Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Claire D, Clelland"'
Autor:
Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Giovanni Aviles, Claire D. Clelland, Lihong Zhan, Joe C. Udeochu, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan, Martin Kampmann
Publikováno v:
Nature neuroscience, vol 25, iss 9
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacd0dd4f4f4a2c727da14efed73b6fb
https://escholarship.org/uc/item/00b6v7cg
https://escholarship.org/uc/item/00b6v7cg
Autor:
Nina M, Dräger, Sydney M, Sattler, Cindy Tzu-Ling, Huang, Olivia M, Teter, Kun, Leng, Sayed Hadi, Hashemi, Jason, Hong, Giovanni, Aviles, Claire D, Clelland, Lihong, Zhan, Joe C, Udeochu, Lay, Kodama, Andrew B, Singleton, Mike A, Nalls, Justin, Ichida, Michael E, Ward, Faraz, Faghri, Li, Gan, Martin, Kampmann
Publikováno v:
Nature neuroscience. 25(9)
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2d21f95b47547b29ccf967a5ceb7717
https://pubmed.ncbi.nlm.nih.gov/35953545
https://pubmed.ncbi.nlm.nih.gov/35953545
Autor:
Jung Hyun Lee, Hye-Jin Kim, Jong Bum Lee, Deok Ho Kim, Mark Bothwell, Changho Chun, Dana S. Kamenz, David L. Mack, Alec S.T. Smith, Claire D. Clelland
Publikováno v:
Biomaterials
Neurons derived from human induced pluripotent stem cells (hiPSCs) are powerful tools for modeling neural pathophysiology and preclinical efficacy/toxicity screening of novel therapeutic compounds. However, human neurons cultured in vitro typically d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0affed46fa9159c51b262deda9513a0d
https://pubmed.ncbi.nlm.nih.gov/33631652
https://pubmed.ncbi.nlm.nih.gov/33631652
Autor:
Joe C. Udeochu, Yungui Zhou, Qingyun Li, David Le, Kenneth S. Kosik, Li Gan, Lu Zhou, Guoqiang Yu, Lihong Zhan, Yaqiao Li, Faten A. Sayed, Claire D. Clelland, Jon Iker Etchegaray, Elmer Guzman, Zuolin Cheng, Lay Kodama
Publikováno v:
Nature neuroscience
Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microgl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baade15bf2e93db65900ae8815be634e
https://pubmed.ncbi.nlm.nih.gov/31873194
https://pubmed.ncbi.nlm.nih.gov/31873194
Autor:
Claire D. Clelland, Fuying Gao, Li Gan, David Le, Connor H. Ludwig, Dimitrios Davalos, Yonatan A. Cooper, Katerina Akassoglou, Maria Telpoukhovskaia, Giovanni Coppola, Yaqiao Li, Lay Kodama, Faten A. Sayed, Lihong Zhan, Yungui Zhou, Axel Hauduc
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Late-onset Alzheimer’s disease is the most common form of dementia. A rare hemizygous variant in a microglial-expressed gene, Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), significantly increases risk for late-onset Alzheim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af1db247fe97a0364fc96261ff549d7
https://pubmed.ncbi.nlm.nih.gov/30232263
https://pubmed.ncbi.nlm.nih.gov/30232263
Autor:
P. Tyers, Faye Begeti, Minee L. Choi, S.Y. Lee, Y.B. Kim, Z.H. Cho, Claire D. Clelland, Grainne O'Keeffe, Roger A. Barker, J.H. Oh
Publikováno v:
Neurobiology of Disease, Vol 66, Iss, Pp 19-27 (2014)
Huntington's disease (HD) is an inherited neurodegenerative disorder that is classically defined by a triad of movement and cognitive and psychiatric abnormalities with a well-established pathology that affects the dopaminergic systems of the brain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b0ad87ef95f2af6c9f32f69c88c479
https://doi.org/10.1016/j.nbd.2014.02.004
https://doi.org/10.1016/j.nbd.2014.02.004
Autor:
J. Iker Etchegaray, David Le, Li Xuan Tan, Li Gan, Yaqiao Li, Nicholas T. Seyfried, Faten A. Sayed, Thomas G. Kukar, Claire D. Clelland, Lihong Zhan, Aparna Lakkaraju, Yungui Zhou, Bruce Conklin, Duc M. Duong, Aradhana Sachdev, Lay Kodama
Publikováno v:
Alzheimer's & Dementia. 15:P1509-P1509
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a13ff1e06465f84c6d2015537f0b9db7
https://doi.org/10.1016/j.jalz.2019.08.057
https://doi.org/10.1016/j.jalz.2019.08.057
Publikováno v:
Cephalalgia : an international journal of headache, vol 34, iss 3
Background Several centers have reported efficacious cluster headache suppression with deep brain stimulation (DBS) of the hypothalamic region using a variety of targets. While the connectivity of some of these targets has individually been studied,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ecfaba99c0573594e8094f3b044c93d
https://doi.org/10.1177/0333102413509431
https://doi.org/10.1177/0333102413509431
Publikováno v:
Surgical Neurology International
Despite advances in surgical techniques and medical therapies, a significant proportion of pituitary adenomas remain endocrinologically active, demonstrate persistent radiographic disease, or recur when followed for long periods of time. While surgic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dcf7d2ff88ac313f372cb83bc0cd24
http://europepmc.org/articles/PMC3400491
http://europepmc.org/articles/PMC3400491
Autor:
Gregory D. Clemenson, Fred H. Gage, Lisa M. Saksida, Alexandra M. C. Fragniere, Minee L. Choi, Roger A. Barker, Timothy J. Bussey, Claire D. Clelland, Carola Romberg, Sebastian Jessberger, P. Tyers
Publikováno v:
Science (New York, N.Y.). 325(5937)
Neurogenesis and Spatial Memory The dentate gyrus of the hippocampus is one of two sites in the brain where new neurons are produced throughout life. Adult-born neurons integrate into the dentate gyrus circuitry and are thought to play a role in lear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f7d78d1f6cf6e62ac72f5fd6717886
https://pubmed.ncbi.nlm.nih.gov/19590004
https://pubmed.ncbi.nlm.nih.gov/19590004