Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Clément Naudin"'
Autor:
Maria Jesus Iglesias, Laura Sanchez-Rivera, Manal Ibrahim-Kosta, Clément Naudin, Gaëlle Munsch, Louisa Goumidi, Maria Farm, Philip M. Smith, Florian Thibord, Julia Barbara Kral-Pointner, Mun-Gwan Hong, Pierre Suchon, Marine Germain, Waltraud Schrottmaier, Philip Dusart, Anne Boland, David Kotol, Fredrik Edfors, Mine Koprulu, Maik Pietzner, Claudia Langenberg, Scott M. Damrauer, Andrew D. Johnson, Derek M. Klarin, Nicholas L. Smith, David M. Smadja, Margareta Holmström, Maria Magnusson, Angela Silveira, Mathias Uhlén, Thomas Renné, Angel Martinez-Perez, Joseph Emmerich, Jean-Francois Deleuze, Jovan Antovic, Jose Manuel Soria Fernandez, Alice Assinger, Jochen M. Schwenk, Joan Carles Souto Andres, Pierre-Emmanuel Morange, Lynn Marie Butler, David-Alexandre Trégouët, Jacob Odeberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction
Externí odkaz:
https://doaj.org/article/c60db97f387c490db06b926e375c503c
Autor:
Maria Jesus Iglesias, Laura Sanchez-Rivera, Manal Ibrahim-Kosta, Clément Naudin, Gaëlle Munsch, Louisa Goumidi, Maria Farm, Philip M. Smith, Florian Thibord, Julia Barbara Kral-Pointner, Mun-Gwan Hong, Pierre Suchon, Marine Germain, Waltraud Schrottmaier, Philip Dusart, Anne Boland, David Kotol, Fredrik Edfors, Mine Koprulu, Maik Pietzner, Claudia Langenberg, Scott M. Damrauer, Andrew D. Johnson, Derek M. Klarin, Nicholas L. Smith, David M. Smadja, Margareta Holmström, Maria Magnusson, Angela Silveira, Mathias Uhlén, Thomas Renné, Angel Martinez-Perez, Joseph Emmerich, Jean-Francois Deleuze, Jovan Antovic, Jose Manuel Soria Fernandez, Alice Assinger, Jochen M. Schwenk, Joan Carles Souto Andres, Pierre-Emmanuel Morange, Lynn Marie Butler, David-Alexandre Trégouët, Jacob Odeberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/10828cb1b6164088b38dcda63f634aab
Autor:
Marco Heestermans, Clément Naudin, Reiner K. Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Manuel A. Friese, Mathias Gelderblom, Albert Sickmann, Roger J. S. Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M. Butler, Ophira Salomon, Evi X. Stavrou, Thomas Renné
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the
Externí odkaz:
https://doaj.org/article/23842f92b8124cd4863e0db2254038e6
Autor:
Mônica L Vieira, Clément Naudin, Matthias Mörgelin, Eliete C Romero, Ana Lucia T O Nascimento, Heiko Herwald
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004713 (2016)
Leptospirosis is a worldwide spread zoonotic and neglected infectious disease of human and veterinary concern that is caused by pathogenic Leptospira species. In severe infections, hemostatic impairments such as coagulation/fibrinolysis dysfunction a
Externí odkaz:
https://doaj.org/article/fef4cbd6c2504e62b6d7f4988b062962
Autor:
Clément Naudin, Alix Joulin-Giet, Gérard Couetdic, Patrick Plésiat, Aneta Szymanska, Emilia Gorna, Francis Gauthier, Franciszek Kasprzykowski, Fabien Lecaille, Gilles Lalmanach
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25577 (2011)
Cysteine cathepsins have emerged as new players in inflammatory lung disorders. Their activities are dramatically increased in the sputum of cystic fibrosis (CF) patients, suggesting that they are involved in the pathophysiology of CF. We have charac
Externí odkaz:
https://doaj.org/article/5a17670a2c5d47e4a1e8bb6f0f3b4555
Autor:
Lynn M. Butler, Roger J. S. Preston, Mathias Gelderblom, Evi X. Stavrou, Sandra Konrath, Thomas Renné, Stefan Rose-John, Carsten Deppermann, Giordano Pula, Clément Naudin, Anne Jämsä, Piotr Kuta, Marco Heestermans, Kristin Klaetschke, Albert Sickmann, Jerzy-Roch Nofer, Manuel A. Friese, Reiner K. Mailer, Ophira Salomon, Maike Frye
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic impli
Autor:
Laura Sanchez-Rivera, Maria Jesus Iglesias, Manal Ibrahim-Kosta, Julia Barbara Kral-Pointner, Sebastian Havervall, Louisa Goumidi, Maria Farm, Gaëlle Munsch, Marine Germain, Philip Smith, Mun-Gwan Hong, Pierre Suchon, Clément Naudin, Anne Boland, David M Smadja, Margareta Holmström, Maria Magnusson, Angela Silveira, Mathias Uhlén, Thomas Renné, Angel Martinez-Perez, Joseph Emmerich, Jean-Francois Deleuze, Jovan Antovic, Alice Assinger, Jose Manuel Soria Fernandez, Charlotte Thålin, Jochen M Schwenk, Juan Carlos Souto Andres, Pierre-Emmanuel Morange, Lynn Marie Butler, David-Alexandre Trégouët, Jacob Odeberg
Venous thromboembolism (VTE), comprising both deep vein thrombosis (DVT) and pulmonary embolism (PE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea1d22e1015b26cc2a5e7c0029ebbb16
https://doi.org/10.1101/2022.04.20.22274046
https://doi.org/10.1101/2022.04.20.22274046
Autor:
Madlen Rossnagel, Praveen Papareddy, Gülcan Kilic, Heiko Herwald, Cristina Novembrino, Srinivas Veerla, Femke Doreen Hollwedel, María Eugenia de la Morena-Barrio, Maria Abbattista, Ida Martinelli, Gopinath Kasetty, Andrea Artoni, Javier Corral, Arne Egesten, Irene Martínez-Martínez, Emanuel Smeds, Cord Brakebusch, Adam Linder, Clément Naudin, Johannes Westman
Publikováno v:
Nature Microbiology. 4:2442-2455
Severe infectious diseases are often characterized by an overwhelming and unbalanced systemic immune response to microbial infections. Human antithrombin (hAT) is a crucial coagulation inhibitor with anti-inflammatory activities. Here we identify thr
The plasma contact system, a protease cascade at the nexus of inflammation, coagulation and immunity
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1864:2118-2127
The contact system is a potent procoagulant and proinflammatory plasma protease cascade that is initiated by binding ("contact")-induced, auto-activation of factor XII zymogen. Formed active serine protease FXIIa then cleaves plasma prekallikrein to
Publikováno v:
Seminars in Thrombosis and Hemostasis. 43:814-826
Contact activation is the surface-induced conversion of factor XII (FXII) zymogen to the serine protease FXIIa. Blood-circulating FXII binds to negatively charged surfaces and this contact to surfaces triggers a conformational change in the zymogen i