Calreticulin levels determine onset of early muscle denervation by fast motoneurons of ALS model mice

Autor: Nathalie Bernard-Marissal, Claire Sunyach, Thomas Marissal, Cédric Raoul, Brigitte Pettmann

Publikováno v: Neurobiology of Disease, Vol 73, Iss , Pp 130-136 (2015)

Although the precise signaling mechanisms underlying the vulnerability of some sub-populations of motoneurons in ALS remain unclear, critical factors such as metallo-proteinase 9 expression, neuronal activity and endoplasmic reticulum stress have bee

Externí odkaz: https://doaj.org/article/e821095640d1445893de3fa7624ddf35

Assessment of a Screening Questionnaire to Identify Exposure to Lead in Pregnant Women

Autor: Jeanne Perrin, Christel Pissier, Claire Sunyach, Florence Bretelle, Marine Freuchet, Julien Mancini, Blandine Courbiere, Eléna Coiplet, Hélène Heckenroth, Naima Hamdaoui

Publikováno v: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, 2020, 17 (24), pp.9220. ⟨10.3390/ijerph17249220⟩
Volume 17
Issue 24
International Journal of Environmental Research and Public Health, MDPI, 2020, 17 (24), pp.9220. ⟨10.3390/ijerph17249220⟩
International Journal of Environmental Research and Public Health, Vol 17, Iss 9220, p 9220 (2020)

Lead readily crosses the placenta and displays adverse effects on birth outcomes and neurodevelopment. Systematic identification of the risk of exposure during pregnancy is essential but rarely performed, probably due to hospital staff&rsquo
s w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd77b5a42d79aaa67ac8428cab6808a4
https://hal.science/hal-03146067/document

Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).

Autor: Richard J Mead, Ellen J Bennett, Aneurin J Kennerley, Paul Sharp, Claire Sunyach, Paul Kasher, Jason Berwick, Brigitte Pettmann, Guiseppe Battaglia, Mimoun Azzouz, Andrew Grierson, Pamela J Shaw

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23244 (2011)

The human SOD1(G93A) transgenic mouse has been used extensively since its development in 1994 as a model for amyotrophic lateral sclerosis (ALS). In that time, a great many insights into the toxicity of mutant SOD1 have been gained using this and oth

Externí odkaz: https://doaj.org/article/0a8e58065d064ae8ae3e91567ca6ba0c

A Rare Motor Neuron Deleterious Missense Mutation in theDPYSL3(CRMP4) Gene is Associated with ALS

Autor: Patrick Vourc'h, Gérard Besson, Charlotte Veyrat-Durebex, Olivier Augereau, Philippe Corcia, William Camu, Peter M. Andersen, Paul H. Gordon, Christian R. Andres, Catherine Antar, François Salachas, Nathalie Bernard-Marissal, Claire Sunyach, Vincent Meininger, Joelle Khederchah, Kevin Mouzat, Brigitte Pettmann, Yves Olivier Guettard, Hélène Blasco

Publikováno v: Human Mutation. 34:953-960

The dihydropyrimidinase-like 3 (DPYSL3) or Collapsin Response Mediator Protein 4a (CRMP4a) expression is modified in neurodegeneration and is involved in several ALS-associated pathways including axonal transport, glutamate excitotoxicity, and oxidat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0016efab20847bd8e2485136d8a5c8f
https://doi.org/10.1002/humu.22329

Reduced Calreticulin Levels Link Endoplasmic Reticulum Stress and Fas-Triggered Cell Death in Motoneurons Vulnerable to ALS

Autor: Nathalie Bernard-Marissal, Christophe Pellegrino, Christopher E. Henderson, Brigitte Pettmann, Keith Dudley, Anice Moumen, Cédric Raoul, Claire Sunyach

Publikováno v: Journal of Neuroscience; Vol 32
Journal of Neuroscience

Cellular responses to protein misfolding are thought to play key roles in triggering neurodegeneration. In the mutant superoxide dismutase (mSOD1) model of amyotrophic lateral sclerosis (ALS), subsets of motoneurons are selectively vulnerable to dege

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108e99443a35367a4b5f8edf6b0eea04