Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Clair M Gardiner"'
Autor:
Michael Conroy, John Kennedy, Karen Slattery, Elena Woods, Vanessa Zaiatz-Bittencourt, Sam Marks, Sonya Chew, Caitriona Goggin, Colm MacEochagain, Sophie Lucas, David K Finlay, Clair M Gardiner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Background Natural killer (NK) cells provide important immune protection from cancer and are a key requirement for particular immunotherapies. There is accumulating evidence that NK cells become dysfunctional during cancer. Overcoming NK cell exhaust
Externí odkaz:
https://doaj.org/article/b8a8d841ff7e409c8d04b1a423e2c8fe
Autor:
Jessica F Walls, Jeff J Subleski, Erika M Palmieri, Marieli Gonzalez-Cotto, Clair M Gardiner, Daniel W McVicar, David K Finlay
Publikováno v:
eLife, Vol 9 (2020)
Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The glycolytic enzyme Pyruvate Kin
Externí odkaz:
https://doaj.org/article/1481e7d755214c67a942f1f77128d836
Autor:
Christopher D Cluxton, Cathy Spillane, Sharon A O'Toole, Orla Sheils, Clair M Gardiner, John J O'Leary
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0211538 (2019)
Tumour cell immune evasion is a principal hallmark of successful metastasis. Tumour cells in the vasculature adopt a platelet cloak that efficiently suppresses the innate immune system by directly inhibiting Natural Killer (NK) cells, which normally
Externí odkaz:
https://doaj.org/article/9e932b8f5694416b8900424a4216c327
Autor:
Clair M Gardiner
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Hepatitis C virus (HCV) infects over 170 million people in the world. While a minority of individuals are able to naturally clear this hepatotropic virus using their immune system, most people go on to develop a lifetime chronic infection that can re
Externí odkaz:
https://doaj.org/article/7aa1977da7fb47199d6f794ecbfa4455
Autor:
Ciara Keane, Daire O'Shea, Thomas Reiberger, Markus Peck-Radosavljevic, Gillian Farrell, Colm Bergin, Clair M Gardiner
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66831 (2013)
Pegylated-IFN and ribavirin remains the current treatment for chronic HCV infection in patients co-infected with HIV-1, but this regimen has low efficacy rates, particularly for HCV genotype 1/4 infection, has severe side effects and is extremely cos
Externí odkaz:
https://doaj.org/article/c7928eae88da4a978f5c14564e462c84
Autor:
Karen Slattery, Megan Breheny, Elena Woods, Sinead Keating, Kiva Brennan, Caroline Rooney, Sindhu Augustine, Aishling Ryan, Cormac Owens, Clair M. Gardiner
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
High risk neuroblastoma is responsible for 15% of deaths in pediatric cancer patients. The introduction of anti-GD2 immunotherapy has significantly improved outcomes but there is still only approximately a 50% 5 year event-free-survival for these chi
Externí odkaz:
https://doaj.org/article/6476f9ae284540058a098557b7658454
Autor:
Clair M. Gardiner, Matthias Hoffmann, Vanessa Zaiatz-Bittencourt, Lucy Dorrell, Ventzi Vassilev, Bethany Turner, Ciaran Bannan, Stefania Capone, Shokouh Makvandi-Nejad, Colm Bergin, Tomáš Hanke, Elena Woods, David K. Finlay, Antonella Folgori, Anthony Brown, Eleanor Barnes
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
NPJ Vaccines
NPJ Vaccines
Effective vaccines for human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) remain a significant challenge for these infectious diseases. Given that the innate immune response is key to controlling the scale and nature of developing ada
Autor:
Clair M. Gardiner
Publikováno v:
Nature Immunology. 20:1561-1563
Manipulating the mitochondrial morphology of exhausted tumor-derived NK cells restores their metabolic fitness and function.
Autor:
Clair M. Gardiner
Publikováno v:
Journal of Leukocyte Biology. 105:1235-1242
Natural Killer (NK) cells are important antiviral and anticancer effector cells. They have excellent potential for immunotherapy although impaired functions during cancer limit their effectiveness. The discovery that cellular metabolism can impact on
Autor:
David K. Finlay, Vanessa Zaiatz-Bittencourt, John Kennedy, Caitriona Goggin, Sam Marks, Colm MacEochagain, Clair M. Gardiner, Sonya Chew, Elena Woods, Karen Slattery, Michael Conroy, Sophie Lucas
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol. 9, no. 2, p. e002044 (2021)
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol. 9, no. 2, p. e002044 (2021)
BackgroundNatural killer (NK) cells provide important immune protection from cancer and are a key requirement for particular immunotherapies. There is accumulating evidence that NK cells become dysfunctional during cancer. Overcoming NK cell exhausti