Výsledky vyhledávání - "Claire Baine"

Akademický článek

The single-dose Janssen Ad26.COV2.S COVID-19 vaccine elicited robust and persistent anti-spike IgG antibody responses in a 12-month Ugandan cohort

Autor: Jennifer Serwanga, Laban Kato, Gerald Kevin Oluka, Violet Ankunda, Jackson Sembera, Claire Baine, Isaac Kitabye, Angela Namuyanja, Solomon Opio, Joseph Ssebwana Katende, Peter Ejou, The COVID-19 Immunoprofiling Team, Pontiano Kaleebu

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionThe study investigation examined the immune response to the Janssen Ad26.COV2.S COVID-19 vaccine within a Ugandan cohort, specifically targeting antibodies directed against spike (S) and nucleocapsid (N) proteins. We aimed to examine the

Externí odkaz: https://doaj.org/article/1db485c38c5a405ea296012ef5315fec

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Akademický článek

Spike protein is a key target for stronger and more persistent T-cell responses—a study of mild and asymptomatic SARS-CoV-2 infection

Publikováno v: International Journal of Infectious Diseases, Vol 136, Iss , Pp 49-56 (2023)

Objectives: Understanding the immune response in very mild and asymptomatic COVID-19 is crucial for developing effective vaccines and immunotherapies, yet remains poorly characterized. This longitudinal study examined the evolution of interferon (IFN

Externí odkaz: https://doaj.org/article/cbaf82e9d50547daa18c5ec0a1588d8b

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Akademický článek

The subdued post-boost spike-directed secondary IgG antibody response in Ugandan recipients of the Pfizer-BioNTech BNT162b2 vaccine has implications for local vaccination policies

Autor: Violet Ankunda, Joseph Ssebwana Katende, Gerald Kevin Oluka, Jackson Sembera, Claire Baine, Geoffrey Odoch, Peter Ejou, Laban Kato, The COVID-19 Immunoprofiling Team, Pontiano Kaleebu, Jennifer Serwanga, Christine Hermilia Akoli, Angela Namuyanja, Solomon Opio, Arthur Watelo Kalyebi, Ivan Ssali, Ben Gombe, Susan Mugaba, Hellen Nantambi

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionThis study aimed to delineate longitudinal antibody responses to the Pfizer-BioNTech BNT162b2 COVID-19 vaccine within the Ugandan subset of the Sub-Saharan African (SSA) demographic, filling a significant gap in global datasets.MethodsWe

Externí odkaz: https://doaj.org/article/749743b1ec32400191b68e3c3266412d

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Akademický článek

Persistent and robust antibody responses to ChAdOx1-S Oxford-AstraZeneca (ChAdOx1-S, Covishield) SARS-CoV-2 vaccine observed in Ugandans across varied baseline immune profiles.

Autor: Jennifer Serwanga, Gerald Kevin Oluka, Claire Baine, Violet Ankunda, Jackson Sembera, Laban Kato, Joseph Ssebwana Katende, Geoffrey Odoch, Betty Oliver Auma, Ben Gombe, COVID-19 Immunoprofiling Team, Monica Musenero, Pontiano Kaleebu

Publikováno v: PLoS ONE, Vol 19, Iss 7, p e0303113 (2024)

Understanding SARS-CoV-2 vaccine-induced antibody responses in varied antigenic and serological prior exposures can guide optimal vaccination strategies for enhanced immunogenicity. We evaluated spike (S)-directed IgG, IgM, and IgA antibody optical d

Externí odkaz: https://doaj.org/article/97ffa7599c1441e4807481d7a29eb2bb

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Akademický článek

Sustained S-IgG and S-IgA antibodies to Moderna’s mRNA-1273 vaccine in a Sub-Saharan African cohort suggests need for booster timing reconsiderations

Autor: Jennifer Serwanga, Violet Ankunda, Joseph Ssebwana Katende, Claire Baine, Gerald Kevin Oluka, Geoffrey Odoch, Hellen Nantambi, Susan Mugaba, Angella Namuyanja, Ivan Ssali, Peter Ejou, Laban Kato, The COVID-19 Immunoprofiling Team, Monica Musenero, Pontiano Kaleebu, Jackson Sembera, Betty Oliver Auma, Solomon Opio, Ben Gombe

