Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Claire, Hutchings"'
Autor:
Wojciech Barczak, Simon M. Carr, Geng Liu, Shonagh Munro, Annalisa Nicastri, Lian Ni Lee, Claire Hutchings, Nicola Ternette, Paul Klenerman, Alexander Kanapin, Anastasia Samsonova, Nicholas B. La Thangue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Long noncoding RNA molecules are RNA transcripts long thought to remain untranslated. In this study, the authors demonstrate that certain lncRNA can be translated into peptides that are immunogenic to CD8+ T cells and promote anti-tumour responses wh
Externí odkaz:
https://doaj.org/article/23d754b5fcb74be2b6886c3854660ad7
Autor:
Geng Liu, Wojciech Barczak, Lian Ni Lee, Amit Shrestha, Nicholas M. Provine, Gulsah Albayrak, Hong Zhu, Claire Hutchings, Paul Klenerman, Nicholas B. La Thangue
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
The clinical HDAC inhibitor zabadinostat increases MHC class I and II expression in dendritic cells, activates T and B cells, and enhances adaptive immune responses to COVID-19 spike protein in mice.
Externí odkaz:
https://doaj.org/article/677c416326a64b9dac386ff4677a2afa
Autor:
Claire Louse Gordon, Lian Ni Lee, Leo Swadling, Claire Hutchings, Madeleine Zinser, Andrew John Highton, Stefania Capone, Antonella Folgori, Eleanor Barnes, Paul Klenerman
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 768-782 (2018)
Summary: The induction and maintenance of T cell memory is critical to the success of vaccines. A recently described subset of memory CD8+ T cells defined by intermediate expression of the chemokine receptor CX3CR1 was shown to have self-renewal, pro
Externí odkaz:
https://doaj.org/article/21dd4267120b448e8614fa543e1f01fe
Autor:
Senthil K. Chinnakannan, Tamsin N. Cargill, Timothy A. Donnison, M. Azim Ansari, Sarah Sebastian, Lian Ni Lee, Claire Hutchings, Paul Klenerman, Mala K. Maini, Tom Evans, Eleanor Barnes
Publikováno v:
Vaccines, Vol 8, Iss 2, p 184 (2020)
Chronic hepatitis B virus (HBV) infection affects 257 million people globally. Current therapies suppress HBV but viral rebound occurs on cessation of therapy; novel therapeutic strategies are urgently required. To develop a therapeutic HBV vaccine t
Externí odkaz:
https://doaj.org/article/41c02f079e064ed5a43d58875bc1e6f9
Autor:
Lian N Lee, Beatrice Bolinger, Zoltan Banki, Catherine de Lara, Andrew J Highton, Julia M Colston, Claire Hutchings, Paul Klenerman
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006782 (2017)
The efficacies of many new T cell vaccines rely on generating large populations of long-lived pathogen-specific effector memory CD8 T cells. However, it is now increasingly recognized that prior infection history impacts on the host immune response.
Externí odkaz:
https://doaj.org/article/626b9d0344c24ca4baf49288d6449eb8
Autor:
Timothy Donnison, Joey McGregor, Senthil Chinnakannan, Claire Hutchings, Rob J. Center, Pantelis Poumbourios, Paul Klenerman, Heidi E. Drummer, Eleanor Barnes
Publikováno v:
Hepatology (Baltimore, Md.). 76(4)
A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organization elimination targets. Neutralizing antibodies (nAbs) and CD4We show that vaccinating with ChAd-Gt1-6 and E2Δ123These data are an impor
Autor:
Eleanor Barnes, Claire Hutchings, Timothy Donnison, Senthil Chinnakannan, A von Delft, Leo Swadling, Anthony Brown, Tomáš Hanke
Publikováno v:
Vaccine. 38:5036-5048
Background: Viral genetic variability presents a major challenge to the development of a prophylactic hepatitis C virus (HCV) vaccine. A promising HCV vaccine using chimpanzee adenoviral vectors (ChAd) encoding a genotype (gt) 1b non-structural prote
Autor:
Amit Kapoor, Dung Nguyen, Senthil Chinnakannan, Hannah Sharpe, Isabelle Dietrich, Michael A. Jarvis, Claire Hutchings, Carly M. Bliss, Kathrin Heim, Eleanor Barnes, Wenqin Li, Peter Simmonds, Paul Klenerman, Erwan Atcheson
Publikováno v:
Hepatology (Baltimore, Md.)
Background and Aims:The lack of immunocompetent small animal models for hepatitis C virus (HCV) has greatly hindered the development of effective vaccines. Using rodent hepacivirus (RHV), a homolog of HCV that shares many characteristics of HCV infec
Autor:
Esha Sarkar, Antonio Gonzalez-Lopez, Ilse Dieussaert, L Silva-Reyes, Marta Picciolato, Matthew D. Snape, Michel Janssens, Catherine de Lara, Philippe Moris, Laurence Fissette, Claire Hutchings, P Cicconi, Paul Klenerman, Amanda J. Leach, Claire Jones
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background Respiratory syncytial virus (RSV) disease is a major cause of infant morbidity and mortality. This Phase I, randomized, observer-blind, placebo- and active-controlled study evaluated an investigational vaccine against RSV (ChAd155-RSV) usi