Výsledky vyhledávání - "Claire Brougham"

A step closer to elastogenesis on demand; Inducing mature elastic fibre deposition in a natural biomaterial scaffold

Autor: Arlyng González-Vázquez, Claire Brougham, Francisco R. Almeida-González, Suzanne M. Mithieux, Anthony S. Weiss, Fergal J. O'Brien

Publikováno v: Articles

Elastic fibres play a key role in bodily functions where fatigue resistance and elastic recovery are necessary while regulating phenotype, proliferation and migration in cells. While in vivo elastic fibres are created at a late foetal stage, a major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec035b2eaad0e74fec4e4234a2e624e8
https://doi.org/10.1016/j.msec.2020.111788

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Freeze-Drying as a Novel Biofabrication Method for Achieving a Controlled Microarchitecture within Large, Complex Natural Biomaterial Scaffolds

Autor: Claire Brougham, Stefan Jockenhoevel, Gerard M. Cooney, Nian Shen, Tanya J. Levingstone, Fergal J. O'Brien, Thomas C. Flanagan

Publikováno v: Advanced Healthcare Materials, 6(21). Wiley
Articles

The biofabrication of large scaffolds from natural biomaterials into complex 3D shapes with controllable microarchitecture remains a major challenge. Freeze-drying (or lyophilization) is a technique used to create bioactive scaffolds with a porous ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06cfb0905172d9ab463358a143d0c70
https://cris.maastrichtuniversity.nl/en/publications/ff163cb0-ba09-4f22-a195-e2028604d18b

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Towards 3D in vitro models for the study of cardiovascular tissues and disease

Autor: Alan J. Ryan, Fergal J. O'Brien, Steven W. Kerrigan, Claire Brougham, Carolina D. Garciarena

Publikováno v: Articles

The field of tissue engineering is developing biomimetic biomaterial scaffolds that are showing increasing therapeutic potential for the repair of cardiovascular tissues. However, a major opportunity exists to use them as 3D in vitro models for the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964d520f0e51cc0429e8d964816763b9
https://pubmed.ncbi.nlm.nih.gov/27117348

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Incorporation of fibrin into a collagen-glycosaminoglycan matrix results in a scaffold with improved mechanical properties and enhanced capacity to resist cell-mediated contraction

Autor: Tanya J. Levingstone, Stefan Jockenhoevel, Fergal J. O'Brien, Thomas C. Flanagan, Claire Brougham

Publikováno v: Acta Biomaterialia, 26, 205-214. Elsevier / Bunge
Articles

Fibrin has many uses as a tissue engineering scaffold, however many in vivo studies have shown a reduction in function resulting from the susceptibility of fibrin to cell-mediated contraction. The overall aim of the present study was to develop and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020100414228eae67ff450b0720da386
https://pubmed.ncbi.nlm.nih.gov/26297884

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The Effect of Physiological Cyclic Stretch on the Cell Morphology, Cell Orientation and Protein Expression of Endothelial Cells

Autor: E. McLucas, Peter E. McHugh, D. O'Mahoney, Claire Brougham, Valerie Barron, Karen M. Coghlan, Catherine Stenson-Cox

Publikováno v: Articles

In vivo, endothelial cells are constantly exposed to pulsatile shear and tensile stresses. The main aim of this study was to design and build a physiological simulator, which reproduced homogenous strain profiles of the tensile strain experienced in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2519929bbf51c9ebfe8407c152ebe4a
https://arrow.tudublin.ie/context/biodevart/article/1007/viewcontent/auto_convert.pdf

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