Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Clémentine Halliez"'
Autor:
Vikash Chandra, Hazem Ibrahim, Clémentine Halliez, Rashmi B. Prasad, Federica Vecchio, Om Prakash Dwivedi, Jouni Kvist, Diego Balboa, Jonna Saarimäki-Vire, Hossam Montaser, Tom Barsby, Väinö Lithovius, Isabella Artner, Swetha Gopalakrishnan, Leif Groop, Roberto Mallone, Decio L. Eizirik, Timo Otonkoski
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The TYK2 gene is associated with development of type 1 diabetes. Here the authors show that TYK2 regulates β-cell development, but at the same time TYK2 inhibition in the islets prevents IFNα responses and enhances their survival against CD8+ T-cel
Externí odkaz:
https://doaj.org/article/1702551117374e95b0db57f6600d8e23
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
Type 1 diabetes (T1D) is a disease of both autoimmunity and β-cells. The β-cells play an active role in their own demise by mounting defense mechanisms that are insufficient at best, and that can become even deleterious in the long term. This compl
Externí odkaz:
https://doaj.org/article/5bd5e1277706435aa5cec975035df3b4
Publikováno v:
Diabetes
Diabetes, 2022, 71 (8), pp.1603-1610. ⟨10.2337/dbi21-0036⟩
Diabetes, 2022, 71 (8), pp.1603-1610. ⟨10.2337/dbi21-0036⟩
International audience; Recent reports have revived interest in the active role that β-cells may play in type 1 diabetes pathogenesis at different stages of disease. In some studies, investigators suggested an initiating role and proposed that type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2529621ffc8d5a34d499a711e2ab08a0
https://www.hal.inserm.fr/inserm-03834211
https://www.hal.inserm.fr/inserm-03834211
