INDY as a Therapeutic Target for Cardio-Metabolic Disease

Autor: Dominik Pesta, Jens Jordan

Publikováno v: Metabolites, Vol 12, Iss 3, p 244 (2022)

Decreased expression of the plasma membrane citrate transporter INDY (acronym I’m Not Dead, Yet) promotes longevity and protects from high-fat diet- and aging-induced metabolic derangements. Preventing citrate import into hepatocytes by different s

Externí odkaz: https://doaj.org/article/d3a8760d34d241e3b354483bdb6e737b

Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD

Autor: Zhiyu Li, Qiushuang Sun, Qun Niu, Yating Guo, Fang Huang, Xiaonan Li, Zhixia Qiu, Ning Li, Jia Liu, Yu Zhuang

Publikováno v: Journal of Agricultural and Food Chemistry. 69:8714-8725

Upregulated de novo lipogenesis (DNL) plays a pivotal role in the progress of the nonalcoholic fatty liver disease (NAFLD). Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af680ab2f05a7f217778c8f40142c70
https://doi.org/10.1021/acs.jafc.1c03105

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Expression of OsFRDL1, a MATE gene family member, indicates its involvement in aluminum response in rice

Autor: Camila Pegoraro, Antonio Costa de Oliveira, Vívian Ebeling Viana, Rogério Oliveira de Sousa, Denise Colares de Oliveira

Publikováno v: Agropecuária Catarinense, Vol 33, Iss 3 (2020)
Agropecuária Catarinense Journal; Vol. 33 No. 3 (2020); 53-59
Agropecuária Catarinense; v. 33 n. 3 (2020); 53-59
Agropecuária Catarinense
Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina (Epagri)
instacron:EPAGRI

In soils under acidic conditions, Aluminum (Al) is solubilized to its ionic form, which is toxic to plants. Al rapidly inhibits root elongation, water and nutrient uptake, resulting in crop yield reduction. Members of the MATE family are responsible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc5c92d34b5b03ac4e97a638eabf828
https://doi.org/10.52945/rac.v33i3.1032

Acetyl-CoA derived from hepatic mitochondrial fatty acid β-oxidation aggravates inflammation by enhancing p65 acetylation

Autor: Jianlong Du, Qiuchi Chen, Qinghui Ai, Zengqi Zhao, Wei Fang, Kun Cui, Kangsen Mai, Qiang Chen

Publikováno v: iScience, Vol 24, Iss 11, Pp 103244-(2021)
iScience

Summary Acetylation coordinates many biological processes to ensure cells respond appropriately to nutrients. However, how acetylation regulates lipid surplus-induced inflammation remains poorly understood. Here, we found that a high-fat diet (HFD) e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b34bbbb0042bb7d26337ea112c95ed
http://www.sciencedirect.com/science/article/pii/S2589004221012128