Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Cláudio M, Gomes"'
Autor:
Ivone M. Martins, Alexandre Lima, Wim de Graaff, Joana S. Cristóvão, Niek Brosens, Eleonora Aronica, Leon D. Kluskens, Cláudio M. Gomes, Joana Azeredo, Helmut W. Kessels
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-8 (2024)
Abstract Oligomeric clusters of amyloid-β (Aβ) are one of the major biomarkers for Alzheimer’s disease (AD). However, proficient methods to detect Aβ-oligomers in brain tissue are lacking. Here we show that synthetic M13 bacteriophages displayin
Externí odkaz:
https://doaj.org/article/2e0eb88b678d4731b983a499182ac95e
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/80d6d196e4254ffab49995ff18829d85
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Extracellular aggregation of the amyloid-β 1–42 (Aβ42) peptide is a major hallmark of Alzheimer’s disease (AD), with recent data suggesting that Aβ intermediate oligomers (AβO) are more cytotoxic than mature amyloid fibrils. Understanding how
Externí odkaz:
https://doaj.org/article/e656f11f01d541a6a7c75566c75e2882
Autor:
Eleonora Daini, Simone Hagmeyer, Chiara A. De Benedictis, Joana S. Cristóvão, Martina Bodria, Aisling M. Ross, Andrea Raab, Tobias M. Boeckers, Joerg Feldmann, Cláudio M. Gomes, Michele Zoli, Antonietta Vilella, Andreas M. Grabrucker
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Autism Spectrum Disorders (ASD) are caused by a combination of genetic predisposition and nongenetic factors. Among the nongenetic factors, maternal immune system activation and zinc deficiency have been proposed. Intriguingly, as a genetic
Externí odkaz:
https://doaj.org/article/e66884e838aa463eb9316b5178485c50
Autor:
Guilherme G. Moreira, François-Xavier Cantrelle, Andrea Quezada, Filipa S. Carvalho, Joana S. Cristóvão, Urmi Sengupta, Nicha Puangmalai, Ana P. Carapeto, Mário S. Rodrigues, Isabel Cardoso, Güenter Fritz, Federico Herrera, Rakez Kayed, Isabelle Landrieu, Cláudio M. Gomes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The calcium binding protein S100B is an abundantly expressed protein in the brain and has neuro-protective functions by inhibiting Aβ aggregation and metal ion toxicity. Here, the authors combine cell biology and biochemical experiments with chemica
Externí odkaz:
https://doaj.org/article/c84f299d39b043bfadec87ae6bbc7bf3
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Externí odkaz:
https://doaj.org/article/14804c0fdb0845f5bf5d7bf9ddbc1a40
Autor:
Pedro M. Martins, Susanna Navarro, Alexandra Silva, Maria F. Pinto, Zsuzsa Sárkány, Francisco Figueiredo, Pedro José Barbosa Pereira, Francisca Pinheiro, Zuzana Bednarikova, Michał Burdukiewicz, Oxana V. Galzitskaya, Zuzana Gazova, Cláudio M. Gomes, Annalisa Pastore, Louise C. Serpell, Rostislav Skrabana, Vytautas Smirnovas, Mantas Ziaunys, Daniel E. Otzen, Salvador Ventura, Sandra Macedo-Ribeiro
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Reports on phase separation and amyloid formation for multiple proteins and aggregation-prone peptides are recurrently used to explore the molecular mechanisms associated with several human diseases. The information conveyed by these reports can be u
Externí odkaz:
https://doaj.org/article/fc44793c97ba412084f310dcf7f683f9
Autor:
Simone Hagmeyer, Mariana A. Romão, Joana S. Cristóvão, Antonietta Vilella, Michele Zoli, Cláudio M. Gomes, Andreas M. Grabrucker
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Increasing evidence links proteins of the S100 family to the pathogenesis of Alzheimer’s disease (AD). S100 proteins are EF-hand calcium-binding proteins with intra- and extracellular functions related to regulation of proliferation, differentiatio
Externí odkaz:
https://doaj.org/article/84cb08fe8fdb46669f8abef03f1e226a
Autor:
Joana S. Cristóvão, Cláudio M. Gomes
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
S100 proteins are calcium-binding proteins that regulate several processes associated with Alzheimer’s disease (AD) but whose contribution and direct involvement in disease pathophysiology remains to be fully established. Due to neuroinflammation i
Externí odkaz:
https://doaj.org/article/572c730051ca4d51bb8370e173774383
Autor:
Joana S. Cristóvão, Mariana A. Romão, Rodrigo Gallardo, Joost Schymkowitz, Frederic Rousseau, Cláudio M. Gomes
Publikováno v:
Molecules, Vol 26, Iss 2, p 440 (2021)
S100 proteins assume a diversity of oligomeric states including large order self-assemblies, with an impact on protein structure and function. Previous work has uncovered that S100 proteins, including S100B, are prone to undergo β-aggregation under
Externí odkaz:
https://doaj.org/article/116c1ead73314414996be73bef19861a