Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine

Autor: H Kawasaki, CJ Carrera, LD Piro, A Saven, TJ Kipps, DA Carson

Publikováno v: Blood. 81(3)

The agent 2-chlorodeoxyadenosine (2-CdA) has chemotherapeutic activity in hairy cell leukemia (HCL) and in refractory chronic lymphocytic leukemia (CLL). The cytotoxic activity of 2-CdA requires the intracellular accumulation of 2-CdA nucleotides. De

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ce2dd8dc75ca9edbabeff0520c0e6e
https://pubmed.ncbi.nlm.nih.gov/8094016

Presence of methylthioadenosine phosphorylase (MTAP) in hematopoietic stem/progenitor cells: its therapeutic implication for MTAP (-) malignancies

Autor: Yu J, Batova A, Shao L, Cj, Carrera, alice yu

Publikováno v: Europe PubMed Central

Methylthioadenosine phosphorylase (MTAP) is important for the salvage of adenine and methionine. Recently, we found frequent deletion of MTAP in T-cell acute lymphoblastic leukemia (T-ALL) patients both at diagnosis and at relapse (A. Batova et al.,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a477b3ae884ad4104c8a991bd4f5f3a1
http://europepmc.org/abstract/med/9815702

Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial.

Autor: Mohamed S; Veterans Affairs (VA) New England Mental Illness Research, Education, and Clinical Center, VA Connecticut Healthcare System, West Haven2Yale University School of Medicine, West Haven, Connecticut., Johnson GR; Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven., Chen P; Louis Stokes VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio., Hicks PB; Central Texas Veterans Healthcare System and Department of Psychiatry and Behavioral Science, Texas A&M Health Science Center College of Medicine, Temple6Central Texas Veterans Healthcare System, Temple., Davis LL; Tuscaloosa VA Medical Center, Tuscaloosa, Alabama8University of Alabama School of Medicine, Birmingham., Yoon J; Health Economics Resource Center, VA Palo Alto, Menlo Park, California., Gleason TC; Department of Veterans Affairs, Office of Research and Development, Washington, DC., Vertrees JE; Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, New Mexico., Weingart K; VA San Diego Healthcare System, San Diego, California13University of California, San Diego., Tal I; VA San Diego Healthcare System, San Diego, California., Scrymgeour A; Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, New Mexico., Lawrence DD; Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven., Planeta B; Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven., Thase ME; Philadelphia VA Medical Center, Philadelphia, Pennsylvania., Huang GD; Cooperative Studies Program Central Office, Department of Veterans Affairs Office of Research and Development, Washington, DC., Zisook S; VA San Diego Healthcare System, San Diego, California13University of California, San Diego., Rao SD; VA San Diego Healthcare System, San Diego, California13University of California, San Diego., Pilkinton PD; Tuscaloosa VA Medical Center, Tuscaloosa, Alabama., Wilcox JA; Southern Arizona VA Healthcare System, Tucson., Iranmanesh A; Salem VA Medical Center, Salem, Virginia., Sapra M; Salem VA Medical Center, Salem, Virginia., Jurjus G; Louis Stokes VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio., Michalets JP; Charles George VA Medical Center, Asheville, North Carolina., Aslam M; Cincinnati VA Medical Center, Cincinnati, Ohio., Beresford T; VA Eastern Colorado Healthcare System, Denver., Anderson KD; Kansas City VA Medical Center, Kansas City, Missouri., Fernando R; VA Loma Linda Healthcare System, Loma Linda, California., Ramaswamy S; VA Nebraska Western Iowa Healthcare System, Omaha., Kasckow J; VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania., Westermeyer J; Minneapolis VA Health Care System, Minneapolis, Minnesota., Yoon G; Minneapolis VA Health Care System, Minneapolis, Minnesota., D'Souza DC; Veterans Affairs (VA) New England Mental Illness Research, Education, and Clinical Center, VA Connecticut Healthcare System, West Haven., Larson G; Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin., Anderson WG; Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin., Klatt M; Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin., Fareed A; Atlanta VA Medical Center, Atlanta, Georgia., Thompson SI; Phoenix VA Health Care System, Phoenix, Arizona., Carrera CJ; Phoenix VA Health Care System, Phoenix, Arizona., Williams SS; Central Texas Veterans Healthcare System, Temple., Juergens TM; William S. Middleton Veterans Hospital, Madison, Wisconsin., Albers LJ; Long Beach VA Healthcare System, Long Beach, California., Nasdahl CS; Memphis VA Medical Center, Memphis, Tennessee., Villarreal G; New Mexico VA Healthcare System, Albuquerque., Winston JL; James A Haley VA Hospital, Tampa, Florida., Nogues CA; Bruce W. Carter VA Medical Center, Miami, Florida., Connolly KR; Philadelphia VA Medical Center, Philadelphia, Pennsylvania., Tapp A; VA Puget Sound Health Care System, American Lake/Tacoma, Washington., Jones KA; VA Puget Sound Health Care System, American Lake/Tacoma, Washington., Khatkhate G; Edward Hines Jr VA Hospital, Hines, Illinois., Marri S; Edward Hines Jr VA Hospital, Hines, Illinois., Suppes T; VA Palo Alto Healthcare System, Palo Alto, California., LaMotte J; W.G. Hefner VA Medical Center, Salisbury, North Carolina., Hurley R; W.G. Hefner VA Medical Center, Salisbury, North Carolina., Mayeda AR; Richard L Roudebush VA Medical Center, Indianapolis, Indiana., Niculescu AB 3rd; Richard L Roudebush VA Medical Center, Indianapolis, Indiana., Fischer BA; VA Maryland Healthcare System, Baltimore., Loreck DJ; VA Maryland Healthcare System, Baltimore., Rosenlicht N; San Francisco VA Health Care System, San Francisco, California., Lieske S; San Francisco VA Health Care System, San Francisco, California., Finkel MS; Louis A. Johnson VA Medical Center, Clarksburg, West Virginia., Little JT; Washington DC VA Medical Center.

Publikováno v: JAMA [JAMA] 2017 Jul 11; Vol. 318 (2), pp. 132-145.

A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer.

Autor: Schmid M; Department of Medicine and the Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla 92093, USA., Sen M, Rosenbach MD, Carrera CJ, Friedman H, Carson DA

Publikováno v: Oncogene [Oncogene] 2000 Nov 23; Vol. 19 (50), pp. 5747-54.

Rational design, synthesis and structure-activity relationships of antitumor (E)-2-benzylidene-1-tetralones and (E)-2-benzylidene-1-indanones.

Autor: Shih H; The Sam and Rose Stein Institute for Research on Aging and Department of Medicine, University of California San Diego, La Jolla 92093-0663, USA. hshih@ucsd.edu, Deng L, Carrera CJ, Adachi S, Cottam HB, Carson DA

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2000 Mar 06; Vol. 10 (5), pp. 487-90.