TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells

Autor: Ali Youness, Claire Cenac, Berenice Faz-López, Solange Grunenwald, Franck J. Barrat, Julie Chaumeil, José Enrique Mejía, Jean-Charles Guéry

Publikováno v: Biology of Sex Differences, Vol 14, Iss 1, Pp 1-21 (2023)

Abstract Background Human endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of innate immunity and autoimmune pathogenesis. TLR7 and TLR8 are, respectively, encoded by adjacent X-linked g

Externí odkaz: https://doaj.org/article/12a29fbec5934323b640eaaa56e2984a

HIV-1 infection enhances innate function andiTLR7/iexpression in female plasmacytoid dendritic cells

Autor: Flora Abbas, Claire Cenac, Ali Youness, Pascal Azar, Pierre Delobel, Jean-Charles Guéry

Publikováno v: Life science alliance. 5(10)

Plasmacytoid dendritic cells (pDCs) express TLR7, a ssRNA-sensor encoded on the X chromosome, which escapes X chromosome inactivation (XCI) in females. pDCs are specialized in the production of type 1 interferons (IFN-I) through TLR7 activation which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9a7197847ca932b8812a8ec7417d5b
https://pubmed.ncbi.nlm.nih.gov/36271499

Hydroxychloroquine inhibits proteolytic processing of endogenous TLR7 protein in human primary plasmacytoid dendritic cells

Autor: Jean-Charles Guéry, Mariette F. Ducatez, Claire Cenac

Toll-like receptor 7 (TLR7) triggers antiviral immune responses through its capacity to recognize single-stranded RNA. Proteolytic cleavage of TLR7 protein is required for its functional maturation in the endosomal compartment. Structural studies dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5d93b25ab57902c393c847b2157e77
https://doi.org/10.1101/2021.09.14.21263569

TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women

Autor: Jean-Charles Guéry, Jacques Izopet, Asma Essat, Arnoo Shaiykova, Caroline Passaes, Sophie Laffont, Ali Youness, Pascal Azar, Michaela Müller-Trutwin, José E. Mejía, Pierre Delobel, Laurence Meyer, Claire Cenac

Publikováno v: JCI Insight
JCI Insight, American Society for Clinical Investigation, 2020, 5 (12), ⟨10.1172/jci.insight.136047⟩
JCI Insight, American Society for Clinical Investigation, 2020, 5 (12), pp.e136047. ⟨10.1172/jci.insight.136047⟩
JCI Insight, 2020, 5 (12), pp.e136047. ⟨10.1172/jci.insight.136047⟩

International audience; Type I IFN (IFN-I) production by plasmacytoid DCs (pDCs) occurs during acute HIV-1 infection in response to TLR7 stimulation, but the role of pDC-derived IFN-I in controlling or promoting HIV-1 infection is ambiguous. We repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8932b542dcf842ba7049a0070c46a9
https://hal.archives-ouvertes.fr/hal-03012855

Androgen signaling negatively controls group 2 innate lymphoid cells

Autor: Daniel Metzger, Claire Cenac, Gilles Laverny, Eve Blanquart, Jean-Charles Guéry, Sophie Laffont, Magali Savignac, Lucette Pelletier, Cyril Seillet, Jean-Philippe Girard, Gabrielle T. Belz

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, 2017, 214 (6), pp.1581-1592. ⟨10.1084/jem.20161807⟩

At the onset of adolescence, asthma becomes less prevalent in males than in females, suggesting a protective role of male sex hormones. Here, Laffont et al. show that androgens negatively control ILC2 development and ILC2-driven lung inflammation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c23d575b7bd7ef2520b1a00d0ab270
http://europepmc.org/articles/PMC5461006