Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Cláudia A Valente"'
Autor:
Nádia Rei, Cláudia A Valente, Sandra H Vaz, Miguel Farinha-Ferreira, Joaquim A Ribeiro, Ana M Sebastião
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0272104 (2022)
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of corticospinal tract motor neurons. Previous studies showed that adenosine-mediated neuromodulation is disturbed in ALS and that vascular endothelial growth factor
Externí odkaz:
https://doaj.org/article/41c11bc5d5c842d09b96fcadda5bf6ca
Autor:
Rita F. Belo, Margarida L. F. Martins, Liana Shvachiy, Tiago Costa-Coelho, Carolina de Almeida-Borlido, João Fonseca-Gomes, Vera Neves, Hugo Vicente Miranda, Tiago F. Outeiro, Joana E. Coelho, Sara Xapelli, Cláudia A. Valente, Montserrat Heras, Eduard Bardaji, Miguel A. R. B. Castanho, Maria José Diógenes, Ana M. Sebastião
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer’s disease (AD). In fact, KTP levels were
Externí odkaz:
https://doaj.org/article/23add04407fb425ba6cdc74be1ceea14
Autor:
Fernanda Murtinheira, Mafalda Migueis, Ricardo Letra-Vilela, Mickael Diallo, Andrea Quezada, Cláudia A. Valente, Abel Oliva, Carmen Rodriguez, Vanesa Martin, Federico Herrera
Publikováno v:
Cells, Vol 11, Iss 2, p 299 (2022)
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disorder commonly diagnosed in infants and characterized by progressive cerebellar ataxia, spasticity, motor sensory neuropathy and axonal demyelination. ARSACS
Externí odkaz:
https://doaj.org/article/6fd608b093224589afbfc1a1550049a4
Autor:
Daniela M. Magalhães, Noémia Pereira, Diogo M. Rombo, Cláudia Beltrão-Cavacas, Ana M. Sebastião, Cláudia A. Valente
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-18 (2018)
Abstract Background Epilepsy is a prevalent neurological disorder worldwide. It is characterized by an enduring predisposition to generate seizures and its development is accompanied by alterations in many cellular processes. Organotypic slice cultur
Externí odkaz:
https://doaj.org/article/55ac221e3d5a4e73b6e40ca5627291a0
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2018)
In central nervous system, glycine receptor (GlyR) is mostly expressed in the spinal cord and brainstem, but glycinergic transmission related elements have also been identified in the brain. Astrocytes are active elements at the tripartite synapse, b
Externí odkaz:
https://doaj.org/article/c731c51a389341ddb13bd5f986c7996b
Publikováno v:
Journal of Alzheimer's Disease
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease commonly diagnosed among the elderly population. AD is characterized by the loss of synaptic connections, neuronal death, and progressive cognitive impairment, attributed to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00564507031c237a0d0dbb1747e1f08
https://doi.org/10.3233/jad-210268
https://doi.org/10.3233/jad-210268
Autor:
Nádia Rei, Cláudia A. Valente, Sandra H. Vaz, Miguel Farinha-Ferreira, Joaquim A. Ribeiro, Ana M. Sebastião
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of corticospinal tract motor neurons. Previous studies showed that adenosine-mediated neuromodulation is disturbed in ALS and that vascular endothelial growth factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::440f790b491cb5e3d865750dce2f418c
https://doi.org/10.1101/2022.07.14.500069
https://doi.org/10.1101/2022.07.14.500069
Publikováno v:
Biomolecules. 12:666
Astrocytes are the most abundant cells in the CNS parenchyma and play an essential role in several brain functions, such as the fine-tuning of synaptic transmission, glutamate uptake and the modulation of immune responses, among others. Much of the k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1502f3647fe666df460c7c3cad60b93c
https://doi.org/10.3390/biom12050666
https://doi.org/10.3390/biom12050666
Autor:
Ana M. Sebastião, Dilip K. Tosh, Cláudia A. Valente, Kenneth A. Jacobson, Joaquim A. Ribeiro, Leonor Ribeiro Rodrigues
Epilepsy is a common neurological disorder but resistance to pharmacotherapy makes it necessary the development of novel antiepileptic drugs (AEDs). An A1 adenosine receptor (A1R) agonist, MRS5474, possesses anticonvulsant activity in an animal model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::079c5da62b0a46e66d5544d7d627ddcd
https://doi.org/10.14293/s2199-1006.1.sor-.ppw4qmj.v1
https://doi.org/10.14293/s2199-1006.1.sor-.ppw4qmj.v1
Autor:
Ari Waisman, Tommy Regen, Bruno Manadas, Cláudia A. Valente, Paula A. Pousinha, Miguel Ribeiro, Cátia Santa, Julie C. Ribot, Brigitta Stockinger, Bruno Silva-Santos, Sara Omenetti, Joana E. Coelho, Luísa V. Lopes, Helena C. Brigas, Inês Marques-Morgado, Mariana Temido-Ferreira
Publikováno v:
Science Immunology
The notion of "immune privilege" of the brain has been revised to accommodate its infiltration, at steady state, by immune cells that participate in normal neurophysiology. However, the immune mechanisms that regulate learning and memory remain poorl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1940d12099eb8ccb1bd87f1e35f04a
https://europepmc.org/articles/PMC6894940/
https://europepmc.org/articles/PMC6894940/