Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Claire Dobson"'
Autor:
Darren J. Schofield, Jennifer Percival-Alwyn, Mateusz Rytelewski, John Hood, Raymond Rothstein, Leslie Wetzel, Kelly McGlinchey, Grace Adjei, Amanda Watkins, LeeAnn Machiesky, Weimin Chen, John Andrews, Maria Groves, Michelle Morrow, Ross A. Stewart, Andrew Leinster, Robert W. Wilkinson, Scott A. Hammond, Nadia Luheshi, Claire Dobson, Michael Oberst
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Preclinical studies of PD-L1 and CTLA-4 blockade have relied heavily on mouse syngeneic tumor models with intact immune systems, which facilitate dissection of immunosuppressive mechanisms in the tumor microenvironment. Commercially developed monoclo
Externí odkaz:
https://doaj.org/article/5b7084f79f5a4c06ad3eff39bdaa115c
Autor:
Darren J. Schofield, Lorraine Irving, Laura Calo, Anna Bogstedt, Gareth Rees, Annalisa Nuccitelli, Rajesh Narwal, Marcella Petrone, Jennifer Roberts, Lee Brown, Fiona Cusdin, Bhupinder Dosanjh, Christopher Lloyd, Claire Dobson, Ian Gurrell, Graham Fraser, Mary McFarlane, Edward Rockenstein, Brian Spencer, Eliezer Masliah, Maria Grazia Spillantini, Keith Tan, Andrew Billinton, Tris Vaughan, Iain Chessell, Michael S. Perkinton
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
There are no approved drug therapies that can prevent or slow the progression of Parkinson's disease (PD). Accumulation and aggregation of α-synuclein protein is observed throughout the nervous system in PD. α-Synuclein is a core component of Lewy
Externí odkaz:
https://doaj.org/article/a43f225941e34147934ac245763e71a0
Autor:
Jayanth Chandran, Ekram Ahmed Chowdhury, Michael Perkinton, Tanguy Jamier, Daniel Sutton, Shengjia Wu, Claire Dobson, Dhaval K. Shah, Iain Chessell, Guy M. L. Meno-Tetang
Publikováno v:
Gene Therapy. 30:132-141
Challenges in obtaining efficient transduction of brain and spinal cord following systemic AAV delivery have led to alternative administration routes being used in clinical trials that directly infuse the virus into the CNS. However, data comparing d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab71b708c17906eb4522af2651c7ec4
https://doi.org/10.1038/s41434-022-00346-1
https://doi.org/10.1038/s41434-022-00346-1
Autor:
Katerina Koether, Valérie Besnard, Hilary Sandig, Alan Carruthers, Elena Miranda, Sabine Grootenboer-Mignot, Camille Taillé, Sylvie Chevret, Dominique Valeyre, Hilario Nunes, Dominique Israel-Biet, Wei Keat Lim, Vincent Cottin, Dominic Corkill, Claire Dobson, Maria Groves, Franco Ferraro, Edouard Guenzi, Ling Huang, Michal Sulikowski, Arnaud Mailleux, Lynne Anne Murray, Thomas Mustelin, Ian Strickland, Matthew A. Sleeman, Bruno Crestani
Publikováno v:
European Respiratory Journal. 61:2102381
Several reports have highlighted a potential role of autoreactive B-cells and autoantibodies that correlates with increased disease severity in patients with idiopathic pulmonary fibrosis (IPF). Here we show that patients with IPF have an altered B-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95358d2839982a50572e71334e6b82e4
https://doi.org/10.1183/13993003.02381-2021
https://doi.org/10.1183/13993003.02381-2021
Autor:
Andrey Tovchigrechko, Yasuhiro Ikeda, Claire Dobson, Andrew Park, Susan Wilson, Rebecca A. Halpin, Changshou Gao, Carrie R. Sowers, Albert E. Schmelzer, James H. Kurasawa
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 330-340 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 330-340 (2020)
The recombinant adeno-associated virus (AAV) vector is one of the most utilized viral vectors in gene therapy due to its robust, long-term in vivo transgene expression and low toxicity. One major hurdle for clinical AAV applications is large-scale ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bcde561465c042ac7f700ec6386eef
https://doi.org/10.1016/j.omtm.2020.09.018
https://doi.org/10.1016/j.omtm.2020.09.018
Autor:
