Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion

Autor: Yvan Gosmain, Jacques Philippe, Caroline Poisson, Liora S. Katz, Mounia Heddad Masson, Claire Cheyssac

Publikováno v: Molecular Endocrinology, Vol. 26, No 4 (2012) pp. 696-709

The Pax6 transcription factor is crucial for endocrine cell differentiation and function. Indeed, mutations of Pax6 are associated with a diabetic phenotype and a drastic decrease of insulin-positive cell number. Our aim was to better define the β-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a58cb8bdd3e490d75964eb100b2896a
https://archive-ouverte.unige.ch/unige:31925

Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function

Autor: Yvan Gosmain, Karim Bouzakri, Jacques Philippe, Aline Mamin, Claire Cheyssac, Eric Marthinet, Liora S. Katz, Audrey Guérardel

Publikováno v: Journal of Biological Chemistry, Vol. 285, No 43 (2010) pp. 33381-33393

The paired box homeodomain Pax6 is crucial for endocrine cell development and function and plays an essential role in glucose homeostasis. Indeed, mutations of Pax6 are associated with diabetic phenotype. Importantly, homozygous mutant mice for Pax6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc1aa2d1f763da6da98d5890f83bad9
https://archive-ouverte.unige.ch/unige:20973

PO16 Le facteur de transcription Pax6 représente un composant majeur de la fonctionnalité des cellules alpha-pancréatiques en contrôlant la sécrétion du glucagon

Autor: Caroline Poisson, Jacques Philippe, M. Heddad Masson, Yvan Gosmain, Claire Cheyssac

Publikováno v: Diabetes & Metabolism. 38:A25

Introduction Le diabete de type 2 est principalement caracterise par une insulino-resistance ainsi qu’une alteration de la secretion du glucagon conduisant a une hyperglucagonemie. Nous avons prealablement pu demontrer que le facteur de transcripti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bacf0342de283e71ac0f11ca233a5dab
https://doi.org/10.1016/s1262-3636(12)71078-9

Analysis of common PTPN1gene variants in type 2 diabetes, obesity and associated phenotypes in the French population

Autor: Cécile Lecoeur, Philippe Froguel, Martine Vaxillaire, Michel Marre, Guillaume Charpentier, Beverley Balkau, Amina Bibi, Fernando Gibson, Claire Cheyssac, Aurélie Dechaume

Publikováno v: BMC Medical Genetics, Vol 7, Iss 1, p 44 (2006)
BMC Medical Genetics
BMC Medical Genetics, BioMed Central, 2006, 7, pp.44. ⟨10.1186/1471-2350-7-44⟩
BMC Medical Genetics, 2006, 7, pp.44. ⟨10.1186/1471-2350-7-44⟩

Background The protein tyrosine phosphatase-1B, a negative regulator for insulin and leptin signalling, potentially modulates glucose and energy homeostasis. PTP1B is encoded by the PTPN1 gene located on chromosome 20q13 showing linkage with type 2 d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64af0955eb7ce880cf8c6cbe703a709

Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population.

Autor: Cheyssac, Claire¹ claire.cheyssac@good.ibl.fr, Lecoeur, Cécile¹ cecile.lecoeur@good.ibl.fr, Dechaume, Aurélie¹ aurelie.dechaume@good.ibl.fr, Bibi, Amina² a.bibi@imperial.ac.uk, Charpentier, Guillaume³ guillaume.charpentier@chsud-francilien.fr, Balkau, Beverley⁴ balkau@vjf.inserm.fr, Marre, Michel⁵ michel.marre@bch.ap-hop-paris.fr, Froguel, Philippe^1,2 philippe.froguel@good.ibl.fr, Gibson, Fernando² fernando.gibson@imperial.ac.uk, Vaxillaire, Martine¹ martine.vaxillaire@good.ibl.fr

Publikováno v: BMC Medical Genetics. 2006, Vol. 7, p1-10. 10p. 1 Color Photograph, 6 Charts.