Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Claes Andréasson"'
Autor:
Melania Minoia, Jany Quintana-Cordero, Katharina Jetzinger, Ilgin Eser Kotan, Kathryn Jane Turnbull, Michela Ciccarelli, Anna E. Masser, Dorina Liebers, Eloïse Gouarin, Marius Czech, Vasili Hauryliuk, Bernd Bukau, Günter Kramer, Claes Andréasson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Cotranslational protein folding depends on general chaperones that engage highly diverse nascent chains at the ribosomes. Here we discover a dedicated ribosome-associated chaperone, Chp1, that rewires the cotranslational folding machinery to
Externí odkaz:
https://doaj.org/article/f23814c7fcb4463299135165d37e841c
Autor:
Verena Kohler, Andreas Kohler, Lisa Larsson Berglund, Xinxin Hao, Sarah Gersing, Axel Imhof, Thomas Nyström, Johanna L. Höög, Martin Ott, Claes Andréasson, Sabrina Büttner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The resilience of cellular proteostasis declines with age, which drives protein aggregation and compromises viability. The nucleus has emerged as a key quality control compartment that handles misfolded proteins produced by the cytosolic pro
Externí odkaz:
https://doaj.org/article/5dbf4037911449959b5703bfa8fbcbd3
Autor:
Verena Kohler, Claes Andréasson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
While proteins populating their native conformations constitute the functional entities of cells, protein aggregates are traditionally associated with cellular dysfunction, stress and disease. During recent years, it has become clear that large aggre
Externí odkaz:
https://doaj.org/article/c67cf7a3a05d46ffb097fb78b50266dd
Autor:
Sarah K Gersing, Yong Wang, Martin Grønbæk-Thygesen, Caroline Kampmeyer, Lene Clausen, Martin Willemoës, Claes Andréasson, Amelie Stein, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009539 (2021)
Canavan disease is a severe progressive neurodegenerative disorder that is characterized by swelling and spongy degeneration of brain white matter. The disease is genetically linked to polymorphisms in the aspartoacylase (ASPA) gene, including the su
Externí odkaz:
https://doaj.org/article/5a6704a5a3084b048fd91b196f25c0dc
Autor:
Anna E Masser, Wenjing Kang, Joydeep Roy, Jayasankar Mohanakrishnan Kaimal, Jany Quintana-Cordero, Marc R Friedländer, Claes Andréasson
Publikováno v:
eLife, Vol 8 (2019)
Hsf1 is an ancient transcription factor that responds to protein folding stress by inducing the heat-shock response (HSR) that restore perturbed proteostasis. Hsp70 chaperones negatively regulate the activity of Hsf1 via stress-responsive mechanisms
Externí odkaz:
https://doaj.org/article/da724e3aabc248c09d454e29b0a18d68
Autor:
Tamara Suhm, Lukas Habernig, Magdalena Rzepka, Jayasankar Mohanakrishnan Kaimal, Claes Andréasson, Sabrina Buettner, Martin Ott
Publikováno v:
Microbial Cell, Vol 5, Iss 3, Pp 158-164 (2018)
The mitochondrial genome is responsible for the production of a handful of polypeptides that are core subunits of the membrane-bound oxidative phosphorylation system. Until now the mechanistic studies of mitochondrial protein synthesis inside cells h
Externí odkaz:
https://doaj.org/article/edadacf5656247bbaefb62b1027d7ff6
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e64870 (2013)
Modern biology research requires simple techniques for efficient and restriction site-independent modification of genetic material. Classical cloning and mutagenesis strategies are limited by their dependency on restriction sites and the use of compl
Externí odkaz:
https://doaj.org/article/55bcb512f0aa46b9ba220b775493a9e1
Autor:
Claes Andréasson, Anna J Schick, Susanne M Pfeiffer, Mihail Sarov, Francis Stewart, Wolfgang Wurst, Joel A Schick
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74207 (2013)
Efficient gene targeting in embryonic stem cells requires that modifying DNA sequences are identical to those in the targeted chromosomal locus. Yet, there is a paucity of isogenic genomic clones for human cell lines and PCR amplification cannot be u
Externí odkaz:
https://doaj.org/article/ccb6c25f3a2541a9856581f5a13f4a6b
Autor:
Heather Sadlish, Heike Rampelt, James Shorter, Renee D Wegrzyn, Claes Andréasson, Susan Lindquist, Bernd Bukau
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1763 (2008)
The cytosolic chaperone network of Saccharomyces cerevisiae is intimately associated with the emergence and maintenance of prion traits. Recently, the Hsp110 protein, Sse1, has been identified as a nucleotide exchange factor (NEF) for both cytosolic
Externí odkaz:
https://doaj.org/article/66b7b14b77704bdfaf67fe11ba3e673d
Autor:
Michela Ciccarelli, Anna E. Masser, Jayasankar Mohanakrishnan Kaimal, Jordi Planells, Claes Andréasson
Heat Shock Factor 1 (Hsf1) in yeast drives the basal transcription of key proteostasis factors and its activity is induced as part of the core heat shock response. Exploring Hsf1 specific functions has been challenging due to the essential nature of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82e0d2c13682b91088461b43706b009c
https://doi.org/10.1101/2023.05.05.539545
https://doi.org/10.1101/2023.05.05.539545