Jane Hughes, Iain Chessell, Arjan Snijder, Peter E. Thornton, Maria A T Groves, Bojana Popovic, James Button, Claire Dobson, Tristan J Vaughan, Bruck Taddese, Darren J. Schofield, Trevor Wilkinson, Wendy A Williams, Ling Huang, Jon P. Hatcher, Clare A. Jones, Yoko Shibata, George Thom, Bhupinder Dosanjh, Andy Billinton, Carl I Webster, John E. Linley
Publikováno v:
Pain. 160:1989-2003
P2X4 is a ligand-gated ion channel implicated in neuropathic pain. Drug discovery efforts targeting P2X4 have been unsuccessful largely because of the difficulty in engineering specificity and selectivity. Here, we describe for the first time the gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9866af38e140ef1e2b18bcb9f4825b5b
https://doi.org/10.1097/j.pain.0000000000001587
https://doi.org/10.1097/j.pain.0000000000001587
Autor:
Kelly McGlinchey, Scott A. Hammond, John Hood, Ross Stewart, Grace Adjei, Weimin Chen, John Andrews, Darren J. Schofield, Robert W. Wilkinson, Maria A T Groves, Leslie Wetzel, Jennifer L. Percival-Alwyn, Michael Oberst, Mateusz Rytelewski, LeeAnn Machiesky, Andrew Leinster, Claire Dobson, Nadia Luheshi, Raymond Rothstein, Michelle Morrow, Amanda Watkins
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Preclinical studies of PD-L1 and CTLA-4 blockade have relied heavily on mouse syngeneic tumor models with intact immune systems, which facilitate dissection of immunosuppressive mechanisms in the tumor microenvironment. Commercially developed monoclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c181f5e12c13c7e626244328ad11c7
https://pubmed.ncbi.nlm.nih.gov/33397194
https://pubmed.ncbi.nlm.nih.gov/33397194
Autor:
Ian Gurrell, David Lowne, Frank Porreca, Caroline M. Kopruszinski, Edita Navratilova, Philip Newton, Joanne Arnold, Claire Dobson, Peter E. Thornton, David W. Dodick, Iain Chessell, Juliana Swiokla
Publikováno v:
Cephalalgia : an international journal of headache. 40(14)
Aim Migraine pain is thought to result from activation of meningeal nociceptors that might involve dural mast cell degranulation and release of proteases and pronociceptive mediators. Tryptase, the most abundant dural mast cell protease, has been dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c9ffda909a1eb203b52aad387828c9
https://pubmed.ncbi.nlm.nih.gov/33131305
https://pubmed.ncbi.nlm.nih.gov/33131305
Autor:
Stephen Blackmore, Kathy Mulgrew, Fiona Cusdin, Suneetha B. Thomas, Elaine M. Hurt, Claire Dobson, Emily Brannigan, James Moynihan, Roger Bradley Dodd, Anna Gudny Sigurdardottir, Rajesh Kumar, Peter Cariuk, Mark Cobbold
Publikováno v:
Cancer Research. 81:1828-1828
Immunotherapy has revolutionized patient care, however, the majority of patients with cancer still do not benefit from this treatment modality. This is due to many factors, including a complex tumor microenvironment (TME) that has too few functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6282b0600acdfc6128132eb0b11a028
https://doi.org/10.1158/1538-7445.am2021-1828
https://doi.org/10.1158/1538-7445.am2021-1828
Autor:
David Hargeaves, Elizabeth England, Robert M. Woods, Michael Fung, Caroline Colley, Paul Warrener, Liz Flavell, Sudharsan Sridharan, Judit E. Debreczeni, Jessica Bonnell, Claire Dobson, Jingying Zha, Bryan M. Edwards, Ling-Ling An, Laura Eghobamien, Ulf Sivars, Joanne Arnold, Jonathan Renshaw, Bojana Popovic, Kate F. Wickson, Tristan J. Vaughan, Trevor Wilkinson
Publikováno v:
mAbs
'mAbs ', vol: 10, pages: 104-117 (2018)
'mAbs ', vol: 10, pages: 104-117 (2018)
C5a is a potent anaphylatoxin that modulates inflammation through the C5aR1 and C5aR2 receptors. The molecular interactions between C5a–C5aR1 receptor are well defined, whereas C5a–C5aR2 receptor interactions are poorly understood. Here, we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3b26c96696e2eb620d74383a366038
http://europepmc.org/articles/PMC5800367
http://europepmc.org/articles/PMC5800367