Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy

Autor: Matt Jones, Krasimira Tsaneva-Atanasova, Jonathan Witton, Andrew D. Randall, Jakub Nowacki, Clair A. Booth, J Brown

Publikováno v: Booth, C A, Witton, J, Nowacki, J, Tsaneva-Atanasova, K, Jones, M W, Randall, A D & Brown, J T 2016, ' Altered intrinsic pyramidal neuron properties and pathway-specific synaptic dysfunction underlie aberrant hippocampal network function in a mouse model of tauopathy ', Journal of Neuroscience, vol. 36, no. 2, pp. 350-363 . https://doi.org/10.1523/JNEUROSCI.2151-15.2016

The formation and deposition of tau protein aggregates is proposed to contribute to cognitive impairments in dementia by disrupting neuronal function in brain regions, including the hippocampus. We used a battery ofin vivoandin vitroelectrophysiologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593615b0d7a79d1e3379cef1f134cdb5
https://doi.org/10.1523/jneurosci.2151-15.2016

Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy

Autor: Andrew D. Randall, Emily de Groot, Mark A Ward, Marc Goodfellow, Keith G. Phillips, Thomas Ridler, Clair A. Booth, Jonathan T. Brown, Tracey K. Murray

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(2)

The entorhinal cortex (EC) is one of the first areas to be disrupted in neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. The responsiveness of individual neurons to electrical and environmental stimuli varies along

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acef7b98698a0cc95b31cb9c540ac9de
https://pubmed.ncbi.nlm.nih.gov/26758825

Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons

Autor: Jon T, Brown, Clair A, Booth, Andrew D, Randall

Publikováno v: The European journal of neuroscience. 33(5)

Burst firing is an important property of hippocampal pyramidal neurons. Group I metabotropic glutamate receptors (mGluRs) produce a multitude of effects on both the synaptic and intrinsic properties of neurons. We investigated whether brief activatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7c65a4ff0674c528bda4c2f82e6b13b
https://pubmed.ncbi.nlm.nih.gov/21269340