Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Clément R. Bouton"'
Autor:
Paul F. McKay, Kai Hu, Anna K. Blakney, Karnyart Samnuan, Jonathan C. Brown, Rebecca Penn, Jie Zhou, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J. C. Lin, Christopher Barbosa, Ying K. Tam, Wendy S. Barclay, Robin J. Shattock
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Here, the authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titers in conval
Externí odkaz:
https://doaj.org/article/d121c83855b64dc7847d5eded42ee84e
Autor:
Timothy K. Soh, Colin T.R. Davies, Julia Muenzner, Leah M. Hunter, Henry G. Barrow, Viv Connor, Clément R. Bouton, Cameron Smith, Edward Emmott, Robin Antrobus, Stephen C. Graham, Michael P. Weekes, Colin M. Crump
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108235- (2020)
Summary: Herpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic analysis over the time course of herpes simplex virus 1 (HSV-1) infection was use
Externí odkaz:
https://doaj.org/article/73723e5686cb4a80b1a33e64aec4ccd2
Autor:
Wendy S. Barclay, Kai Hu, Anna K. Blakney, Paulo J. C. Lin, Christopher Barbosa, Jonathan C Brown, Karnyart Samnuan, Jie Zhou, Ying K. Tam, Robin J. Shattock, Paul F. McKay, Paul Rogers, Rebecca Penn, Clément R. Bouton, Krunal Polra
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Nature Communications
Nature Communications
The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanopar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359f8e3281c7d137f48d198dd60a974c
http://link.springer.com/article/10.1038/s41467-020-17409-9
http://link.springer.com/article/10.1038/s41467-020-17409-9
Autor:
Fabiana Quaglia, Giulia Russo, Annapina Russo, Tatiana Lovato, Cameron Alexander, Clément R. Bouton, Anna K. Blakney, Robin J. Shattock, Pratik Gurnani, Claudia Conte, Francesca Saviano
Publikováno v:
Journal of Materials Chemistry B
Gene therapies are undergoing a renaissance, primarily due to their potential for applications in vaccination for infectious diseases and cancers. Although the biology of these technologies is rapidly evolving, delivery strategies need to be improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566ac374122e6369a0e7512a764424ac
https://doi.org/10.1039/d0tb00942c
https://doi.org/10.1039/d0tb00942c
Autor:
Karnyart Samnuan, Robin J. Shattock, Clément R. Bouton, Paul F. McKay, Anna K. Blakney, Kai Hu
Publikováno v:
Molecular Therapy
Self-amplifying RNA (saRNA) is a cutting-edge platform for both nucleic acid vaccines and therapeutics. saRNA is self-adjuvanting, as it activates types I and III interferon (IFN), which enhances the immunogenicity of RNA vaccines but can also lead t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303bbef1113c2fc80c548be7f900f1c1
http://hdl.handle.net/10044/1/83786
http://hdl.handle.net/10044/1/83786
Publikováno v:
Nucleic Acids Research
5′ Cap structures are ubiquitous on eukaryotic mRNAs, essential for post-transcriptional processing, translation initiation and stability. Here we describe a biosensor designed to detect the presence of cap structures on mRNAs that is also sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9903580d92fe49843a325e332ef913
http://hdl.handle.net/10044/1/84675
http://hdl.handle.net/10044/1/84675
Autor:
Paul Rogers, Christopher Barbosa, Robin J. Shattock, Paul F. McKay, Clément R. Bouton, Lin Pj, Anna K. Blakney, Ying K. Tam, Karnyart Samnuan, Krunal Polra, Kai Hu
The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanopar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1db07659e7acd88a8fbcf9acc969de0
https://doi.org/10.1101/2020.04.22.055608
https://doi.org/10.1101/2020.04.22.055608
Autor:
Clément R. Bouton, Polina Deletic, Alan Sabirsh, Paul F. McKay, Robin J. Shattock, Marianne Ashford, Anna K. Blakney
Publikováno v:
Journal of Controlled Release
Messenger RNA (mRNA) represents a promising next-generation approach for both treatment and vaccination. Lipid based particles are one of the most investigated delivery systems for mRNA formulations. Here we explore how the complexing lipid affects u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ece6a1c8d1c2ca1314804c0eb1d8c41
Autor:
Pratik Gurnani, Jonathan Yeow, Clément R. Bouton, Anna K. Blakney, Molly M. Stevens, Robin J. Shattock, Cameron Alexander
Publikováno v:
Polymer Chemistry
Cationic polymers are widely used as materials to condense nucleic acids for gene-based therapies. These have been developed to mainly deliver DNA and RNA for cancer therapies but the ongoing COVID-19 pandemic has demonstrated an urgent need for new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1e9ff7d6cb5813f529d39695a07291
Autor:
Stephen C. Graham, Clément R. Bouton, Edward Emmott, Robin Antrobus, Cameron B. Smith, Colin Davies, Timothy K. Soh, Colin M. Crump, Henry G. Barrow, Michael P. Weekes, Viv Connor, Julia Muenzner
SummaryHerpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic analysis over a whole time-course of herpes simplex virus (HSV)-1 infection was use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb533b9e7ee0e38f5f2c10be15dec7d
https://doi.org/10.1101/729343
https://doi.org/10.1101/729343