Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Claire, Vennin"'
Autor:
Rebeca Uceda-Castro, Jessy V. van Asperen, Claire Vennin, Jacqueline A. Sluijs, Emma J. van Bodegraven, Andreia S. Margarido, Pierre A. J. Robe, Jacco van Rheenen, Elly M. Hol
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Glioma is the most common form of malignant primary brain tumours in adults. Their highly invasive nature makes the disease incurable to date, emphasizing the importance of better understanding the mechanisms driving glioma invasion. Glial f
Externí odkaz:
https://doaj.org/article/b501743dc3ad44f6bf599962b165fe6f
Autor:
Monisha Samuel, Pamali Fonseka, Rahul Sanwlani, Lahiru Gangoda, Sing Ho Chee, Shivakumar Keerthikumar, Alex Spurling, Sai V. Chitti, Damien Zanker, Ching-Seng Ang, Ishara Atukorala, Taeyoung Kang, Sanjay Shahi, Akbar L. Marzan, Christina Nedeva, Claire Vennin, Morghan C. Lucas, Lesley Cheng, David Herrmann, Mohashin Pathan, David Chisanga, Sean C. Warren, Kening Zhao, Nidhi Abraham, Sushma Anand, Stephanie Boukouris, Christopher G. Adda, Lanzhou Jiang, Tanmay M. Shekhar, Nikola Baschuk, Christine J. Hawkins, Amelia J. Johnston, Jacqueline Monique Orian, Nicholas J. Hoogenraad, Ivan K. Poon, Andrew F. Hill, Markandeya Jois, Paul Timpson, Belinda S. Parker, Suresh Mathivanan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dietary extracellular vesicles (EVs) could potentially be absorbed by the intestinal tract of the host and exert multiple phenotypic changes. Here, the authors isolate and characterize EVs from raw and commercial bovine milk and show orally administe
Externí odkaz:
https://doaj.org/article/a210d2d7abd146b99318109f85a7d355
Autor:
Claire Vennin, Pauline Mélénec, Romain Rouet, Max Nobis, Aurélie S. Cazet, Kendelle J. Murphy, David Herrmann, Daniel A. Reed, Morghan C. Lucas, Sean C. Warren, Zehra Elgundi, Mark Pinese, Gabriella Kalna, Daniel Roden, Monisha Samuel, Anaiis Zaratzian, Shane T. Grey, Andrew Da Silva, Wilfred Leung, Australian Pancreatic Genome Initiative (APGI), Suresh Mathivanan, Yingxiao Wang, Anthony W. Braithwaite, Daniel Christ, Ales Benda, Ashleigh Parkin, Phoebe A. Phillips, John M. Whitelock, Anthony J. Gill, Owen J. Sansom, David R. Croucher, Benjamin L. Parker, Marina Pajic, Jennifer P. Morton, Thomas R. Cox, Paul Timpson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-22 (2019)
Subtypes of cancer associated fibroblasts can both promote and suppress tumorigenesis. Here, the authors investigate how p53 status in pancreatic cancer cells affects their interaction with cancer associated fibroblasts, and report perlecan as a medi
Externí odkaz:
https://doaj.org/article/9cbe7f002204495db0cd437d4360e24c
Autor:
Andreia V. Pinho, Mathias Van Bulck, Lorraine Chantrill, Mehreen Arshi, Tatyana Sklyarova, David Herrmann, Claire Vennin, David Gallego-Ortega, Amanda Mawson, Marc Giry-Laterriere, Astrid Magenau, Gunther Leuckx, Luc Baeyens, Anthony J. Gill, Phoebe Phillips, Paul Timpson, Andrew V. Biankin, Jianmin Wu, Ilse Rooman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
SLIT-ROBO alterations arise in pancreatic ductal adenocarcinoma (PDAC), but their role in the pancreas is unclear. Here, the authors use mouse models to show that loss of epithelial Robo2 activates the neighbouring stroma via TGF-β signalling; findi
Externí odkaz:
https://doaj.org/article/7bcf752c0ac345e8b916a29cc45a9a4f
Autor:
Murugan Kalimutho, Debottam Sinha, Jessie Jeffery, Katia Nones, Sriganesh Srihari, Winnie C Fernando, Pascal HG Duijf, Claire Vennin, Prahlad Raninga, Devathri Nanayakkara, Deepak Mittal, Jodi M Saunus, Sunil R Lakhani, J Alejandro López, Kevin J Spring, Paul Timpson, Brian Gabrielli, Nicola Waddell, Kum Kum Khanna
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-22 (2018)
Abstract The centrosomal protein, CEP55, is a key regulator of cytokinesis, and its overexpression is linked to genomic instability, a hallmark of cancer. However, the mechanism by which it mediates genomic instability remains elusive. Here, we showe
Externí odkaz:
https://doaj.org/article/81a0772c1ea5410bbe8b8145afcfbc3d
Autor:
