Výsledky vyhledávání - "Civeira, M.P. (María Pilar)"

Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection

Autor: Larrea, E. (Esther), Riezu-Boj, J.I. (José Ignacio), Gil-Guerrero, L. (Lucía), Casares, N. (Noelia), Aldabe, R. (Rafael), Sarobe, P. (Pablo), Civeira, M.P. (María Pilar), Heeney, J.L. (Jonathan L.), Rollier, C.S. (Christine S.), Verstrepen, B.E. (Babs E.)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Indoleamine 2,3-dioxygenase (IDO) is induced by proinflammatory cytokines and by CTLA-4-expressing T cells and constitutes an important mediator of peripheral immune tolerance. In chronic hepatitis C, we found upregulation of IDO expression in the li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f738e5fa112504838439fee31fe04b3a
https://hdl.handle.net/10171/21602

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Hepatitis C virus infection of primary tupaia hepatocytes leads to selection of quasispecies variants, induction of interferon-stimulated genes and NF-kappaB nuclear translocation

Autor: Guitart, A. (Anunciata), Riezu-Boj, J.I. (José Ignacio), Elizalde, E. (Edurne), Larrea, E. (Esther), Berasain, C. (Carmen), Aldabe, R. (Rafael), Civeira, M.P. (María Pilar), Prieto, J. (Jesús)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Systems for in vitro culture of Hepatitis C virus (HCV) are essential tools to analyse virus-cell interactions and to investigate relevant pathophysiological aspects of HCV infection. Although the HCV replicon methodology has increased our understand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::068d174567138b507e83c14f5125234b
https://hdl.handle.net/10171/23243

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Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5

Autor: Larrea, E. (Esther), Alberdi, A. (A.), Castelruiz, Y. (Yurdana), Boya, P. (Patricia), Civeira, M.P. (María Pilar), Prieto, J. (Jesús)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Interferon (IFN)-alpha is a family of antiviral proteins encoded by different genes. The biological significance of the existence of various IFN-alpha subtypes is not clear. We have investigated the interferon system in chronic hepatitis C virus (HCV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1dd70d24cf14c0060c13f42ae9824833
https://hdl.handle.net/10171/23330

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Nuclear factor-kappa B in the liver of patients with chronic hepatitis C: decreased RelA expression is associated with enhanced fibrosis progression

Autor: Boya, P. (Patricia), Larrea, E. (Esther), Sola, J. (Josu), Majano, P.L. (Pedro Lorenzo), Jimenez, C. (Carlos), Civeira, M.P. (María Pilar), Prieto, J. (Jesús)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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The mechanisms of liver damage in chronic hepatitis C virus (HCV) infection are poorly understood. The transcription factor, nuclear factor-kappa B (NF-kappa B), regulates the expression of genes involved in apoptosis, inflammation, and antiviral res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::15311b2f77a9b4b5b730f0f12227d074
https://hdl.handle.net/10171/23300

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Transmission of hepatitis C virus infection to tree shrews

Autor: Xie, Z.C. (Zhi-Chun), Riezu-Boj, J.I. (José Ignacio), Lasarte, J.J. (Juan José), Guillen, J. (Javier), Su, J.H. (Jie-Han), Civeira, M.P. (María Pilar), Prieto, J. (Jesús)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Although hepatitis C virus (HCV) infection can be reproduced in chimpanzees, these animals are rare and expensive. Tree shrews (tupaias) are small animals, closely related to primates, which adapt easily to a laboratory environment. In this work we h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bfb3bedf4ddfa36738edc5ea2624c89f
https://hdl.handle.net/10171/21718

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Cellular immunity to hepatitis C virus core protein and the response to interferon in patients with chronic hepatitis C

Autor: Lasarte, J.J. (Juan José), Garcia-Granero, M. (Marta), Lopez, A. (Ascensión), Casares, N. (Noelia), Garcia, N. (Nicolás), Civeira, M.P. (María Pilar), Borras-Cuesta, F. (Francisco), Prieto, J. (Jesús)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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To investigate the involvement of T-cell response against hepatitis C virus (HCV) antigens in viral clearance after interferon therapy, we measured interleukin-2 (IL-2) production by peripheral mononuclear cells in response to HCV core in patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::dd1dfbae19d984eb743dec1065e0f261
https://hdl.handle.net/10171/21719

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Risk factors for recurrence of hepatitis C after liver transplantation

Autor: Herrero, J.I. (José Ignacio), Peña, A. (Andrés) de la, Quiroga, J. (Jorge), Sangro, B. (Bruno), Garcia, N. (Nicolás), Sola, J. (Josu), Álvarez-Cienfuegos, J. (Javier), Civeira, M.P. (María Pilar), Prieto, J. (Jesús)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Recurrent hepatitis C is a frequent complication after liver transplantation for hepatitis C virus– related cirrhosis, but risk factors related to its development remain ill defined. Twenty-three patients receiving a primary liver graft for hepatit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::df6d3935b9b3981a9ec7227e6a744383
https://hdl.handle.net/10171/23506

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Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C

Autor: Gavier, B. (B.), Martinez-Gonzalez, M.A. (Miguel Ángel), Riezu-Boj, J.I. (José Ignacio), Lasarte, J.J. (Juan José), Garcia, N. (Nicolás), Civeira, M.P. (María Pilar), Prieto, J. (Jesús)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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BACKGROUND & AIMS: In chronic hepatitis C, interferon alfa induces sustained remission in less than 30% of treated patients. The aim of this study is to analyze viral status early after initiation interferon therapy as a predictor of treatment outcom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::58043fd99546239b6de924f150c9427a
https://hdl.handle.net/10171/21677

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CD4-modified synthetic peptides containing phenylalanine inhibit HIV-1 infection in vitro

Autor: Lasarte, J.J. (Juan José), Sarobe, P. (Pablo), Golvano, J.J. (José Javier), Prieto, I. (Isidro), Civeira, M.P. (María Pilar), Gullon, A. (Arturo), Sarin, P.S. (Prem S.), Prieto, J. (Jesús), Borras-Cuesta, F. (Francisco)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Phenylalanine-containing peptides from CD4 were synthesized based on chemical similarity with active CD4(81-92)-benzylated peptides. The synthetic peptide FYIFFVEDQKEEDD blocked the binding of gp120 to CD4 and inhibited 50% human immunodeficiency vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2abe826967ac1a1b409dc05a88c3038f
https://hdl.handle.net/10171/21653

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