Zobrazeno 1 - 10 of 406 pro vyhledávání: '"Cj, Eaves"'
1
Alternative mechanisms with and without steel factor support primitive human hematopoiesis
Autor: HJ Sutherland, DE Hogge, D Cook, CJ Eaves
Publikováno v: Blood. 81:1465-1470
As a first approach to defining the molecular requirements for supporting human hematopoietic stem cell maintenance and differentiation in vitro, we have analyzed and compared the ability of various factors to support the maintenance and initial diff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8ccd1200f61e0ad625c8ff127eb0b39
https://doi.org/10.1182/blood.v81.6.1465.bloodjournal8161465
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2
Differential regulation of primitive human hematopoietic cells in long- term cultures maintained on genetically engineered murine stromal cells
Autor: HJ Sutherland, CJ Eaves, PM Lansdorp, JD Thacker, DE Hogge
Publikováno v: Blood. 78:666-672
Various growth factors are known to stimulate both early and late stages of human hematopoietic cell development in semisolid assay systems, but their role as microenvironmental regulators is poorly understood. To address this problem, we developed a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ae3e54c966b3f0f86762736805cab87
https://doi.org/10.1182/blood.v78.3.666.bloodjournal783666
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3
Transformation-associated alterations in interactions between pre-B cells and fibronectin
Autor: Fm, Lemoine, Shoukat Dedhar, Gm, Lima, Cj, Eaves
Publikováno v: Europe PubMed Central
Marrow stromal elements produce as yet uncharacterized soluble growth factors that can stimulate the proliferation of murine pre-B cells, although close contact between these two cell types appears to ensure a better pre-B cell response. We have now
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c23a609e10decbc5faa05bde8e0b47
https://doi.org/10.1182/blood.v76.11.2311.bloodjournal76112311
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5
The tetrapeptide AcSDKP specifically blocks the cycling of primitive normal but not leukemic progenitors in long-term culture: evidence for an indirect mechanism
Autor: JD Cashman, AC Eaves, CJ Eaves
Publikováno v: Blood. 84(5)
In the present study, we investigated the ability of the tetrapeptide NAc-Ser-Asp-Lys-Pro-OH (AcSDKP), a reported inhibitor of primitive hematopoietic cells, to influence the proliferative behavior of primitive normal and chronic myeloid leukemia (CM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4789d385edcd7eb2fe6510c6954269
https://pubmed.ncbi.nlm.nih.gov/8068944
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6
Kinetics of committed and primitive blood progenitor mobilization after chemotherapy and growth factor treatment and their use in autotransplants
Autor: HJ Sutherland, CJ Eaves, PM Lansdorp, GL Phillips, DE Hogge
Publikováno v: Blood. 83(12)
Peripheral blood cells (PBCs) collected by leukapheresis after progenitor mobilization with chemotherapy and growth factors have been used successfully to replace marrow autografts in protocols requiring stem-cell support. Moreover, such transplants
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4a588dfbc9ac9a4a0cd4912314b9cb
https://pubmed.ncbi.nlm.nih.gov/7911344
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7
Familial and congenital polycythemia in three unrelated families
Autor: PD Emanuel, CJ Eaves, VC Broudy, T Papayannopoulou, MR Moore, AD D'Andrea, JF Prchal, AC Eaves, JT Prchal
Publikováno v: Blood. 79(11)
Three families with polycythemia inherited through apparently different modes are described. Secondary causes of polycythemia were ruled out. Erythropoietin (EPO) levels were normal or low, even after phlebotomy. In vitro erythroid colony growth in s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdff2a36a1cbd1d2b4b792d3fa58943
https://pubmed.ncbi.nlm.nih.gov/1316790
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8
Increased erythropoietin-receptor expression on CD34-positive bone marrow cells from patients with chronic myeloid leukemia
Autor: AW Wognum, G Krystal, CJ Eaves, AC Eaves, PM Lansdorp
Publikováno v: Blood. 79(3)
Erythropoietin-receptor (EpR) expression on bone marrow cells from normal individuals and from patients with chronic myeloid leukemia (CML) was examined by multiparameter flow cytometry after stepwise amplified immunostaining with biotin-labeled Ep,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e52662c28eb0337e21661725dcb4eb
https://pubmed.ncbi.nlm.nih.gov/1370638
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9
Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer
Autor: CJ Eaves, JD Cashman, RJ Kay, GJ Dougherty, T Otsuka, LA Gaboury, DE Hogge, PM Lansdorp, AC Eaves, RK Humphries
Publikováno v: Blood. 78(1)
Numerous factors that can influence the proliferation and differentiation in vitro of cells at various stages of hematopoiesis have been identified, but the mechanisms used by stromal cells to regulate the cycling status of the most primitive human h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37130b003ca0764e8257d059ca7095be
https://pubmed.ncbi.nlm.nih.gov/1712638
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