Výsledky vyhledávání - "Claire Crimi"

Universal influenza DNA vaccine encoding conserved CD4+ T cell epitopes protects against lethal viral challenge in HLA-DR transgenic mice

Autor: Aleksandra Marinkovic-Petrovic, Marie-France del Guercio, Drew Hannaman, Jeff Alexander, Erika Assarsson, Scott Southwood, Stephani Stewart, Glenn Ishioka, Les Walker, Alessandro Sette, Mark Newman, Lo Vang, Claire Crimi, Pamuk Bilsel, Jason Botten, Vivek Chitnis

Publikováno v: Vaccine. 28:664-672

The goal of the present study was to design a vaccine that would provide universal protection against infection of humans with diverse influenza A viruses. Accordingly, protein sequences from influenza A virus strains currently in circulation (H1N1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437d9c0e21abd113aa5cf7ff7b3d21f9
https://doi.org/10.1016/j.vaccine.2009.10.103

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Rational Design of a Multiepitope Vaccine Encoding T-Lymphocyte Epitopes for Treatment of Chronic Hepatitis B Virus Infections

Autor: Annegret Van der Aa, Claire Crimi, Scott D. Power, Sidharta Murthy, Alessandro Sette, Lydie Meheus, Jonathan Krakover, Carol Dahlberg, Scott Southwood, Erik Depla, Koen Allosery, Veronique De Brabandere, Manley Huang, Brian D. Livingston, Lilia Maria Babe, Denise M. McKinney, Mark Newman, Ramilla Philip

Publikováno v: Journal of Virology. 82:435-450

Chronic hepatitis B virus (HBV) infection, which occurs in 1 to 5% of adult infections and up to 30% of pediatric infections, is characterized by high levels of viral replication averaging a daily production of about 1011 viral particles, hepatic inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9152141d873834411fd3884acf1ca27
https://doi.org/10.1128/jvi.01505-07

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Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1

Autor: Jeri E. Forster, Claire Crimi, Mark Newman, Brian D. Livingston, Cara C. Wilson, Alessandro Sette, Samantha MaWhinney, Scott Southwood, Michelle Anders, Robert W. Chesnut, Denise M. McKinney

Publikováno v: The Journal of Immunology. 171:5611-5623

Epitope-based vaccines designed to induce CTL responses specific for HIV-1 are being developed as a means for addressing vaccine potency and viral heterogeneity. We identified a set of 21 HLA-A2, HLA-A3, and HLA-B7 restricted supertype epitopes from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486f8fa3629ae6eb63e77f95b53c5938
https://doi.org/10.4049/jimmunol.171.10.5611

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Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines

Autor: Denise M. McKinney, Mark Newman, Brian D. Livingston, Alessandro Sette, Claire Crimi, Robert W. Chesnut

Publikováno v: Vaccine. 19:4652-4660

Experimental DNA vaccines comprised of multiple minimal cytotoxic T lymphocytes (CTL) epitopes can effectively induce broad CTL responses; however, such constructs frequently exhibit significant variation in epitope immunogenicity. Antigenicity assay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72cd800c4b4ae4066b17c81cc51d3c0
https://doi.org/10.1016/s0264-410x(01)00233-x

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Immunization with the HBV core 18–27 epitope elicits CTL responses in humans expressing different HLA-A2 supertype molecules

Autor: Claire Crimi, Robert W. Chesnut, Alessandro Sette, John Sidney, John Fikes, Brian D. Livingston

Publikováno v: Human Immunology. 60:1013-1017

The human leukocyte antigen (HLA)-A2 restricted HBV core 18-27 epitope is immunodominant in the context of HLA-A2.1 and subdominant in the context of the other HLA-A2 supertype molecules, as defined by frequency of recognition by memory cytotoxic T l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856711af6fab390daa50e61e8422298c
https://doi.org/10.1016/s0198-8859(99)00103-2

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Identification of A2-restricted hepatitis C virus-specific cytotoxic T lymphocyte epitopes from conserved regions of the viral genome

Autor: Suzette Stitely, Robert W. Chesnut, David Alazard, Elissa Keogh, A Vitiello, Alessandro Sette, Claire Crimi, John Fikes, Peggy Wentworth, John Sidney, Francis V. Chisari, Howard M. Grey, Nanette C. Wong, Scott Southwood, Esteban Celis, Brian D. Livingston

Publikováno v: International Immunology. 8:651-659

We have focused on conserved regions of the hepatitis C Virus (HCV) genome to identify viral peptides that contain HLA class I binding motifs and bind with high affinity to the corresponding purified HLA molecules. Accordingly, we have identified 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70703b4eeb76b7dac1fc4218933554cc
https://doi.org/10.1093/intimm/8.5.651

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Fine restriction analysis and inhibition of antigen recognition in HLA-DQ-restricted T cells by major histocompatibility complex blockers and T cell receptor antagonists

Autor: Claire Crimi, Alessandro Sette, Horacio M. Serra, Esteban Celis

Publikováno v: European Journal of Immunology. 23:2967-2971

The role of polymorphic residues of the beta chain of human histocompatibility leukocyte antigen-DQw5/w6 in antigen presentation to a hepatitis B surface antigen-specific T cell clone was studied. The results obtained demonstrate that the residue sit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067d30f8316519253866e3539ae98695
https://doi.org/10.1002/eji.1830231136

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Towards prediction of degenerate CTL epitope recognition

Autor: Jessica Nolin, Denise M. McKenney, Juliana M. McElrath, Steven G. Self, Fusheng Li, Claire Crimi, Lawrence Corey, Mark Newman, Uma Malhotra

Publikováno v: Human vaccines. 4(2)

The cellular immune system is characterized by flexibility with respect to epitope recognition at the level of peptide binding to HLA molecules and HLA-peptide complexes to T-cell receptors (TCRs). For epitopes recognized by cytotoxic T-lymphocytes (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d19fdec58a948f969fb0f74ed4b2ea
https://pubmed.ncbi.nlm.nih.gov/18382130

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Class I molecules with similar peptide-binding specificities are the result of both common ancestry and convergent evolution

Autor: Scott Southwood, Christopher M. Walker, Austin L. Hughes, Claire Crimi, John L. Dzuris, Edward J. Collins, Brian D. Livingston, Alessandro Sette, John Sidney

Publikováno v: Immunogenetics. 54(12)

HLA class I molecules can be classified into supertypes associated with overlapping peptide-binding motifs and repertoires. Herein, overlaps in peptide-binding and T-cell recognition repertoires were demonstrated between mouse and human molecules. Si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7518254f367ad013c4526cebb29a3230
https://pubmed.ncbi.nlm.nih.gov/12671733

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In vitro induction of primary, antigen-specific CTL from human peripheral blood mononuclear cells stimulated with synthetic peptides

Autor: Laura P. Hale, Robert W. Chesnut, Van Tsai, Francis V. Chisari, Alessandro Sette, Claire Crimi, Suzette Stitely, Ralph T. Kubo, Howard M. Grey, Horacio Serra, Esteban Celis, David Alazard, Peggy Wentworth, Brian D. Livingston, Marie-France del Guercio, John Fikes

Publikováno v: Molecular immunology. 32(9)

A protocol for in vitro induction of primary, antigen-specific CTL from human peripheral blood mononuclear cells (PBMCs) was developed. Antigen presenting cells (APCs) consisted of Staphylococcus aureus Cowan-I (SAC-I) activated PBMCs treated with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d4d8b25fc9b126349b2800364c8630
https://pubmed.ncbi.nlm.nih.gov/7643853

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