have been approved for the treatment of genitourinary (GU) malignancies. While ICIs have improved treatment outcomes and expanded treatment options, they can cause immune

Externí odkaz: https://doaj.org/article/6089f5302b7a4e3db89aaf6feafd2194

Safety and Activity of Immune Checkpoint Inhibitors in People Living With HIV and Cancer: A Real-World Report From the Cancer Therapy Using Checkpoint Inhibitors in People Living With HIV-International (CATCH-IT) Consortium

Autor: Talal El Zarif, Amin H. Nassar, Elio Adib, Bailey G. Fitzgerald, Jiaming Huang, Tarek H. Mouhieddine, Paul G. Rubinstein, Taylor Nonato, Rana R. McKay, Mingjia Li, Arjun Mittra, Dwight H. Owen, Robert A. Baiocchi, Michael Lorentsen, Christopher Dittus, Nazli Dizman, Adewunmi Falohun, Noha Abdel-Wahab, Adi Diab, Anand Bankapur, Alexandra Reed, Chul Kim, Aakriti Arora, Neil J. Shah, Edward El-Am, Elie Kozaily, Wassim Abdallah, Ahmad Al-Hader, Batool Abu Ghazal, Anwaar Saeed, Claire Drolen, Melissa G. Lechner, Alexandra Drakaki, Javier Baena, Caroline A. Nebhan, Tarek Haykal, Michael A. Morse, Alessio Cortellini, David J. Pinato, Alessia Dalla Pria, Evan Hall, Veli Bakalov, Nathan Bahary, Aarthi Rajkumar, Ankit Mangla, Vishal Shah, Parminder Singh, Frank Aboubakar Nana, Nerea Lopetegui-Lia, Danai Dima, Ryan W. Dobbs, Pauline Funchain, Rabia Saleem, Rachel Woodford, Georgina V. Long, Alexander M. Menzies, Carlo Genova, Giulia Barletta, Sonam Puri, Vaia Florou, Dame Idossa, Maristella Saponara, Paola Queirolo, Giuseppe Lamberti, Alfredo Addeo, Melissa Bersanelli, Dory Freeman, Wanling Xie, Erin G. Reid, Elizabeth Y. Chiao, Elad Sharon, Douglas B. Johnson, Ramya Ramaswami, Mark Bower, Brinda Emu, Thomas U. Marron, Toni K. Choueiri, Lindsey R. Baden, Kathryn Lurain, Guru P. Sonpavde, Abdul Rafeh Naqash

Publikováno v: Journal of Clinical Oncology.

PURPOSE Compared with people living without HIV (PWOH), people living with HIV (PWH) and cancer have traditionally been excluded from immune checkpoint inhibitor (ICI) trials. Furthermore, there is a paucity of real-world data on the use of ICIs in P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dd2df1f220f7a099fa94544d9c68975
https://doi.org/10.1200/jco.22.02459

437 Safety and efficacy of immune checkpoint inhibitors (ICI) in patients living with HIV (PLWH) and metastatic non-small cell lung cancer (NSCLC): a matched cohort study from the international CATCH-IT consortium

Autor: Talal El Zarif, Amin Nassar, Elio Adib, Bailey Fitzgerald, Jiaming Huang, Tarek Mouhieddine, Taylor Nonato, Rana McKay, Mingjia Li, Arjun Mittra, Dwight Owen, Michael Lorentsen, Christopher Dittus, Nazli Dizman, Brinda Emu, Adewunmi Falohun, Noha Abdel-Wahab, Anand Bankapur, Alexandra Reed, Ryan Dobbs, Chul Kim, Aakriti Arora, Neil Shah, Edward El-Am, Elie Kozaily, Wassim Abdallah, Ahmad Al-Hader, Batool Abu Ghazal, Anwaar Saeed, Claire Drolen, Melissa Lechner, Javier Espinar, Caroline Nebhan, Douglas Johnson, Tarek Haykal, Michael Morse, Alessio Cortellini, David Pinato, Alessia Dalla Pria, Mark Bower, Evan Hall, Veli Bakalov, Nathan Bahary, Aarthi Rajkumar, Ankit Mangla, Vishal Shah, Parminder Singh, Frank Aboubakar Nana, Nerea Lopetegui Lia, Danai Dima, Pauline Funchain, Rabia Saleem, Rachel Woodford, Georgina Long AO, Alexander Menzies, Carlo Genova, Giulia Barletta, Sonam Puri, Vaia Florou, Dame Idossa, Paola Queirolo, Giuseppe Lamberti, Alfredo Addeo, Melissa Bersanelli, Dory Freeman, Wanling Xie, Ramya Ramaswami, Thomas Marron, Toni Choueiri, Kathryn Lurain, Lindsey Baden, Guru Sonpavde, Abdul Rafeh Naqash

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ac4564d72a4bcbb792f33dda835db61
https://doi.org/10.1136/jitc-2022-sitc2022.0437

Pan-cancer (ca) analysis of the safety and efficacy of immune checkpoint inhibitors (ICI) in patients (pts) living with HIV (PLWH): Results from the international CATCH-IT consortium

Autor: Talal El Zarif, Amin Nassar, Elio Adib, Jiaming Huang, Rana R. McKay, Ryan Dobbs, Nazli Dizman, Claire Drolen, Elie Kozaily, Anwaar Saeed, Caroline Nebhan, Michael Lorentsen, Javier Baena, Alessia Dalla Pria, Lindsey Baden, Ramya Ramaswami, Toni K. Choueiri, Kathryn Anne Lurain, Guru P. Sonpavde, Abdul Rafeh Naqash

Publikováno v: Journal of Clinical Oncology. 40:2649-2649

2649 Background: PLWH and ca are inadequately represented in clinical trials evaluating ICI especially in the setting of low CD4 counts (ct) and elevated HIV viral loads (VL). We assembled an international cohort of PLWH and ca treated with ICI to ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d28aab5b0599b3344d6c4635f0181e8
https://doi.org/10.1200/jco.2022.40.16_suppl.2649

pH-Driven Mechanistic Switching from Electron Transfer to Energy Transfer between [Ru(bpy)

Autor: Claire, Drolen, Eric, Conklin, Stephen J, Hetterich, Aditi, Krishnamurthy, Gabriel A, Andrade, John L, Dimeglio, Maxwell I, Martin, Linh K, Tran, Glenn P A, Yap, Joel, Rosenthal, Elizabeth R, Young

Publikováno v: Journal of the American Chemical Society. 140(32)

The metal-to-ligand charge transfer excited states of [Ru(bpy)(3)](2+) (bpy = 2,2′-bipyridine) may be deactivated via energy transfer or electron transfer with ferrocene derivatives in aqueous conditions. Stern–Volmer quenching analysis revealed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::748cd246efcad0c0ec2136b12e81f8e6
https://pubmed.ncbi.nlm.nih.gov/30070469