Heightened metabolic responses in NK cells from patients with neuroblastoma suggests increased potential for immunotherapy

Autor: Karen Slattery, Megan Breheny, Elena Woods, Sinead Keating, Kiva Brennan, Caroline Rooney, Sindhu Augustine, Aishling Ryan, Cormac Owens, Clair M. Gardiner

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

High risk neuroblastoma is responsible for 15% of deaths in pediatric cancer patients. The introduction of anti-GD2 immunotherapy has significantly improved outcomes but there is still only approximately a 50% 5 year event-free-survival for these chi

Externí odkaz: https://doaj.org/article/6476f9ae284540058a098557b7658454

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Autor: Róisín M. Loftus, Nadine Assmann, Nidhi Kedia-Mehta, Katie L. O’Brien, Arianne Garcia, Conor Gillespie, Jens L. Hukelmann, Peter J. Oefner, Angus I. Lamond, Clair M. Gardiner, Katja Dettmer, Doreen A. Cantrell, Linda V. Sinclair, David K. Finlay

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expressi

Externí odkaz: https://doaj.org/article/428103db6a8c40348a0ae092d9d2a982

Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections

Autor: Hesham M. Shehata, Andrew J. Murphy, Man kit Sam Lee, Clair M. Gardiner, Suzanne M. Crowe, Shomyseh Sanjabi, David K. Finlay, Clovis Steve Palmer

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming throug

Externí odkaz: https://doaj.org/article/422cda86895e40e39ae714dcace1ba39

Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination

Autor: Clair M. Gardiner, Matthias Hoffmann, Vanessa Zaiatz-Bittencourt, Lucy Dorrell, Ventzi Vassilev, Bethany Turner, Ciaran Bannan, Stefania Capone, Shokouh Makvandi-Nejad, Colm Bergin, Tomáš Hanke, Elena Woods, David K. Finlay, Antonella Folgori, Anthony Brown, Eleanor Barnes

Publikováno v: npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
NPJ Vaccines

Effective vaccines for human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) remain a significant challenge for these infectious diseases. Given that the innate immune response is key to controlling the scale and nature of developing ada

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44466053ffaf3273091bb196157bff7
https://doi.org/10.1038/s41541-021-00381-w

TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer

Autor: David K. Finlay, Vanessa Zaiatz-Bittencourt, John Kennedy, Caitriona Goggin, Sam Marks, Colm MacEochagain, Clair M. Gardiner, Sonya Chew, Elena Woods, Karen Slattery, Michael Conroy, Sophie Lucas

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol. 9, no. 2, p. e002044 (2021)

BackgroundNatural killer (NK) cells provide important immune protection from cancer and are a key requirement for particular immunotherapies. There is accumulating evidence that NK cells become dysfunctional during cancer. Overcoming NK cell exhausti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27684137ce60d121136199ac0d95dd32
https://jitc.bmj.com/content/9/2/e002044.full