Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Clair Gallagher"'
Autor:
Alex J Eustace, Neil T Conlon, Martina S J McDermott, Brigid C Browne, Patrick O’Leary, Frankie A Holmes, Virginia Espina, Lance A Liotta, Joyce O’Shaughnessy, Clair Gallagher, Lorraine O’Driscoll, Sweta Rani, Stephen F Madden, Neil A O’Brien, Charles Ginther, Dennis Slamon, Naomi Walsh, William M Gallagher, Radoslaw Zagozdzon, William R Watson, Norma O’Donovan, John Crown
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Lapatinib has clinical efficacy in the treatment of trastuzumab-refractory HER2-positive breast cancer. However, a significant proportion of patients develop progressive disease due to acquired resistance to the drug. Induction of
Externí odkaz:
https://doaj.org/article/5de7181f330d45b98eeaa2bf7e64c819
Autor:
Noelia Sanchez, Mark Gallagher, Nga Lao, Clair Gallagher, Colin Clarke, Padraig Doolan, Sinead Aherne, Alfonso Blanco, Paula Meleady, Martin Clynes, Niall Barron
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65671 (2013)
MiR-7 acts as a tumour suppressor in many cancers and abrogates proliferation of CHO cells in culture. In this study we demonstrate that miR-7 targets key regulators of the G1 to S phase transition, including Skp2 and Psme3, to promote increased leve
Externí odkaz:
https://doaj.org/article/3c7d73595041443e97e7b24bd5130b88
Autor:
Ioanna Tzani, Marina Castro Rivadeneyra, Lin Zhang, Colin Clarke, Niall Barron, Ricardo Valdés-Bango Curell, Clair Gallagher, Krishna Motheramgari
Publikováno v:
Biotechnology and Bioengineering. 117:3224-3231
Our ability to study Chinese hamster ovary (CHO) cell biology has been revolutionised over the last decade following the development of next generation sequencing technology and publication of reference DNA sequences for CHO cells and the Chinese ham
Autor:
Mark G. Hamilton, John J. Evans, Jennifer Strahle, Michael Karsy, Douglas L. Brockmeyer, John Honeycutt, Garnette R. Sutherland, Eric C. Leuthardt, John R. W. Kestle, Yves Starreveld, Jeffrey R. Leonard, S. Hassan Akbari, David D. Limbrick, Walter Hader, Samuel H. Cheshier, Robert J. Bollo, Randy L. Jensen, Richard A Roberts, Clair Gallagher, Michael R. Chicoine, Ann-Christine Duhaime, David Donahue, Matthew D. Smyth, Daniel R. Hansen, Jay Riva-Cambrin
Publikováno v:
Journal of Neuro-Oncology. 143:271-280
The use of intraoperative MRI (iMRI) during treatment of gliomas may increase extent of resection (EOR), decrease need for early reoperation, and increase progression-free and overall survival, but has not been fully validated, particularly in the pe
Autor:
Michael Henry, Paula Meleady, Niall Barron, Clair Gallagher, Martin Clynes, Laura Bryan, Christopher C. Frye, Matthew D. Osborne, Ronan M. Kelly
Publikováno v:
Biotechnology Letters
Objectives We used miRNA and proteomic profiling to understand intracellular pathways that contribute to high and low specific productivity (Qp) phenotypes in CHO clonally derived cell lines (CDCLs) from the same cell line generation project. Results
Autor:
Neil T Conlon, Patrick O’Leary, Virginia Espina, William Watson, John Crown, Frankie A. Holmes, Sweta Rani, William M. Gallagher, Lance A. Liotta, Radoslaw Zagozdzon, Norma O'Donovan, Naomi Walsh, Alex J Eustace, Stephen F. Madden, Charles Ginther, Brigid C. Browne, Martina McDermott, Joyce O'Shaughnessy, Dennis J. Slamon, Neil A. O'Brien, Lorraine O'Driscoll, Clair Gallagher
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
BMC cancer, vol 18, iss 1
BMC Cancer
BMC cancer, vol 18, iss 1
BMC Cancer
Background Lapatinib has clinical efficacy in the treatment of trastuzumab-refractory HER2-positive breast cancer. However, a significant proportion of patients develop progressive disease due to acquired resistance to the drug. Induction of apoptoti
Autor:
Michael Henry, Paula Meleady, Martin Clynes, Christopher C. Frye, Ciaran P. Brady, Niall Barron, Clair Gallagher, Ronan M. Kelly, Matthew D. Osborne
Publikováno v:
Journal of Biotechnology. 281:21-30
Product degradation, such as clipping, is a common quality issue in the production of Fc-fusion proteins from Chinese hamster ovary (CHO) cells. Degradation of proteins is mainly due to the action of either intracellular or extracellular host cell pr
Autor:
Colin Clarke, Niall Barron, Lin Zhang, Ioanna Tzani, Ricardo Valdés-Bango Curell, Clair Gallagher, Marina Castro Rivadeneyra, Krishna Motheramgari
Our ability to study Chinese hamster ovary (CHO) cell biology has been revolutionised over the last decade with the development of next generation sequencing and the publication of reference DNA sequences for CHO cells and the Chinese hamster. RNA se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba0cf48a8e360404eaec67a6841d171
https://doi.org/10.1101/863241
https://doi.org/10.1101/863241
Autor:
Niall Barron, Jonathan Bones, Paul S. Kelly, Ryan Hagan, Craig Monger, Justine Meiller, Patrick Floris, Krishna Motheramgari, Martin Clynes, Lin Zhang, Colin Clarke, Alan Costello, Clair Gallagher, Ioanna Tzani
RNA sequencing (RNASeq) has been widely used to associate alterations in Chinese hamster ovary (CHO) cell gene expression with bioprocess phenotypes, however alternative mRNA splicing, has thus far, received little attention. In this study, we utilis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcdb8e9e417bbf37b42b3c273917440
https://doi.org/10.1101/863175
https://doi.org/10.1101/863175
Autor:
Mark G. Hamilton, Douglas L. Brockmeyer, Richard A Roberts, Walter Hader, Samuel H. Cheshier, Jennifer Strahle, Michael Karsy, Robert J. Bollo, Ann-Christine Duhaime, Matthew D. Smyth, David J. Donahue, David D. Limbrick, Yves Starreveld, Eric C. Leuthardt, John Honeycutt, Daniel R. Hansen, John J. Evans, Jeffrey R. Leonard, Clair Gallagher, Michael R. Chicoine, Garnette R. Sutherland, John R. W. Kestle, S. Hassan Akbari, Randy L. Jensen
INTRODUCTION: Gliomas in pediatric patients remain challenging to treat. Intraoperative MRI (iMRI) may be a method to improve resection volumes, avoid critical structures, and guide intraoperative therapy in real-time. METHODS: We analyzed pediatric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba26c4e55125d1a950d3ac6d1d1e5fb
https://europepmc.org/articles/PMC6012111/
https://europepmc.org/articles/PMC6012111/