Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Cláudia N Santos"'
Autor:
Sandra Tenreiro, Madalena M Reimão-Pinto, Pedro Antas, José Rino, Donata Wawrzycka, Diana Macedo, Rita Rosado-Ramos, Triana Amen, Meytal Waiss, Filipa Magalhães, Andreia Gomes, Cláudia N Santos, Daniel Kaganovich, Tiago Fleming Outeiro
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004302 (2014)
Alpha-synuclein (aSyn) is the main component of proteinaceous inclusions known as Lewy bodies (LBs), the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Although aSyn is phosphorylated at low levels under physio
Externí odkaz:
https://doaj.org/article/67a44edc2b0d4e2cab148e6ab173901e
Autor:
Rita Rosado-Ramos, Gonçalo M. Poças, Daniela Marques, Alexandre Foito, David M. Sevillano, Mafalda Lopes-da-Silva, Luís G. Gonçalves, Regina Menezes, Marcel Ottens, Derek Stewart, Alain Ibáñez de Opakua, Markus Zweckstetter, Miguel C. Seabra, César S. Mendes, Tiago Fleming Outeiro, Pedro M. Domingos, Cláudia N. Santos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
In this work, the authors identify Genipin as a small iridoid able to prevent alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Externí odkaz:
https://doaj.org/article/6e0052eb0e2b432c9b02cba0d241c7e9
Autor:
María-Carmen López de las Hazas, Joana Godinho-Pereira, Alba Macià, A. Filipa Almeida, M. Rita Ventura, Maria-José Motilva, Cláudia N. Santos
Publikováno v:
Journal of Functional Foods, Vol 46, Iss , Pp 110-117 (2018)
Hydroxytyrosol (HT) and oleuropein derivatives are the main phenolic compounds in virgin olive oil (VOO). After VOO intake, HT is extensively metabolized being hydroxytyrosol-sulphate (HT-S) and hydroxytyrosol-acetate sulphate (HT-AC-S) the main circ
Externí odkaz:
https://doaj.org/article/061f8853a1c9436492135d3232cb78e1
Autor:
Diana Macedo, Carolina Jardim, Inês Figueira, A. Filipa Almeida, Gordon J. McDougall, Derek Stewart, Jose E. Yuste, Francisco A. Tomás-Barberán, Sandra Tenreiro, Tiago F. Outeiro, Cláudia N. Santos
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Parkinson’s disease (PD) is an age-related neurodegenerative disease associated with the misfolding and aggregation of alpha-synuclein (aSyn). The molecular underpinnings of PD are still obscure, but nutrition may play an important role in
Externí odkaz:
https://doaj.org/article/b63714c237644fb09216d02bf2765b49
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11402 (2021)
(Poly)phenol-derived metabolites are small molecules resulting from (poly)phenol metabolization after ingestion that can be found in circulation. In the last decade, studies on the impact of (poly)phenol properties in health and cellular metabolism a
Externí odkaz:
https://doaj.org/article/5ef8962fd9314a03b559b9c5efb19787
Autor:
Carolina Jardim, Diana Macedo, Inês Figueira, Gary Dobson, Gordon J. McDougall, Derek Stewart, Ricardo B. Ferreira, Regina Menezes, Cláudia N. Santos
Publikováno v:
Journal of Functional Foods, Vol 32, Iss , Pp 333-346 (2017)
Oxidative stress is a key process in several diseases and a growing body of preclinical/clinical evidence has pushed forward the health benefits of (poly)phenols. The protective potential of Corema album and Arbutus unedo (Poly)phenol Digested Metabo
Externí odkaz:
https://doaj.org/article/7129294e6b06489f9bc1bacf4ab3a34f
Autor:
Diogo Carregosa, Inês P. Silva, Carolina Teixeira, Mariana Baltazar, Rocio García-Villalba, Filipa Soares Vieira, Mónica Marçal, Madalena Tuna, Cláudia N. Santos
Human breast milk is the first food source available to newborns and is responsible for healthy growth and development during the first months of life. Human breast milk contains vitamins, hormones, cytokines, microbiota, and immune cells that are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::635902142af27133ea0c151fffb1b3d2
https://doi.org/10.1101/2023.03.27.23287781
https://doi.org/10.1101/2023.03.27.23287781
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Unpaid care work, mostly performed by women, is a central but undervalued contributor to economies. During the COVID-19 pandemic, the need for unpaid care work increased due to restricted movement, social isolation, and economic challenges. This pand
Autor:
Diogo Carregosa, Regina Menezes, Katerina Valentova, Derek Stewart, Alexandre Foito, Gordon McDougall, Cláudia N. Santos
Publikováno v:
Dietary Polyphenols
Autor:
Ricardo B. Ferreira, Derek Stewart, Gordon McDougall, Paula M. Alves, Vera Pontes, Meenu Tyagi, Lucélia Tavares, Rui Pimpão, Sofia Fortalezas, Cláudia N. Santos
Publikováno v:
Nutrients, Vol 2, Iss 2, Pp 214-229 (2010)
Berries contain significant amounts of phytochemicals, including polyphenols, which are reported to reduce cancer risk, coronary heart disease and other degenerative diseases. These effects are mainly attributed to the antioxidant capacity of polyphe
Externí odkaz:
https://doaj.org/article/c899316fac0c41b8abdeab3ef59502e0