Oxidative Damages on the Alzheimer’s Related-Aβ Peptide Alters Its Ability to Assemble

Autor: Clémence Cheignon, Fabrice Collin, Laurent Sabater, Christelle Hureau

Publikováno v: Antioxidants, Vol 12, Iss 2, p 472 (2023)

Oxidative stress that can lead to oxidation of the amyloid-β (Aβ) peptide is considered a key feature in Alzheimer’s disease (AD), influencing the ability of Aβ to assemble into β-sheet rich fibrils that are commonly found in senile plaques of

Externí odkaz: https://doaj.org/article/9c28fd1b111349cfafe2d04c162ca5d2

Bioconjugation studies of an EGF-R targeting ligand on dendronized iron oxide nanoparticles to target head and neck cancer cells

Autor: Barbara Freis, María De Los Ángeles Ramírez, Sonia Furgiuele, Fabrice Journe, Clémence Cheignon, Loïc J. Charbonnière, Céline Henoumont, Celine Kiefer, Damien Mertz, Christine Affolter-Zbaraszczuk, Florent Meyer, Sven Saussez, Sophie Laurent, Mariana Tasso, Sylvie Bégin-Colin

Publikováno v: International Journal of Pharmaceutics. 635:122654

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0818063619a64d0f7054a9b53d77f47c
https://doi.org/10.1016/j.ijpharm.2023.122654

Ultrabright Terbium Nanoparticles for FRET Biosensing and in Situ Imaging of Epidermal Growth Factor Receptors

Autor: Laura Francés-Soriano, Vjona Cifliku, Cyrille Charpentier, Clémence Cheignon, Joan Goetz, Aline Nonat, Loïc J. Charbonnière, Niko Hildebrandt, Ka-Leung Wong, Marcelina Cardoso Dos Santos

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, In press, ⟨10.1002/chem.202002007⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, 26 (64), pp.14602-14611. ⟨10.1002/chem.202002007⟩
Chemistry-A European Journal, 2020, 26 (64), pp.14602-14611. ⟨10.1002/chem.202002007⟩

International audience; Lanthanide‐doped nanoparticles (LnNPs) have become an important class of fluorophores for advanced biosensing and bioimaging. LnNPs that are photosensitized by surface‐attached antenna ligands can possess exceptional brigh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475153c0e3a688b250867e289bb2be5a
https://hal.archives-ouvertes.fr/hal-02965452

Receptor–Ligand Interaction Measured by Inductively Coupled Plasma Mass Spectrometry and Selenium Labeling

Autor: Nolween Prache, Jean Martinez, Gilles Subra, Sonia Cantel, Carine Arnaudguilhem, Clémence Cheignon, Christine Enjalbal, Brice Bouyssiere, Emmanuelle Cordeau

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (22), pp.10173-10184. ⟨10.1021/acs.jmedchem.8b01320⟩

International audience; In the search for an alternative strategy to the radioactivity measurement conventionally performed to probe receptor–ligand interactions in pharmacological assays, we demonstrated that selenium labeling of the studied ligan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013e19058cc2d206a9d6a5e27ad08055
https://hal.archives-ouvertes.fr/hal-02095370

Identification of key structural features of the elusive Cu-Aβ complex generating ROS in Alzheimer's Disease

Autor: Elena Atrián-Blasco, Christelle Hureau, Megan Jones, Fabrice Collin, Peter Faller, Isabelle Kieffer, Clémence Cheignon

Publikováno v: Chemical Science
Chemical Science, The Royal Society of Chemistry, 2017, 8 (7), pp.5107-5118. ⟨10.1039/c7sc00809k⟩
Chem. Sci.
Chemical Science, 2017, 8 (7), pp.5107-5118. ⟨10.1039/c7sc00809k⟩
'Chemical Science ', vol: 8, pages: 5107-5118 (2017)

International audience; Oxidative stress is linked to the etiology of Alzheimer’s disease (AD), the most common cause of dementia in the elderly. Redox active metal ions such as copper catalyze the production of Reactive Oxygen Species (ROS) when b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3999ffbfab8d0e169e45128958a72b
https://hal.archives-ouvertes.fr/hal-01591661/document