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pro vyhledávání: '"Clément Monot"'
Autor:
Clément Monot, Monika Kuciak, Sébastien Viollet, Ashfaq Ali Mir, Caroline Gabus, Jean-Luc Darlix, Gaël Cristofari
Publikováno v:
PLoS Genetics, Vol 9, Iss 5, p e1003499 (2013)
L1 retrotransposons have a prominent role in reshaping mammalian genomes. To replicate, the L1 ribonucleoprotein particle (RNP) first uses its endonuclease (EN) to nick the genomic DNA. The newly generated DNA end is subsequently used as a primer to
Externí odkaz:
https://doaj.org/article/3abf58323ac740acae08d36d07928fb9
Publikováno v:
Mobile Genetic Elements
LINE-1 (L1) elements are the only active and autonomous transposable elements in humans. The core retrotransposition machinery is a ribonucleoprotein particle (RNP) containing the L1 mRNA, with endonuclease and reverse transcriptase activities. It in