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionThis study sought to elucidate the long-term antibody responses to the Moderna mRNA-1273 COVID-19 vaccine within a Ugandan cohort, aiming to contribute to the sparse data on m-RNA vaccine immunogenicity in Sub-Saharan Africa.MethodsWe tra

Externí odkaz: https://doaj.org/article/4193f652b87f48fe898580c284e37647

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Akademický článek

An Optimised Indirect ELISA Protocol for Detection and Quantification of Anti-viral Antibodies in Human Plasma or Serum: A Case Study Using SARS-CoV-2

Autor: Claire Baine, Jackson Sembera, Gerald Oluka, Joseph Katende, Violet Ankunda, Jennifer Serwanga

Publikováno v: Bio-Protocol, Vol 13, Iss 24 (2023)

Advanced immunoassays are crucial in assessing antibody responses, serving immune surveillance goals, characterising immunological responses to evolving viral variants, and guiding subsequent vaccination initiatives. This protocol outlines an indirec

Externí odkaz: https://doaj.org/article/f3f64149b8b440a28ec478d541981278

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Akademický článek

Sustained spike-specific IgG antibodies following CoronaVac (Sinovac) vaccination in sub-Saharan Africa, but increased breakthrough infections in baseline spike-naive individuals

Autor: Jackson Sembera, Claire Baine, Violet Ankunda, Joseph Ssebwana Katende, Gerald Kevin Oluka, Christine Hermilia Akoli, Laban Kato, Geoffrey Odoch, Peter Ejou, Solomon Opio, Monica Musenero, The COVID-19 Immunoprofiling Team, Pontiano Kaleebu, Jennifer Serwanga

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionThis study investigated the antibody responses to the inactivated COVID-19 vaccine, CoronaVac (Sinovac Biotech) in the African population to provide valuable insights into long-term immunity and breakthrough infections against SARS-CoV-2

Externí odkaz: https://doaj.org/article/fd22ad6deacf4d7ba908cf15ff6472fc

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Akademický článek

Seroprevalence and durability of antibody responses to AstraZeneca vaccination in Ugandans with prior mild or asymptomatic COVID-19: implications for vaccine policy

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionThe duration and timing of immunity conferred by COVID-19 vaccination in sub-Saharan Africa are crucial for guiding pandemic policy interventions, but systematic data for this region is scarce. This study investigated the antibody respons

Externí odkaz: https://doaj.org/article/12ba7b1e3b934d3ea067f47b5d80e727

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Akademický článek

Pre-pandemic SARS-CoV-2-specific IFN-γ and antibody responses were low in Ugandan samples and significantly reduced in HIV-positive specimens

Autor: Hellen Nantambi, Jackson Sembera, Violet Ankunda, Ivan Ssali, Arthur Watelo Kalyebi, Gerald Kevin Oluka, Laban Kato, Bahemuka Ubaldo, Freddie Kibengo, Joseph Ssebwana Katende, Ben Gombe, Claire Baine, Geoffrey Odoch, Susan Mugaba, Obondo James Sande, The COVID-19 Immunoprofiling Team, Pontiano Kaleebu, Jennifer Serwanga

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionWe investigated whether prior SARS-CoV-2-specific IFN-γ and antibody responses in Ugandan COVID-19 pre-pandemic specimens aligned to this population's low disease severity.MethodsWe used nucleoprotein (N), spike (S), NTD, RBD, envelope,

Externí odkaz: https://doaj.org/article/546f6a4b64e04285a89374a02f81b4d1

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Akademický článek

Rapid, early, and potent Spike-directed IgG, IgM, and IgA distinguish asymptomatic from mildly symptomatic COVID-19 in Uganda, with IgG persisting for 28 months

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionUnderstanding how spike (S)-, nucleoprotein (N)-, and RBD-directed antibody responses evolved in mild and asymptomatic COVID-19 in Africa and their interactions with SARS-CoV-2 might inform development of targeted treatments and vaccines.

Externí odkaz: https://doaj.org/article/8d0ed8976a684d0e97e34dc7c9ba05d2

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