Výsledky vyhledávání

Eradication of large human B cell tumors in nude mice with unconjugated CD20 monoclonal antibodies and interleukin 2

Autor: Erik Hooijberg, Jj, Sein, Pc, Den Berk, Aa, Hart, Ma, Valk, Wm, Kast, Cj, Melief, Hekman A

Publikováno v: Europe PubMed Central

Since antibody-dependent cellular cytotoxicity is considered an important mechanism by which mAbs may exert their antitumor effects, it seems likely that these antitumor effects can be enhanced by the activation of the appropriate effector cell popul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dea78bebb8bc45e70d4805b651005c6c
https://pubmed.ncbi.nlm.nih.gov/7540106

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Enhanced antitumor effects of CD20 over CD19 monoclonal antibodies in a nude mouse xenograft model

Autor: Erik Hooijberg, Pc, Den Berk, Jj, Sein, Wijdenes J, Aa, Hart, Rw, Boer, Cj, Melief, Hekman A

Publikováno v: Europe PubMed Central

We used a nude mouse xenograft tumor model to compare the efficacy of unconjugated CD19 and CD20 mAbs (IgG2a subclass) in mediating antilymphoma effects. Treatment with the CD20 mAbs NKI-B20 and BCA-B20 resulted in a drastic decrease in tumor take ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7bdab3a581e10283ade5cdb0eac8a642
https://pubmed.ncbi.nlm.nih.gov/7531616

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Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences

Autor: Neisig A, Roelse J, Alice Sijts, Ossendorp F, Mc, Feltkamp, Wm, Kast, Cj, Melief, Jj, Neefjes

Publikováno v: Europe PubMed Central

The MHC-encoded transporter associated with Ag presentation (TAP) translocates peptides from the cytosol to the ER lumen, where association with MHC class I molecules occurs. The MHC class I/peptide complex is subsequently transported to the cell sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::62320692635304c60d7e2076e67afa58
https://pubmed.ncbi.nlm.nih.gov/7822796

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Role of LFA-1 and VLA-4 in the adhesion of cloned normal and LFA-1 (CD11/CD18)-deficient T cells to cultured endothelial cells. Indication for a new adhesion pathway

Autor: Cj, Vennegoor, van de Wiel-van Kemenade E, Rj, Huijbens, Sanchez-Madrid F, Cj, Melief, Cg, Figdor

Publikováno v: Europe PubMed Central

Patients with the leukocyte adhesion deficiency (LAD) syndrome have a genetic defect in the common beta 2-chain (CD18) of the leukocyte integrins. This defect can result in the absence of cell surface expression of all three members of the leukocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9bf53d15392cc2ab3947ac7cb788fab1
https://pubmed.ncbi.nlm.nih.gov/1371131

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Treatment with monoclonal anti-CD3 antibody protects against lethal Sendai virus infection by induction of natural killer cells

Autor: Wm, Kast, Ja, Bluestone, Mh, Heemskerk, Joke Spaargaren, Ac, Voordouw, Jd, Ellenhorn, Cj, Melief

Publikováno v: Europe PubMed Central

C57BL/6 mice are protected from a lethal pneumonia caused by Sendai virus when treated with low doses of mAb directed to the CD3 Ag. The protective mechanism is not due to an accelerated Sendai virus-specific Th cell, CTL, or antibody response but to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::04488171c0c271968fdec5decd9ba420
http://europepmc.org/abstract/med/2168920

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Immunodominant mink cell focus-inducing murine leukemia virus (MuLV)-encoded CTL epitope, identified by its MHC class I-binding motif, explains MuLV-type specificity of MCF-directed cytotoxic T lymphocytes

Autor: Alice Sijts, Ossendorp F, Ea, Mengedé, Pj, Den Elsen, Cj, Melief

Publikováno v: Europe PubMed Central

H-2b mice are immunologic responders to the tumorigenic MCF1233 murine leukemia virus (MuLV), an AKV-related virus derived from endogenous C57BL MuLV. We have identified an immunodominant CTL epitope that is expressed on MCF1233 MuLV-induced lymphoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f07f9d26a51f22412e939d1279e0e447
http://europepmc.org/abstract/med/8254184

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Superior tumor protection induced by a cellular vaccine carrying a tumor-specific T helper epitope by genetic exchange of the class II-associated invariant chain peptide

Autor: van Bergen J, Camps M, Offringa R, Cj, Melief, Ossendorp F, Frits Koning

Publikováno v: Europe PubMed Central

Efficient loading of MHC class II molecules with a T helper epitope of choice can be achieved through genetic exchange of the MHC class II-associated invariant chain peptide (CLIP) sequence with a sequence encoding the helper peptide. We have now use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::000851add59d2f3724d6201fe71a9abb
http://europepmc.org/abstract/med/11103809

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Akademický článek

The expression profile of brain-derived exosomal miRNAs reveals the key molecules responsible for spontaneous motor function recovery in a rat model with permanent middle cerebral artery occlusion.

Autor: Liu L; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China., Chen S; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China., Liang S; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China., Liang Z; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China. lzj200415@126.com.

Publikováno v: Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2024 Sep; Vol. 35 (3), pp. 362-376. Date of Electronic Publication: 2024 Jul 12.

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