Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through Application of an “Agreement Docking” Method

Autor: Barker, M., Clackers, M., Demaine, D. A., Humphreys, D., Johnston, M. J., Jones, H. T., Pacquet, F., Pritchard, J. M., Salter, M., Shanahan, S. E., Skone, P. A., Vinader, V. M., Uings, I., McLay, I. M., Macdonald, S. J. F.

Publikováno v: Journal of Medicinal Chemistry; July 2005, Vol. 48 Issue: 14 p4507-4510, 4p

Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivity.

Autor: Biggadike K; ri CEDD, GlaxoSmithKline Medicines Research Centre, Stevenage, UK., Boudjelal M, Clackers M, Coe DM, Demaine DA, Hardy GW, Humphreys D, Inglis GG, Johnston MJ, Jones HT, House D, Loiseau R, Needham D, Skone PA, Uings I, Veitch G, Weingarten GG, McLay IM, Macdonald SJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2007 Dec 27; Vol. 50 (26), pp. 6519-34. Date of Electronic Publication: 2007 Nov 27.

Dissociated nonsteroidal glucocorticoid receptor modulators; discovery of the agonist trigger in a tetrahydronaphthalene-benzoxazine series.

Autor: Barker M; RI CEDD, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom., Clackers M, Copley R, Demaine DA, Humphreys D, Inglis GG, Johnston MJ, Jones HT, Haase MV, House D, Loiseau R, Nisbet L, Pacquet F, Skone PA, Shanahan SE, Tape D, Vinader VM, Washington M, Uings I, Upton R, McLay IM, Macdonald SJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2006 Jul 13; Vol. 49 (14), pp. 4216-31.

Synthesis of 6H-1,2-oxazin-6-ones (microreview).

Autor: Nizovtsev, Alexey V.¹ (AUTHOR) alexey.nizovtsev@gmail.com, Baranov, Mikhail S.^1,2 (AUTHOR)

Publikováno v: Chemistry of Heterocyclic Compounds. 2020, Vol. 56 Issue 10, p1280-1282. 3p.

Understanding how long-acting β2 -adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update.

Autor: Newton, Robert¹ rnewton@ucalgary.ca, Giembycz, Mark A²

Publikováno v: British Journal of Pharmacology. Dec2016, Vol. 173 Issue 24, p3405-3430. 26p. 2 Charts, 6 Graphs.