Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Claire, Emson"'
Autor:
Elizabeth R. Volkmann, Christopher P. Denton, Martin Kolb, Marlies S. Wijsenbeek-Lourens, Claire Emson, Krischan Hudson, Anthony J. Amatucci, Oliver Distler, Yannick Allanore, Dinesh Khanna
Publikováno v:
European Respiratory Review, Vol 33, Iss 172 (2024)
Lysophosphatidic acid (LPA)-mediated activation of LPA receptor 1 (LPAR1) contributes to the pathophysiology of fibrotic diseases such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc). These diseases are associated with high morbid
Externí odkaz:
https://doaj.org/article/7dad0459aeb649318b278eb58358677c
Autor:
Claire Emson, Sarah Diver, Latifa Chachi, Ayman Megally, Cherrie Small, John Downie, Jane R. Parnes, Karin Bowen, Gene Colice, Chris E. Brightling
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway. Tezepelumab is a human m
Externí odkaz:
https://doaj.org/article/c2a1c95e81a5415ba02a0c5caa7789fd
Autor:
Carlo Calissano, Rajendra N. Damle, Sonia Marsilio, Xiao-Jie Yan, Sophia Yancopoulos, Gregory Hayes, Claire Emson, Elizabeth J. Murphy, Marc K. Hellerstein, Cristina Sison, Matthew S. Kaufman, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Ivana Ivanovic, Igor M. Dozmorov, Sergio Roa, Matthew D. Scharff, Wentian Li, Nicholas Chiorazzi
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c3739f0c9598420c8799dd44901b0253
Autor:
Sarah, Diver, Sriram, Sridhar, Latifa C, Khalfaoui, Richard J, Russell, Claire, Emson, Janet M, Griffiths, Melissa, de Los Reyes, Da, Yin, Gene, Colice, Christopher E, Brightling
Publikováno v:
Journal of Allergy and Clinical Immunology. 150:830-840
Understanding how asthma biomarkers relate to gene expression signatures could help identify drivers of pathogenesis.This post hoc exploratory analysis of the phase II tralokinumab trial MESOS (ClinicalTrials.gov identifier NCT02449473) aimed to prof
Autor:
Hsiao-Yen Ma, Qingling Li, Weng Ruh Wong, Elsa-Noah N’Diaye, Patrick Caplazi, Hannah Bender, Zhiyu Huang, Alexander Arlantico, Surinder Jeet, Aaron Wong, Claire Emson, Hans Brightbill, Lucinda Tam, Robert Newman, Merone Roose-Girma, Wendy Sandoval, Ning Ding
Publikováno v:
Science Advances. 9
Idiopathic pulmonary fibrosis is a progressive fibrotic disease characterized by excessive deposition of (myo)fibroblast produced collagen fibrils in alveolar areas of the lung. Lysyl oxidases (LOXs) have been proposed to be the central enzymes that
Autor:
Leslie Renee Cockerham, Steven A. Yukl, Kara Harvill, Ma Somsouk, Sunil K. Joshi, Elizabeth Sinclair, Teri Liegler, Rebecca Hoh, Sophie Lyons, Peter W. Hunt, Adam Rupert, Irini Sereti, David R. Morcock, Ajantha Rhodes, Claire Emson, Marc K. Hellerstein, Jacob D. Estes, Sharon Lewin, Steven G. Deeks, Hiroyu Hatano
Publikováno v:
Pathogens and Immunity, Vol 2, Iss 3, Pp 310-334 (2017)
Background: In HIV infection, lymphoid tissue is disrupted by fibrosis. Angiotensin converting enzyme inhibitors have anti-fibrotic properties. We completed a pilot study to assess whether the addition of lisinopril to antiretroviral therapy (ART) re
Externí odkaz:
https://doaj.org/article/33ba8fcfdd47470c8750883f7586966d
Autor:
Claire Emson, Sally E. Wenzel, Jane R. Parnes, James Johnston, Sarah Diver, Christopher E. Brightling, Latifa Khalfaoui, Ayman Megally, Nestor Molfino, Michael E. Wechsler, Gene L. Colice, Andrew Menzies-Gow
Publikováno v:
The Lancet Respiratory Medicine. 9:1299-1312
Summary Background Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine. In phase 2b and 3 studies, tezepelumab significantly reduced exacerbations versus plac
Autor:
Arianne van Koppen, Lars Verschuren, Anita M. van den Hoek, Joanne Verheij, Martine C. Morrison, Kelvin Li, Hiroshi Nagabukuro, Adalberto Costessi, Martien P.M. Caspers, Tim J. van den Broek, John Sagartz, Cornelis Kluft, Carine Beysen, Claire Emson, Alain J. van Gool, Roel Goldschmeding, Reinout Stoop, Ivana Bobeldijk-Pastorova, Scott M. Turner, Guido Hanauer, Roeland Hanemaaijer
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 1, Pp 83-98.e10 (2018)
The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynam
Externí odkaz:
https://doaj.org/article/592b66b824aa47b5807c7f2ccfe9465f
Autor:
Jennifer Louten,, Jeanine D. Mattson, Maria-Christina Malinao, Ying Li, Claire Emson, Felix Vega, Robert L. Wardle, Michael R. Van Scott, Robert B. Fick, Terrill K. McClanahan, Rene de Waal Malefyt, Maribel Beaumont
Publikováno v:
Biomarker Insights, Vol 2012, Iss 7, Pp 87-104 (2012)
Externí odkaz:
https://doaj.org/article/fd3fb9673f874c7d8dab8df2d3535926
Autor:
James Kreindler, Maria Jison, Martin Desrosiers, Claire Emson, Viktoria Werkström, David Cohen, Claire Hopkins, Ubaldo J. Martin, Vivian H. Shih, Joseph K. Han, Sofia Necander, Philippe Gevaert, Peter Barker, Claus Bachert, Enrico Heffler, Jody R. Tversky
Publikováno v:
The Journal of allergy and clinical immunology. 149(4)
Background Eosinophilic inflammation has been implicated in the pathogenesis, severity, and treatment responsiveness of chronic rhinosinusitis with nasal polyps (CRSwNP). Objective We sought to assess the efficacy and safety of benralizumab-mediated