Výsledky vyhledávání - "Clément N. David"

Akademický článek

SPARC coordinates extracellular matrix remodeling and efficient recruitment to and migration of antigen-specific T cells in the brain following infection

Autor: Kathryn E. McGovern, J. Philip Nance, Clément N. David, Reed E. S. Harrison, Shahani Noor, Danielle Worth, Tyler A. Landrith, Andre Obenaus, Monica J. Carson, Dimitrios Morikis, Emma H. Wilson

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)

Abstract Central nervous system (CNS) injury and infection can result in profound tissue remodeling in the brain, the mechanism and purpose of which is poorly understood. Infection with the protozoan parasite Toxoplasma gondii causes chronic infectio

Externí odkaz: https://doaj.org/article/37ea326e19414df5ac396cbe47c69847

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Akademický článek

Antitumor Activity of a Polypyridyl Chelating Ligand: and Inhibition of Glioma

Autor: Clément N. David, Elma S. Frias, Catherine C. Elix, Kathryn E. McGovern, Ameae M. Walker, Jack F. Eichler, Emma H. Wilson

Publikováno v: ASN Neuro, Vol 7 (2015)

Glioblastoma multiforme is an extremely aggressive and invasive form of central nervous system tumor commonly treated with the chemotherapeutic drug Temozolomide. Unfortunately, even with treatment, the median survival time is less than 12 months. 2,

Externí odkaz: https://doaj.org/article/f7584b0223af48b2b0a617401bd7f056

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Gene Expression Analysis in Four Dogs With Canine Pemphigus Clinical Subtypes Reveals B Cell Signatures and Immune Activation Pathways Similar to Human Disease

Autor: Ramón M. Almela, Diana Junyue Ma, Haya S. Raef, Nicholas A. Robinson, Cesar Piedra-Mora, Jillian M. Richmond, Neil B. Wong, Clément N. David

Publikováno v: Frontiers in Medicine
Frontiers in Medicine, Vol 8 (2021)

Pemphigus is a group of autoimmune-mediated mucocutaneous blistering diseases characterized by acantholysis. Pemphigus has also been recognized in dogs and shares similar clinical characteristics and variants with human pemphigus. While relationships

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3672aa0d14b04d93cb4a5109b1990c32
http://europepmc.org/articles/PMC8511432

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Targeted Transcriptomic Analysis of C57BL/6 and BALB/c Mice During Progressive Chronic Toxoplasma gondii Infection Reveals Changes in Host and Parasite Gene Expression Relating to Neuropathology and Resolution

Autor: Kristina V Bergersen, Ashli Barnes, Emma H. Wilson, Danielle Worth, Clément N. David

Publikováno v: Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Toxoplasma gondii is a resilient parasite that infects a multitude of warm-blooded hosts and results in a lifelong chronic infection requiring continuous responses by the host. Chronic infection is characterized by a balanced immune response and neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a18c398e6d4d5c371ea8b225cdaa3d7
https://doi.org/10.3389/fcimb.2021.645778

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SPARC coordinates extracellular matrix remodeling and efficient recruitment to and migration of antigen-specific T cells in the brain following infection

Autor: Clément N. David, Monica J. Carson, J. Philip Nance, Tyler A. Landrith, Emma H. Wilson, Kathryn E. McGovern, Shahani Noor, Andre Obenaus, Dimitrios Morikis, Danielle Worth, Reed E.S. Harrison

Publikováno v: Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)

Central nervous system (CNS) injury and infection can result in profound tissue remodeling in the brain, the mechanism and purpose of which is poorly understood. Infection with the protozoan parasite Toxoplasma gondii causes chronic infection and inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a957924866a78b906782fad6aad0629
http://europepmc.org/articles/PMC7907143

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Shared inflammatory and skin-specific gene signatures reveal common drivers of discoid lupus erythematosus in canines, humans and mice

Autor: Neil B. Wong, Clément N. David, Ramón M. Almela, Colton J. Garelli, Jillian M. Richmond, Linda M. Wrijil, Nicholas A. Robinson, Cesar Piedra-Mora, Gina Scarglia

Publikováno v: Current Research in Immunology, Vol 2, Iss, Pp 41-51 (2021)

Autoimmune skin diseases are complex and are thought to arise from a combination of genetics and environmental exposures, which trigger an ongoing immune response against self-antigens. Companion animals including cats and dogs are known to develop i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84836c545ea0717a9f8777ac2611411a
https://pubmed.ncbi.nlm.nih.gov/35492392

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Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

Autor: Colton J. Garelli, Jillian M. Richmond, Ista A. Egbeto, Neil B. Wong, Clément N. David, Nicholas A. Robinson, Cesar Piedra-Mora

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)

Vogt-Koyanagi-Harada syndrome (VKH) and vitiligo are autoimmune diseases that target melanocytes. VKH affects several organs such as the skin, hair follicle, eyes, ears, and meninges, whereas vitiligo is often limited to the skin and mucosa. Many stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c694317cfd42dc44a351db6d58f8cc98
https://pubmed.ncbi.nlm.nih.gov/33384688

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Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19

Autor: Marta Vuerich, Ahmadreza Kalbasi, Eric M. Miller, Na Wang, Simon C. Robson, Eva Csizmadia, Ann E. Woolley, Jonathon J. Graham, Zachary Manickas-Hill, Kara Gorman, Maria Serena Longhi, Clément N. David, Jonathan L. Hecht, Shahzad Shaefi

Publikováno v: iScience
iScience, Vol 24, Iss 10, Pp 103205-(2021)

T cell exhaustion and dysfunction are hallmarks of severe COVID-19. To gain insights into the pathways underlying these alterations, we performed a comprehensive transcriptome analysis of peripheral-blood-mononuclear-cells (PBMCs), spleen, lung, kidn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8b6bd06089a35e7ee0358082999495
https://doi.org/10.1016/j.isci.2021.103205

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NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

Autor: Clément N. David, Leslie Freeman, Haitao Guo, Sushmita Jha, Jenny P.-Y. Ting, W. June Brickey

Publikováno v: The Journal of Experimental Medicine

Lysophosphatidylcholine is associated with neurodegeneration and demyelination. Freeman et al. demonstrate that lysophosphatidylcholine triggers NLRP3- and NLRC4-dependent inflammasome activation, and in a synergistic fashion, NLRP3 and NLRC4 contrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8157f68252e4f5d123513756afc7f64e
https://doi.org/10.1084/jem.20150237

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