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The state of GPCR research in 2004

Publikováno v: Bartfai, T, Benovic, J L, Bockaert, J, Bond, R A, Bouvier, M, Christopoulos, A, Civelli, O, Devi, L A, George, S R, Inui, A, Kobilka, B, Leurs, R, Neubig, R, Pin, J P, Quirion, R, Roques, B P, Sakmar, T P, Seifert, R, Stenkamp, R E & Strange, P G 2004, ' The state of GPCR research in 2004 ', Nature Reviews Drug Discovery, vol. 3, no. 7, pp. 574-626 . https://doi.org/10.1038/nrd1458
Nature Reviews Drug Discovery, 3(7), 574-626. Nature Publishing Group

List of questions G-protein-coupled receptors (GPCRs) comprise the largest single class of cell-surface receptors, and have a history of being excellent therapeutic targets for a number of diseases. Yet several fundamental questions remain regarding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15599174a7f720e8551508d857b37150
https://research.vu.nl/en/publications/5f3edb59-aa3b-4e43-8d42-bbe65a0b6317

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Identification of Neuropeptide Receptors Expressed by Melanin-Concentrating Hormone Neurons

Autor: Parks, GS, Wang, L, Wang, Z, Civelli, O

Publikováno v: JOURNAL OF COMPARATIVE NEUROLOGY, vol 522, iss 17
The Journal of comparative neurology, vol 522, iss 17
Parks, GS; Wang, L; Wang, Z; & Civelli, O. (2014). Identification of Neuropeptide Receptors Expressed by Melanin-Concentrating Hormone Neurons. JOURNAL OF COMPARATIVE NEUROLOGY, 522(17), 3817-3833. doi: 10.1002/cne.23642. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2zn7k3xd
Parks, GS; Wang, L; Wang, Z; & Civelli, O. (2014). Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons. Journal of Comparative Neurology, 522(17), 3817-3833. doi: 10.1002/cne.23642. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9dz7g4qd

© 2014 Wiley Periodicals, Inc. Melanin-concentrating hormone (MCH) is a 19-amino-acid cyclic neuropeptide that acts in rodents via the MCH receptor 1 (MCHR1) to regulate a wide variety of physiological functions. MCH is produced by a distinct popula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d862d79f984fe7df44822ae4816051cf
https://escholarship.org/uc/item/2zn7k3xd

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Akademický článek

The melanin-concentrating hormone (MCH) system in an animal model of depression-like behavior

Autor: García-Fuster, M.J., Parks, G.S., Clinton, S.M., Watson, S.J., Akil, H., Civelli, O.

Publikováno v: In European Neuropsychopharmacology August 2012 22(8):607-613

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Orphan GPCR research

Autor: Chung, S, Funakoshi, T, Civelli, O

Orphan G protein-coupled receptors (GPCRs) are receptors lacking endogenous ligands. Found by molecular biological analyses, they became the roots of reverse pharmacology, in which receptors are attempted to be matched to potential transmitters. Late

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40ca0d74c83990ecb6127eb59ad5946f
https://europepmc.org/articles/PMC2268047/

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