Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Claire Bouix-Peter"'
Autor:
Qi Tang, Hassan H. Fakih, Mohammad Zain UI Abideen, Samuel R. Hildebrand, Khashayar Afshari, Katherine Y. Gross, Jacquelyn Sousa, Allison S. Maebius, Christina Bartholdy, Pia Pernille Søgaard, Malene Jackerott, Vignesh Hariharan, Ashley Summers, Xueli Fan, Ken Okamura, Kathryn R. Monopoli, David A. Cooper, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, Raymond C. Furgal, Karen Dresser, Sarah J. Winter, Annabelle Biscans, Jane Chuprin, Nazgol-Sadat Haddadi, Shany Sherman, Ümmügülsüm Yıldız-Altay, Mehdi Rashighi, Jillian M. Richmond, Claire Bouix-Peter, Carine Blanchard, Adam Clauss, Julia F. Alterman, Anastasia Khvorova, John E. Harris
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors show distinct efficacy and safety profiles, likely reflecting variable
Externí odkaz:
https://doaj.org/article/4a8cb6635b9d4fb98e9074b6bcb3b50f
Autor:
Qi Tang, Katherine Y. Gross, Hassan H. Fakih, Samuel O. Jackson, Mohammad Zain U.I. Abideen, Kathryn R. Monopoli, Carine Blanchard, Claire Bouix-Peter, Thibaud Portal, John E. Harris, Anastasia Khvorova, Julia F. Alterman
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102117- (2024)
Identifying therapeutic oligonucleotides that are cross-reactive to experimental animal species can dramatically accelerate the process of preclinical development and clinical translation. Here, we identify fully chemically-modified small interfering
Externí odkaz:
https://doaj.org/article/20b9e2482d6e42e2ba4c20b806a408b4
Autor:
Romain Pierre, Anne Brethon, Sylvain A. Jacques, Aurélie Blond, Sandrine Chambon, Sandrine Talano, Catherine Raffin, Branislav Musicki, Claire Bouix-Peter, Loic Tomas, Gilles Ouvry, Rémy Morgentin, Laurent F. Hennequin, Craig S. Harris
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 156-165 (2021)
In our hands, efficient access to the 4-amino-3-carboxamide disubstituted pyridine-2(1H)-one kinase hinge-binder motif proved to be more challenging than anticipated requiring a significant investment in route scouting and optimization. This full pap
Externí odkaz:
https://doaj.org/article/2acdd653d9364f4c95c1ad7741ba07ae
Autor:
Craig S. Harris, Romain Pierre, Rodolphe Vatinel, Jean-Marie Arlabosse, Veronique Parnet, Catherine Raffin, Claire Bouix-Peter, Thibaud Gerfaud, Sebastien Daver, Jean-Guy Boiteau, Branislav Musicki, Guillaume Lafitte, Loïc Tomas, Gilles Ouvry
Publikováno v:
Tetrahedron. 74:5974-5986
During our research looking for novel inverse agonists of RORγt, we identified a potent sulfoximine-based modulator as one of our pre-clinical candidates for the topical treatment for psoriasis. Herein, we describe the various routes we evaluated du
Autor:
Claire Bouix-Peter
Publikováno v:
Chimie, dermo-cosmétique et beauté
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a190745658e2ccdcf1e1c3bd66a8bf
https://doi.org/10.1051/978-2-7598-2078-8.c009
https://doi.org/10.1051/978-2-7598-2078-8.c009
Autor:
Corinne Millois, Loïc Tomas, Catherine Comino, Laurence Dumais, Sandrine Talano, Kevin Reverse, Céline Mathieu, Craig S. Harris, Nicolas Vanthuyne, Grégoire Mouis, Anne-Laurence Ghilini, Laurent F. Hennequin, Claire Bouix-Peter, Vincent Rodeschini, Ghizlane El-Bazbouz, Laurence Clary, Sandrine Chambon, Romain Pierre, Jean-François Fournier, Anne Brethon
Publikováno v:
Tetrahedron
Tetrahedron, Elsevier, 2018, 74 (37), pp.4805-4822. ⟨10.1016/j.tet.2018.07.029⟩
Tetrahedron, 2018, 74 (37), pp.4805-4822. ⟨10.1016/j.tet.2018.07.029⟩
Tetrahedron, Elsevier, 2018, 74 (37), pp.4805-4822. ⟨10.1016/j.tet.2018.07.029⟩
Tetrahedron, 2018, 74 (37), pp.4805-4822. ⟨10.1016/j.tet.2018.07.029⟩
International audience; During our search for topically-active Caspase-1 inhibitors, we identified a novel class of potent in-hibitors based on a 1,3,5-trisubstituted uracil motif equipped with an L-aspartate semi-aldehyde derived warhead. In the lit
Autor:
Catherine Soulet, Laurent F. Hennequin, Nicolas Fleury-Brégeot, Craig S. Harris, Blanche Gauthier, Gwenaëlle Duvert, Etienne Thoreau, Laurent Chantalat, Karine Grisendi, Jean-François Fournier, Jerome Aubert, Michèle Aurelly, Rémy Morgentin, Claire Bouix-Peter, Bénédicte Drean, Guillaume Lafitte, Yushma Bhurruth-Alcor, Florence Joly, Jonathan Pascau, Branislav Musicki, Yves Rival, David Piwnica, Karinne Bouquet, Marion Delorme, T. Isabet, Corinne Millois, Loïc Tomas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2985-2992
A series of squaramide-based hydroxamic acids were designed, synthesized and evaluated against human HDAC enzyme. Squaramides were found to be potent in the Hut78 cell line, but initially suffered from low solubility. Leads with improved solubility a
Autor:
Laurence Dumais, Gilles Ouvry, Laurent Chantalat, Angélique Feret, Sandrine Chambon, Thibaud Portal, Sandrine Talano, Gwenaëlle Duvert, Catherine Soulet, Jean-Marie Arlabosse, Samuel Tabet, Sebastien Daver, Jonathan Pascau, Nicolas Rodeville, Catherine Raffin, Claire Bouix-Peter, Etienne Thoreau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1736-1741
Retinoids have a dominant role in topical acne therapy and to date, only RARβ and RARγ dual agonists have reached the market. Given the tissue distribution of RAR isoforms, it was hypothesized that developing RARγ -selective agonists could yield a
Autor:
Didier M. Roche, Danielle Orfila, Ghizlane El-Bazbouz, Laurence Dumais, Laurent F. Hennequin, Céline Mathieu, Michèle Aurelly, Jerome Aubert, Claude Lardy, Etienne Thoreau, Anne-Pascale Luzy, Claire Bouix-Peter, Kenny Mebrouk, T. Isabet, Jean-François Fournier, Kevin Reverse, Catherine Comino, Corinne Millois, Anne-Laurence Ghilini, Jonathan Pascau, Sandrine Talano, Anne Brethon, Craig S. Harris, Romain Pierre, Sandrine Chambon, Laurence Clary, Olivier Christin, Laurent Chantalat, Vincent Rodeschini
Publikováno v:
Journal of Medicinal Chemistry. 61:4030-4051
The use of an interleukin β antibody is currently being investigated in the clinic for the treatment of acne, a dermatological disorder affecting 650M persons globally. Inhibiting the protease responsible for the cleavage of inactive pro-IL1β into
Publikováno v:
Journal of Medicinal Chemistry. 61:3231-3236
Phototoxicity occurs when UV irradiation causes otherwise benign compounds to become irritant, sensitizers, or even genotoxic. This toxicity is particularly a concern after topical application and in dermatological programs where skin irritation can