Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Claire A. Shepherd"'
Autor:
Filip Vujovic, Mary Simonian, William E. Hughes, Claire E. Shepherd, Neil Hunter, Ramin M. Farahani
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Mitochondrial activity directs neuronal differentiation dynamics during brain development. In this context, the long-established metabolic coupling of mitochondria and the eukaryotic host falls short of a satisfactory mechanistic explanation
Externí odkaz:
https://doaj.org/article/e614816f591446b3bb144eb2a89bf3bd
Autor:
Rachel H. Tan, Heather McCann, Claire E. Shepherd, Monica Pinkerton, Srestha Mazumder, Emma M. Devenney, Gabrielle L. Adler, Dominic B. Rowe, Jillian Kril, Glenda M. Halliday, Matthew C. Kiernan
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Background Despite the presence of significant cortical pTDP-43 inclusions of heterogeneous morphologies in patients diagnosed with amyotrophic lateral sclerosis (ALS), pathological subclassification is routinely performed in the minority of
Externí odkaz:
https://doaj.org/article/d388ba55658c42378209fd9d692b85ed
Autor:
Grant L. Iverson, Pouya Jamshidi, Amanda O. Fisher-Hubbard, Amy Deep-Soboslay, Thomas M. Hyde, Joel E. Kleinman, Joyce L. deJong, Claire E. Shepherd, Lili-Naz Hazrati, Rudolph J. Castellani
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionWe examined postmortem brain tissue from men, over the age of 50, for chronic traumatic encephalopathy neuropathologic change (CTE-NC). We hypothesized that (i) a small percentage would have CTE-NC, (ii) those who played American football
Externí odkaz:
https://doaj.org/article/857b1001775f471c9183059d1508598a
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1873 (2023)
Metazoan signalling pathways can be rewired to dampen or amplify the rate of events, such as those that occur in development and aging. Given that a linear network topology restricts the capacity to rewire signalling pathways, such scalability of the
Externí odkaz:
https://doaj.org/article/ba92bc202a4d44ce899279c37ce07555
Autor:
Giorgio Cerro, Srinandan Dasmahapatra, Henry A. Day-Hall, Billy Ford, Stefano Moretti, Claire H. Shepherd-Themistocleous
Publikováno v:
Journal of High Energy Physics, Vol 2022, Iss 2, Pp 1-30 (2022)
Abstract We present a new approach to jet definition alternative to clustering methods, such as the anti-kT scheme, that exploit kinematic data directly. Instead the new method uses kinematic information to represent the particles in a multidimension
Externí odkaz:
https://doaj.org/article/95dd40d66b7a42b59d6af1a3d525ada6
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, pathologically hallmarked by the loss of dopamine neurons in the substantia nigra (SN) and alpha-synuclein aggregation. Deep brain stimulation (DBS) of the subthalamic nucleus (S
Externí odkaz:
https://doaj.org/article/4155f2052f774fce9d04faf50ce778ae
Publikováno v:
Journal of High Energy Physics, Vol 2021, Iss 6, Pp 1-20 (2021)
Abstract We study displaced signatures of sneutrino pairs potentially emerging at the Large Hadron Collider (LHC) in a Next-to-Minimal Supersymmetric Standard Model supplemented with right-handed neutrinos triggering a Type-I seesaw mechanism. We sho
Externí odkaz:
https://doaj.org/article/c68e4e7ca03346b4ba30d333dc7e8f6c
Autor:
Sanka Amadoru, Vincent Doré, Catriona A. McLean, Fairlie Hinton, Claire E. Shepherd, Glenda M. Halliday, Cristian E. Leyton, Paul A. Yates, John R. Hodges, Colin L. Masters, Victor L. Villemagne, Christopher C. Rowe
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-8 (2020)
Abstract Background The Centiloid scale was developed to standardise the results of beta-amyloid (Aβ) PET. We aimed to determine the Centiloid unit (CL) thresholds for CERAD sparse and moderate-density neuritic plaques, Alzheimer’s disease neuropa
Externí odkaz:
https://doaj.org/article/cc27d92619bd4230adff490e4b06e8ab
Autor:
Tatiana Orme, Dena Hernandez, Owen A. Ross, Celia Kun-Rodrigues, Lee Darwent, Claire E. Shepherd, Laura Parkkinen, Olaf Ansorge, Lorraine Clark, Lawrence S. Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St. George-Hyslop, Elisabet Londos, Henrik Zetterberg, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, John Q. Trojanowski, Geidy E. Serrano, Thomas G. Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Pentti J. Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J. Cairns, John C. Morris, Stuart Pickering-Brown, David Mann, Glenda Halliday, David J. Stone, Dennis W. Dickson, John Hardy, Andrew Singleton, Rita Guerreiro, Jose Bras
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Abstract Dementia with Lewy bodies (DLB) is a clinically heterogeneous disorder with a substantial burden on healthcare. Despite this, the genetic basis of the disorder is not well defined and its boundaries with other neurodegenerative diseases are
Externí odkaz:
https://doaj.org/article/eb7da7eb422d4a428e7652ae48f842e3
Autor:
Claire E. Shepherd, Andrew J. Affleck, Anita Y. Bahar, Francine Carew‐Jones, Gillian Gregory, David H. Small, Glenda M. Halliday
Publikováno v:
Brain and Behavior, Vol 10, Iss 7, Pp n/a-n/a (2020)
Abstract Introduction One of the major neuropathological features of Alzheimer's disease (AD) is the accumulation of amyloid‐β (Aβ) protein in the brain. Evidence suggests that the low‐density lipoprotein receptor‐associated protein (RAP) bin
Externí odkaz:
https://doaj.org/article/e3970b84d9604b6990d20cf710451d4b