Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Claiborne M. Christian"'
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82021 (2013)
Long INterspersed Element-1 (LINE-1, L1) is an active retrotransposon that mobilizes using a ribonucleoprotein particle (RNP) intermediate composed of the full-length bicistronic L1 mRNA and the two proteins (ORF1p and ORF2p) encoded by that mRNA. OR
Externí odkaz:
https://doaj.org/article/1331540a45de49adaed57c7d47790a6a
Publikováno v:
Nucleic Acids Research
Long interspersed element 1 (L1) is an autonomous non-LTR retroelement that is active in mammalian genomes. Although retrotranspositionally incompetent and functional L1 loci are present in the same genomes, it remains unknown whether non-functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f2ac4ada09982b5bfad26acde5bdc6
http://europepmc.org/articles/PMC5605252
http://europepmc.org/articles/PMC5605252
Autor:
Claiborne M. Christian, Victoria P. Belancio, Dawn deHaro, Kristine J. Kines, Mark Sokolowski
Publikováno v:
Genetics. 205:1139-1149
Long interspersed element 1 (L1) is the only currently active autonomous retroelement in the human genome. Along with the parasitic SVA and short interspersed element Alu, L1 is the source of DNA damage induced by retrotransposition: a copy-and-paste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73863d0130708fb3e37b406a33f41cc
https://doi.org/10.1534/genetics.116.191403
https://doi.org/10.1534/genetics.116.191403
Autor:
Victoria P. Belancio, Kristine J. Kines, Claiborne M. Christian, Mark Sokolowski, Dawn deHaro
Publikováno v:
Nucleic Acids Research
Long Interspersed Element 1 (LINE-1 or L1) is capable of causing genomic instability through the activity of the L1 ORF2 protein (ORF2p). This protein contains endonuclease (EN) and reverse transcriptase (RT) domains that are necessary for the retrot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967ab0083bae3e2dbb53c23ca70fb395
http://europepmc.org/articles/PMC4889948
http://europepmc.org/articles/PMC4889948
Publikováno v:
Cancer Research. 78:B27-B27
Purpose: The human retrotransposon Long Interspersed Element 1 (L1) can contribute to genomic instability through de novo retrotransposition events, some of which could be mutagenic. L1 has long been considered to have a role in a variety of human di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05a1a80f63dabfa1a1fe3413edc3469b
https://doi.org/10.1158/1538-7445.mousemodels17-b27
https://doi.org/10.1158/1538-7445.mousemodels17-b27
Autor:
Madison E. Smither, Dawn deHaro, Claiborne M. Christian, Mark Sokolowski, Melody Baddoo, Kristine J. Kines, Victoria P. Belancio
Publikováno v:
Mobile DNA
Background Approximately 17 % of the human genome is comprised of the Long INterspersed Element-1 (LINE-1 or L1) retrotransposon, the only currently active autonomous family of retroelements. Though L1 elements have helped to shape mammalian genome e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd1e2d721989865321dfa2fbcad817e
https://pubmed.ncbi.nlm.nih.gov/27099633
https://pubmed.ncbi.nlm.nih.gov/27099633
Autor:
Dawn deHaro, Claiborne M. Christian, Mark Sokolowski, Kristine J. Kines, Victoria P. Belancio
Publikováno v:
Nucleic Acids Research
Expression of the L1 retrotransposon can damage the genome through insertional mutagenesis and the generation of DNA double-strand breaks (DSBs). The majority of L1 loci in the human genome are 5'-truncated and therefore incapable of retrotranspositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9fa595333b9bc24bd38de6da2f710f
https://pubmed.ncbi.nlm.nih.gov/25143528
https://pubmed.ncbi.nlm.nih.gov/25143528
Publikováno v:
Mobile Genetic Elements
The Long Interspersed Element 1 (LINE1 or L1) ORF2 protein (ORF2p) can cause DNA damage through the activity of its endonuclease domain (EN). The DNA double-strand breaks (DSB) introduced by the ORF2p EN have the potential to be mutagenic. Previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27bed5e878e0b250b582dca8e378253
https://doi.org/10.1080/2159256x.2016.1198300
https://doi.org/10.1080/2159256x.2016.1198300
Autor:
Kristine J. Kines, Dawn deHaro, Mark Sokolowski, Claiborne M. Christian, Victoria P. Belancio
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82021 (2013)
PLoS ONE
PLoS ONE
Long INterspersed Element-1 (LINE-1, L1) is an active retrotransposon that mobilizes using a ribonucleoprotein particle (RNP) intermediate composed of the full-length bicistronic L1 mRNA and the two proteins (ORF1p and ORF2p) encoded by that mRNA. OR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510b780ba77ad98b77d0a628654815db
https://doi.org/10.1371/journal.pone.0082021
https://doi.org/10.1371/journal.pone.0082021