Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Clévio, Nóbrega"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-14 (2024)
Abstract A CAG repeat sequence in the ATXN2 gene encodes a polyglutamine (polyQ) tract within the ataxin-2 (ATXN2) protein, showcasing a complex landscape of functions that have been progressively unveiled over recent decades. Despite significant pro
Externí odkaz:
https://doaj.org/article/33ff86d0fabc4a4fb8718e6f4a6e1771
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Neurodegenerative diseases are characterized by extensive loss of function or death of brain cells, hampering the life quality of patients. Brain-targeted drug delivery is challenging, with a low success rate this far. Therefore, the applica
Externí odkaz:
https://doaj.org/article/b9a96212d3db4fe493515c82e381c731
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 179-182 (2022)
The accumulation of misfolded proteins and fibrillar aggregates inside neurons is a hallmark of several neurodegenerative diseases. While the exact role of these aggregates is still controversial, they are part of a cascade of molecular events that u
Externí odkaz:
https://doaj.org/article/749072f1589a4d0fb87ec4e54aafff91
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/2a9d6205006148c7ae5aec910765a848
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Externí odkaz:
https://doaj.org/article/bdd767871dbd4b0a8eb9bdf69f9cc614
Autor:
Adriana Marcelo, Inês T. Afonso, Ricardo Afonso-Reis, David V. C. Brito, Rafael G. Costa, Ana Rosa, João Alves-Cruzeiro, Benedita Ferreira, Carina Henriques, Rui J. Nobre, Carlos A. Matos, Luís Pereira de Almeida, Clévio Nóbrega
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-13 (2021)
Abstract Spinocerebellar ataxia type 2 (SCA2) is an incurable and genetic neurodegenerative disorder. The disease is characterized by progressive degeneration of several brain regions, resulting in severe motor and non-motor clinical manifestations.
Externí odkaz:
https://doaj.org/article/b63aca6d2a754206b576ac751ce40616
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-17 (2021)
Abstract Stress granules (SGs) are membraneless cell compartments formed in response to different stress stimuli, wherein translation factors, mRNAs, RNA-binding proteins (RBPs) and other proteins coalesce together. SGs assembly is crucial for cell s
Externí odkaz:
https://doaj.org/article/92cd819c6aaa4904bb1e52a2965346a5
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 12, Pp 2695-2696 (2023)
Externí odkaz:
https://doaj.org/article/18a9efb147c442d28bc8a44fad05291c
Autor:
Rodrigo Paulino, Clévio Nóbrega
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7405 (2023)
Machado–Joseph disease (MJD) or spinocerebellar ataxia 3 (SCA3) is a rare, inherited, monogenic, neurodegenerative disease, and the most common SCA worldwide. MJD/SCA3 causative mutation is an abnormal expansion of the triplet CAG at exon 10 within
Externí odkaz:
https://doaj.org/article/59cf928f7cd144f4b0eca7c6ab4474be
Autor:
Clévio Nóbrega, André Conceição, Rafael G. Costa, Rebekah Koppenol, Raquel L. Sequeira, Ricardo Nunes, Sara Carmo-Silva, Adriana Marcelo, Carlos A. Matos, Sandrine Betuing, Jocelyne Caboche, Nathalie Cartier, Sandro Alves
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-9 (2020)
Abstract Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD). Following our previous studies in HD, in th
Externí odkaz:
https://doaj.org/article/34bd3c232ee348b6aee607030541dff4