Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Clévio Nobrega"'
Autor:
Lígia Sousa-Ferreira, Manuel Garrido, Isabel Nascimento-Ferreira, Clévio Nobrega, Ana Santos-Carvalho, Ana Rita Alvaro, Joana Rosmaninho-Salgado, Manuella Kaster, Sebastian Kügler, Luís Pereira de Almeida, Claudia Cavadas
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22333 (2011)
Neuropeptide Y (NPY) produced by arcuate nucleus (ARC) neurons has a strong orexigenic effect on target neurons. Hypothalamic NPY levels undergo wide-ranging oscillations during the circadian cycle and in response to fasting and peripheral hormones (
Externí odkaz:
https://doaj.org/article/1e57eedd30f442f78020be3db427627d
Autor:
Filipa Esteves, David Brito, Ana Teresa Rajado, Nádia Silva, Joana Apolónio, Vânia Palma Roberto, Raquel P. Andrade, Sofia Calado, Maria Leonor Faleiro, Carlos Matos, Nuno Marques, Ana Marreiros, Hipólito Nzwalo, Sandra Pais, Isabel Palmeirim, Sónia Simãoa, Natércia Joaquim, Rui Miranda, António Pêgas, Daniela Marques Raposo, Ana Sardo, Inês Araújo, Clévio Nóbrega, Pedro Castelo-Branco, José Bragança
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103576- (2024)
Human induced pluripotent stem cells (hiPSCs) hold promises to model and understand human diseases, including those associated with ageing. Here, we describe ABCRIi001-A, a hiPSC line generated from peripheral blood mononuclear cells (PBMCs) of a 79-
Externí odkaz:
https://doaj.org/article/4e4ad26d812948cea921b6e4dafd8d40
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-14 (2024)
Abstract A CAG repeat sequence in the ATXN2 gene encodes a polyglutamine (polyQ) tract within the ataxin-2 (ATXN2) protein, showcasing a complex landscape of functions that have been progressively unveiled over recent decades. Despite significant pro
Externí odkaz:
https://doaj.org/article/33ff86d0fabc4a4fb8718e6f4a6e1771
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Neurodegenerative diseases are characterized by extensive loss of function or death of brain cells, hampering the life quality of patients. Brain-targeted drug delivery is challenging, with a low success rate this far. Therefore, the applica
Externí odkaz:
https://doaj.org/article/b9a96212d3db4fe493515c82e381c731
This is a reference handbook for young researchers exploring gene and cell therapy. Gene therapy could be defined as a set of strategies modifying gene expression or correcting mutant/defective genes through the administration of DNA (or RNA) to cell
This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies'development and progression, and (2) the therapeutic strategies that are currently being expl
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 179-182 (2022)
The accumulation of misfolded proteins and fibrillar aggregates inside neurons is a hallmark of several neurodegenerative diseases. While the exact role of these aggregates is still controversial, they are part of a cascade of molecular events that u
Externí odkaz:
https://doaj.org/article/749072f1589a4d0fb87ec4e54aafff91
Autor:
Clévio Nóbrega, Raquel Rodriguez-López
Obesity is a multi-factorial disease, in which an excess of accumulated body fat can reach levels capable of affecting health. It results from an interplay between environmental factors, eating behavior, genes, epigenetics, and neuronal stimuli. The
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/2a9d6205006148c7ae5aec910765a848
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Externí odkaz:
https://doaj.org/article/bdd767871dbd4b0a8eb9bdf69f9cc614