Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Claire Crafter"'
Autor:
Thomas G. Hayhow, Beth Williamson, Mandy Lawson, Natalie Cureton, Erin L. Braybrooke, Andrew Campbell, Rodrigo J. Carbajo, Azadeh Cheraghchi-Bashi, Elisabetta Chiarparin, Coura R. Diène, Charlene Fallan, David I. Fisher, Frederick W. Goldberg, Lorna Hopcroft, Philip Hopcroft, Anne Jackson, Jason G. Kettle, Teresa Klinowska, Ulrike Künzel, Gillian Lamont, Hilary J. Lewis, Gareth Maglennon, Scott Martin, Pablo Morentin Gutierrez, Christopher J. Morrow, Myria Nikolaou, J. Willem M. Nissink, Patrick O’Shea, Radoslaw Polanski, Markus Schade, James S. Scott, Aaron Smith, Judith Weber, Joanne Wilson, Bin Yang, Claire Crafter
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Targeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROT
Externí odkaz:
https://doaj.org/article/ec006f9560824ea494be6041bb1eeb60
Autor:
Larissa S. Carnevalli, Charles Sinclair, Molly A. Taylor, Pablo Morentin Gutierrez, Sophie Langdon, Anna M. L. Coenen-Stass, Lorraine Mooney, Adina Hughes, Laura Jarvis, Anna Staniszewska, Claire Crafter, Ben Sidders, Elizabeth Hardaker, Kevin Hudson, Simon T. Barry
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract PI3K inhibitors with differential selectivity to distinct PI3K isoforms have been tested extensively in clinical trials, largely to target tumor epithelial cells. PI3K signaling also regulates the immune system and inhibition of PI3Kδ modul
Externí odkaz:
https://doaj.org/article/d8dfe19702e54dfe8e8186c3eeb57177
Autor:
Emanuel Gonçalves, Aldo Segura‐Cabrera, Clare Pacini, Gabriele Picco, Fiona M Behan, Patricia Jaaks, Elizabeth A Coker, Donny van derMeer, Andrew Barthorpe, Howard Lightfoot, Tatiana Mironenko, Alexandra Beck, Laura Richardson, Wanjuan Yang, Ermira Lleshi, James Hall, Charlotte Tolley, Caitlin Hall, Iman Mali, Frances Thomas, James Morris, Andrew R Leach, James T Lynch, Ben Sidders, Claire Crafter, Francesco Iorio, Stephen Fawell, Mathew J Garnett
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 7, Pp n/a-n/a (2020)
Abstract Low success rates during drug development are due, in part, to the difficulty of defining drug mechanism‐of‐action and molecular markers of therapeutic activity. Here, we integrated 199,219 drug sensitivity measurements for 397 unique an
Externí odkaz:
https://doaj.org/article/8d3c7a8706894b218dbc302dbd8ec445
Autor:
Amina Zoubeidi, Martin E. Gleave, Daksh Thaper, Soojin Kim, Ladan Fazli, Eliana Beraldi, Barry R. Davies, Claire Crafter, Francois Lamoureux, Christian Thomas
PDF - 138 KB, Effect of AZD5363 on body weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7998d5d6986e0f03b7816d98403f127b
https://doi.org/10.1158/1535-7163.22499205
https://doi.org/10.1158/1535-7163.22499205
Autor:
Sabina C. Cosulich, Jason S. Carroll, Robert McEwen, Igor Chernukhin, Mandy Lawson, Azadeh Cheraghchi-Bashi, Urszula M. Polanska, Anna D. Staniszewska, Larissa S. Carnevalli, Jon O. Curwen, Oona Delpuech, Rasmus Siersbaek, Claire Crafter, Chrysiis Michaloglou
Supplementary Figure S1. Vistusertib (AZD2014) causes a decrease in RB phosphorylation in the absence of cell cycle arrest. Supplementary Figure S2. Different mTOR inhibitors in combination with palbociclib cause a decrease in cell viability. Supplem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2971446864fbedb32439af08aab612
https://doi.org/10.1158/1535-7163.22510243
https://doi.org/10.1158/1535-7163.22510243
Autor:
Emma L. Jenkins, Kenji Tamura, Makoto Kodaira, Justin Lindemann, Michael Zinda, Celina M. D'Cruz, Brendon Ladd, Kelly Jacques, Philippa Dudley, Neil James, Vivien Jacobs, Lyndsey Hanson, Claire Crafter, Armelle Logie, Nin Guan, Barry R. Davies
This file contains the supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88b437d053244183f372efec797de0ef
https://doi.org/10.1158/1535-7163.22506828.v1
https://doi.org/10.1158/1535-7163.22506828.v1
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 73K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9ea91e81a67f3f040a1bb9626f1a13
https://doi.org/10.1158/1535-7163.22498635
https://doi.org/10.1158/1535-7163.22498635
Autor:
Emma L. Jenkins, Kenji Tamura, Makoto Kodaira, Justin Lindemann, Michael Zinda, Celina M. D'Cruz, Brendon Ladd, Kelly Jacques, Philippa Dudley, Neil James, Vivien Jacobs, Lyndsey Hanson, Claire Crafter, Armelle Logie, Nin Guan, Barry R. Davies
Supplementary Figure 1: Expression of signalling proteins in MCF10A-AKT1WT and MCF10A-AKT1E17K cells grown in the presence or absence of doxycycline; Supplementary Figure 2: Colony formation in soft agar using MCF10A cells expressing AKT1E17K, AKT1WT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4a86579c7bb9081f8b8e7bccf696df
https://doi.org/10.1158/1535-7163.22506825.v1
https://doi.org/10.1158/1535-7163.22506825.v1
Autor:
Sabina C. Cosulich, Jason S. Carroll, Robert McEwen, Igor Chernukhin, Mandy Lawson, Azadeh Cheraghchi-Bashi, Urszula M. Polanska, Anna D. Staniszewska, Larissa S. Carnevalli, Jon O. Curwen, Oona Delpuech, Rasmus Siersbaek, Claire Crafter, Chrysiis Michaloglou
The cyclin dependent kinase (CDK)–retinoblastoma (RB)–E2F pathway plays a critical role in the control of cell cycle in estrogen receptor–positive (ER+) breast cancer. Small-molecule inhibitors of CDK4/6 have shown promise in this tumor type in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a430fac5fb19944258d4dc125065e6b
https://doi.org/10.1158/1535-7163.c.6539551.v1
https://doi.org/10.1158/1535-7163.c.6539551.v1
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 84K, Correlation of AZD5363 activity in cell lines from different tumor types with RAS, PIK3CA and PTEN status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26adbc826f9cc85329a52ca84cf29cd2
https://doi.org/10.1158/1535-7163.22498644.v1
https://doi.org/10.1158/1535-7163.22498644.v1