Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Claire Cheyssac"'
1
Pax6 Is a Key Component of Regulated Glucagon Secretion
Autor: Caroline Poisson, Mounia Heddad Masson, Jacques Philippe, Yvan Gosmain, Audrey Guérardel, Claire Cheyssac
Publikováno v: Endocrinology, Vol. 153, No 9 (2012) pp. 4204-15
The Pax6 transcription factor is crucial for pancreatic α-cells. Indeed, Pax6-deficient mouse models are characterized by markedly altered α-cell differentiation. Our objective was to investigate the role of Pax6 in glucagon secretion process. We u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4e08a66a1b2e4c08788194ee66248e
https://doi.org/10.1210/en.2012-1425
Zobrazit plný text záznamu
2
Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion
Autor: Yvan Gosmain, Jacques Philippe, Caroline Poisson, Liora S. Katz, Mounia Heddad Masson, Claire Cheyssac
Publikováno v: Molecular Endocrinology, Vol. 26, No 4 (2012) pp. 696-709
The Pax6 transcription factor is crucial for endocrine cell differentiation and function. Indeed, mutations of Pax6 are associated with a diabetic phenotype and a drastic decrease of insulin-positive cell number. Our aim was to better define the β-c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a58cb8bdd3e490d75964eb100b2896a
https://archive-ouverte.unige.ch/unige:31925
Zobrazit plný text záznamu
3
Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion
Autor: Charna Dibner, Claire Cheyssac, Yvan Gosmain, M. Heddad Masson, Jacques Philippe
Publikováno v: Diabetes, Obesity and Metabolism, Vol. 13 Suppl 1 (2011) pp. 31-8
Diabetes obesity & metabolism
The glucagon gene is expressed in α-cells of the pancreas, L cells of the intestine and the hypothalamus. The determinants of the α-cell-specific expression of the glucagon gene are not fully characterized, although Arx, Pax6 and Foxa2 are critical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9662250ca3fa0f22320257e53babf73d
https://archive-ouverte.unige.ch/unige:25626
Zobrazit plný text záznamu
4
Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function
Autor: Yvan Gosmain, Karim Bouzakri, Jacques Philippe, Aline Mamin, Claire Cheyssac, Eric Marthinet, Liora S. Katz, Audrey Guérardel
Publikováno v: Journal of Biological Chemistry, Vol. 285, No 43 (2010) pp. 33381-33393
The paired box homeodomain Pax6 is crucial for endocrine cell development and function and plays an essential role in glucose homeostasis. Indeed, mutations of Pax6 are associated with diabetic phenotype. Importantly, homozygous mutant mice for Pax6
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc1aa2d1f763da6da98d5890f83bad9
https://archive-ouverte.unige.ch/unige:20973
Zobrazit plný text záznamu
6
PO16 Le facteur de transcription Pax6 représente un composant majeur de la fonctionnalité des cellules alpha-pancréatiques en contrôlant la sécrétion du glucagon
Autor: Caroline Poisson, Jacques Philippe, M. Heddad Masson, Yvan Gosmain, Claire Cheyssac
Publikováno v: Diabetes & Metabolism. 38:A25
Introduction Le diabete de type 2 est principalement caracterise par une insulino-resistance ainsi qu’une alteration de la secretion du glucagon conduisant a une hyperglucagonemie. Nous avons prealablement pu demontrer que le facteur de transcripti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bacf0342de283e71ac0f11ca233a5dab
https://doi.org/10.1016/s1262-3636(12)71078-9
Zobrazit plný text záznamu
7
P159 - Pax6 représente un composant majeur de la fonctionnalité des cellules bêta-pancréatiques en contrôlant l’expression de gènes cruciaux pour la biosynthèse et la sécrétion de l’insuline
Autor: Claire Cheyssac, Yvan Gosmain, Jacques Philippe, M.H. Masson, L.S. Katz
Publikováno v: Diabetes & Metabolism. 37:A72
Introduction Pax6 est un facteur de transcription implique dans le developpement du pancreas endocrine. L’invalidation du gene Pax6 chez la souris est caracterisee principalement par une absence de cellules a glucagon et une forte diminution du nom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f6bb3ff1844939c4b518b90c86a0754
https://doi.org/10.1016/s1262-3636(11)70785-6
Zobrazit plný text záznamu
8
Analysis of common PTPN1gene variants in type 2 diabetes, obesity and associated phenotypes in the French population
Autor: Cécile Lecoeur, Philippe Froguel, Martine Vaxillaire, Michel Marre, Guillaume Charpentier, Beverley Balkau, Amina Bibi, Fernando Gibson, Claire Cheyssac, Aurélie Dechaume
Publikováno v: BMC Medical Genetics, Vol 7, Iss 1, p 44 (2006)
BMC Medical Genetics
BMC Medical Genetics, BioMed Central, 2006, 7, pp.44. ⟨10.1186/1471-2350-7-44⟩
BMC Medical Genetics, 2006, 7, pp.44. ⟨10.1186/1471-2350-7-44⟩
Background The protein tyrosine phosphatase-1B, a negative regulator for insulin and leptin signalling, potentially modulates glucose and energy homeostasis. PTP1B is encoded by the PTPN1 gene located on chromosome 20q13 showing linkage with type 2 d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64af0955eb7ce880cf8c6cbe703a709
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje