Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Claire Conche"'
Autor:
Luise Westernberg, Claire Conche, Yina Hsing Huang, Stephanie Rigaud, Yisong Deng, Sabine Siegemund, Sayak Mukherjee, Lyn'Al Nosaka, Jayajit Das, Karsten Sauer
Publikováno v:
eLife, Vol 5 (2016)
β-selection is the most pivotal event determining αβ T cell fate. Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation. Besides the pre-TCR, β-selection al
Externí odkaz:
https://doaj.org/article/1ae57ac0454547c3a658659fd48d389b
Autor:
Courtney R. Green, Jeramie D. Watrous, Jorge Moscat, Lester F. Lau, Reginald McNulty, Tatiana Kisseleva, Saskia Reibe, Xiao Liu, Rafael Moranchel, Fatih Ceteci, Shabnam Shalapour, Mahan Najhawan, Darren C. Henstridge, Maria T. Diaz-Meco, Claire Conche, Alison Vrbanac, Peter J. Meikle, Koji Taniguchi, Florian R. Greten, Christian M. Metallo, Giuseppe Di Caro, Michael Karin, Mohit Jain, Mark A. Febbraio, Jelena Todoric, Rob Knight
Publikováno v:
Nature Metabolism. 2:1034-1045
Benign hepatosteatosis, affected by lipid uptake, de novo lipogenesis and fatty acid (FA) oxidation, progresses to non-alcoholic steatohepatitis (NASH) on stress and inflammation. A key macronutrient proposed to increase hepatosteatosis and NASH risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c17e4840bcb241150ea2dd3e10750ea
https://doi.org/10.1038/s42255-020-0261-2
https://doi.org/10.1038/s42255-020-0261-2
Autor:
Claire Conche, Fabian Finkelmeier, Marina Pešić, Adele M Nicolas, Tim W Böttger, Kilian B Kennel, Dominic Denk, Fatih Ceteci, Kathleen Mohs, Esther Engel, Özge Canli, Yasamin Dabiri, Kai-Henrik Peiffer, Stefan Zeuzem, Gabriela Salinas, Thomas Longerich, Huan Yang, Florian R Greten
Publikováno v:
Gut. :gutjnl-2022
ObjectiveInvestigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment.DesignGlutathione peroxidase 4 (GPx4), which is considered the master regulator of ferroptosis, was genetically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91443c5b855e11c49d6113f0477721e4
https://doi.org/10.1136/gutjnl-2022-327909
https://doi.org/10.1136/gutjnl-2022-327909
Autor:
Adele M. Nicolas, Marina Pesic, Esther Engel, Paul K. Ziegler, Markus Diefenhardt, Kilian B. Kennel, Florian Buettner, Claire Conche, Valentina Petrocelli, Eiman Elwakeel, Andreas Weigert, Anna Zinoveva, Maximilian Fleischmann, Björn Häupl, Cem Karakütük, Hanibal Bohnenberger, Mohammed H. Mosa, Lars Kaderali, Jochen Gaedcke, Michael Ghadimi, Franz Rödel, Melek C. Arkan, Thomas Oellerich, Claus Rödel, Emmanouil Fokas, Florian R. Greten
Publikováno v:
Cancer Cell. 40:168-184.e13
Standard cancer therapy targets tumor cells without considering possible damage on the tumor microenvironment that could impair therapy response. In rectal cancer patients we find that inflammatory cancer-associated fibroblasts (iCAFs) are associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d48c19e2fdfaa2ebbbd5862827e394
https://doi.org/10.1016/j.ccell.2022.01.004
https://doi.org/10.1016/j.ccell.2022.01.004
Autor:
Florian R. Greten, Claire Conche
Publikováno v:
Immunity. 49(3)
Fungi represent a significant proportion of the gut microbiota. Aberrant immune responses to fungi are frequently observed in inflammatory bowel diseases (IBD) and colorectal cancer (CRC), and mutations in the fungal sensing pathways are associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de9952821aad72db575adffd471cb2e
https://pubmed.ncbi.nlm.nih.gov/30231985
https://pubmed.ncbi.nlm.nih.gov/30231985
Autor:
Karsten Sauer, Lana Schaffer, Luise Westernberg, Stephanie Rigaud, Sabine Siegemund, Blake Broaten, Claire Conche, Steven R. Head
Publikováno v:
Blood. 125:2786-2797
Tight regulation of hematopoietic stem cell (HSC) homeostasis ensures lifelong hematopoiesis and prevents blood cancers. The mechanisms balancing HSC quiescence with expansion and differentiation into hematopoietic progenitors are incompletely unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede8696cf945ad77c48dcab5c0d88327
https://doi.org/10.1182/blood-2014-06-583187
https://doi.org/10.1182/blood-2014-06-583187
Autor:
Sabine Siegemund, Stephanie Rigaud, Yisong Deng, Lyn'Al Nosaka, Sayak Mukherjee, Luise Westernberg, Yina H. Huang, Claire Conche, Karsten Sauer, Jayajit Das
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
β-selection is the most pivotal event determining αβ T cell fate. Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation. Besides the pre-TCR, β-selection al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abed79c9132e8506708e9315eca7188
http://europepmc.org/articles/PMC4764578
http://europepmc.org/articles/PMC4764578
Publikováno v:
Immunity
Immunity, Elsevier, 2009, 30 (1), pp.33-43. ⟨10.1016/j.immuni.2008.10.020⟩
Immunity, Elsevier, 2009, 30 (1), pp.33-43. ⟨10.1016/j.immuni.2008.10.020⟩
Summary It is well established that sustained increases in cyclic AMP (cAMP) such as those triggered by forskolin inhibit T cell activation. We describe here an unexpected phenomenon: in T cells, a transient cAMP increase triggered by the interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758b14654930b2f09b1c2a2dc0b65c51
Autor:
Karsten Sauer, Claire Conche
Publikováno v:
Molecular and cellular biology. 34(18)
Production of the phosphoinositide lipid phosphatidylinositol (3,4,5)trisphosphate [PI(3,4,5)P3, or PIP3] by class I phosphoinositide 3-kinases (PI3Ks) is a major signaling mechanism whose deregulation contributes to serious diseases, including cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc38634fe8c7b3a9b8aa93048578631
https://pubmed.ncbi.nlm.nih.gov/25047838
https://pubmed.ncbi.nlm.nih.gov/25047838
Autor:
Stephanie Rigaud, Hyun Yong Jin, Luise Westernberg, Kelly Bethel, Karsten Sauer, Sabine Siegemund, Claire Conche, Changchun Xiao
Publikováno v:
Cancer Research. 76:LB-020
Accounting for ∼4% of all cancers in the US, Non-Hodgkin Lymphoma (NHL) is the most prevalent blood cancer. Diffuse large B-cell Lymphoma (DLBCL) is the most common and aggressive type of NHL. Here, we identify inositol-trisphosphate (IP3) 3-kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25cbf0d570ed5a661c17972cf88c65e6
https://doi.org/10.1158/1538-7445.am2016-lb-020
https://doi.org/10.1158/1538-7445.am2016-lb-020