James R.W. Conway, Sean C. Warren, David Herrmann, Kendelle J. Murphy, Aurélie S. Cazet, Claire Vennin, Robert F. Shearer, Monica J. Killen, Astrid Magenau, Pauline Mélénec, Mark Pinese, Max Nobis, Anaiis Zaratzian, Alice Boulghourjian, Andrew M. Da Silva, Gonzalo del Monte-Nieto, Arne S.A. Adam, Richard P. Harvey, Jody J. Haigh, Yingxiao Wang, David R. Croucher, Owen J. Sansom, Marina Pajic, C. Elizabeth Caldon, Jennifer P. Morton, Paul Timpson
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3312-3326 (2018)
Summary: Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to therapeutic inhibition of the PI3K pathway within the hypoxic microenvironment of pancre
Externí odkaz:
https://doaj.org/article/1dd7417190fc4a1586f84ed7e4b76935
Autor:
Hamish Campbell, Nicholas Fleming, Imogen Roth, Sunali Mehta, Anna Wiles, Gail Williams, Claire Vennin, Nikola Arsic, Ashleigh Parkin, Marina Pajic, Fran Munro, Les McNoe, Michael Black, John McCall, Tania L. Slatter, Paul Timpson, Roger Reddel, Pierre Roux, Cristin Print, Margaret A. Baird, Antony W. Braithwaite
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Aberrant expression of the Δ133p53 isoform is linked to many cancers. Here, the authors utilise a model of the Δ133p53 isoform that is prone to tumours and inflammation, showing that Δ133p53 promotes tumour cell invasion by activation of the JAK-S
Externí odkaz:
https://doaj.org/article/4c1f6ec1d79b419c8e9e3bfbf63ac5e5
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts
Autor:
Max Nobis, David Herrmann, Sean C. Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C. Lucas, Nadine Reischmann, Claire Vennin, James R.W. Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M. Law, David Gallego-Ortega, Christopher J. Ormandy, Stacey N. Walters, Shane T. Grey, Jacqueline Bailey, Tatyana Chtanova, Julian M.W. Quinn, Paul A. Baldock, Peter I. Croucher, Juliane P. Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C. Hardeman, Peter W. Gunning, Gonzalo del Monte-Nieto, Richard P. Harvey, Michael S. Samuel, Marina Pajic, Ewan J. McGhee, Anna-Karin E. Johnsson, Owen J. Sansom, Heidi C.E. Welch, Jennifer P. Morton, Douglas Strathdee, Kurt I. Anderson, Paul Timpson
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 274-288 (2017)
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development
Externí odkaz:
https://doaj.org/article/c83a8ae4b29e4df59cdaacb8bc5a5802
Autor:
Jacco van Rheenen, Sabine C. Linn, Alexander van Oudenaarden, Hendrika M. Oosterkamp, Marleen Kok, Lodewyk F.A. Wessels, Emile E. Voest, Jelle Wesseling, Hugo M. Horlings, Emiel J. Rutgers, Sandra D. Bakker, Monique E.M.M. Bos, Johanneke E.A. Portielje, Alex L.T. Imholz, Harm van Tinteren, Sander Canisius, A. Elise van Leeuwen-Stok, Ingrid A.M. Mandjes, Ester H. Lips, Iris Nederlof, Kerstin Hahn, Erik van Werkhoven, Mark Opdam, Daphne van der Velden, Marlous Hoogstraat, Claire Vennin, Annelot G.J. van Rossum, Danielle Seinstra, Lennart Kester
Supplementary Data from Differential Survival and Therapy Benefit of Patients with Breast Cancer Are Characterized by Distinct Epithelial and Immune Cell Microenvironments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda851a306f2549e78bf661bc1193ab4
https://doi.org/10.1158/1078-0432.22482825
https://doi.org/10.1158/1078-0432.22482825
Autor:
Jacco van Rheenen, Sabine C. Linn, Alexander van Oudenaarden, Hendrika M. Oosterkamp, Marleen Kok, Lodewyk F.A. Wessels, Emile E. Voest, Jelle Wesseling, Hugo M. Horlings, Emiel J. Rutgers, Sandra D. Bakker, Monique E.M.M. Bos, Johanneke E.A. Portielje, Alex L.T. Imholz, Harm van Tinteren, Sander Canisius, A. Elise van Leeuwen-Stok, Ingrid A.M. Mandjes, Ester H. Lips, Iris Nederlof, Kerstin Hahn, Erik van Werkhoven, Mark Opdam, Daphne van der Velden, Marlous Hoogstraat, Claire Vennin, Annelot G.J. van Rossum, Danielle Seinstra, Lennart Kester
Purpose:Extensive work in preclinical models has shown that microenvironmental cells influence many aspects of cancer cell behavior, including metastatic potential and their sensitivity to therapeutics. In the human setting, this behavior is mainly c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da2ff38eb6c3e54d9efc292232c0a49
https://doi.org/10.1158/1078-0432.c.6530997.v1
https://doi.org/10.1158/1078-0432.c.6530997.v1