Enhanced anticancer potency with reduced nephrotoxicity of newly synthesized platin-based complexes compared with cisplatin

Autor: Roya Salehi, Selda Abyar, Fatemeh Ramazani, Ali Akbar Khandar, Seyed Abolfazl Hosseini-Yazdi, Jonathan M. White, Mahdi Edalati, Houman Kahroba, Mehdi Talebi

Publikováno v: Scientific Reports, 12(1):8316. Nature Publishing Group

As a platinum-containing anticancer drug, cisplatin is the keystone for treating many malignancies. Nephrotoxicity is the main dose-limiting toxicity, and several hydration therapies and supplementary strategies are utilized to reduce cisplatin-induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a783f131b73a3e95ed6dd2ae469153
https://cris.maastrichtuniversity.nl/en/publications/618bcb5d-8e78-45c2-8ee9-629b7cbbdb17

Usefulness of current candidate genetic markers to identify childhood cancer patients at risk for platinum-induced ototoxicity: Results of the European PanCareLIFE cohort study

Autor: Thorsten Langer, Eva Clemens, Linda Broer, Lara Maier, Andre G. Uitterlinden, Andrica C. H. de Vries, Martine van Grotel, Saskia F.M. Pluijm, Harald Binder, Benjamin Mayer, Annika von dem Knesebeck, Julianne Byrne, Eline van Dulmen-den Broeder, Marco Crocco, Desiree Grabow, Peter Kaatsch, Melanie Kaiser, Claudia Spix, Line Kenborg, Jeanette Falck Winther, Catherine Rechnitzer, Henrik Hasle, Tomas Kepak, Anne-Lotte F. van der Kooi, Leontien C. Kremer, Jarmila Kruseova, Stefan Bielack, Benjamin Sorg, Stefanie Hecker-Nolting, Claudia E. Kuehni, Marc Ansari, Martin Kompis, Heleen van der Pal, Ross Parfitt, Dirk Deuster, Peter Matulat, Amelie Tillmanns, Wim J. E. Tissing, Jörn D. Beck, Susanne Elsner, Antoinette am Zehnhoff-Dinnesen, Marry M. van den Heuvel-Eibrink, Oliver Zolk, PanCareLIFE Consortium Group

Publikováno v: European Journal of Cancer, 138, 212-224. ELSEVIER SCI LTD
Langer, T, Clemens, E, Broer, L, Maier, L, Uitterlinden, A G, de Vries, A C H, van Grotel, M, Pluijm, S F M, Binder, H, Mayer, B, von dem Knesebeck, A, Byrne, J, van Dulmen-den Broeder, E, Crocco, M, Grabow, D, Kaatsch, P, Kaiser, M, Spix, C, Kenborg, L, Winther, J F, Rechnitzer, C, Hasle, H, Kepak, T, van der Kooi, A L F, Kremer, L C, Kruseova, J, Bielack, S, Sorg, B, Hecker-Nolting, S, Kuehni, C E, Ansari, M, Kompis, M, van der Pal, H, Parfitt, R, Deuster, D, Matulat, P, Tillmanns, A, Tissing, W J E, Beck, J D, Elsner, S, am Zehnhoff-Dinnesen, A, van den Heuvel-Eibrink, M M, Zolk, O & PanCareLIFE Consortium 2020, ' Usefulness of current candidate genetic markers to identify childhood cancer patients at risk for platinum-induced ototoxicity : Results of the European PanCareLIFE cohort study ', European Journal of Cancer, vol. 138, pp. 212-224 . https://doi.org/10.1016/j.ejca.2020.07.019
European Journal of Cancer, 138, 212-224. Elsevier Limited
European Journal of Cancer, 138, 212-224. Elsevier Ltd.
European Journal of Cancer, 138, 212-224. Pergamon
European journal of cancer, Vol. 138 (2020) pp. 212-224
PanCareLIFE Consortium 2020, ' Usefulness of current candidate genetic markers to identify childhood cancer patients at risk for platinum-induced ototoxicity: Results of the European PanCareLIFE cohort study ', European Journal of Cancer, vol. 138, pp. 212-224 . https://doi.org/10.1016/j.ejca.2020.07.019

Background Irreversible sensorineural hearing loss is a common side effect of platinum treatment with the potential to significantly impair the neurocognitive, social and educational development of childhood cancer survivors. Genetic association stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d8f2db88f78dbcfc6e239adea5886a
https://research.rug.nl/en/publications/3dda98e0-06d0-4a16-ad8d-a2a180e05ef0

Preoperative chemotherapy and radiotherapy concomitant to cetuximab in resectable stage IIIB NSCLC: a multicentre phase 2 trial (SAKK 16/08)

Autor: Curioni-Fontecedro, Alessandra, Perentes, Jean Yannis, Gelpke, Hans, Xyrafas, Alexandros, Bouchaab, Hasna, Mach, Nicolas, Matzinger, Oscar, Stojcheva, Nina, Frueh, Martin, Weder, Walter, Cathomas, Richard, Gargiulo, Piera, Bubendorf, Lukas, Pless, Miklos, Betticher, Daniel, Peters, Solange, Swiss Group of Clinical Cancer Research (SAKK)

Publikováno v: British journal of cancer, vol. 120, no. 10, pp. 968-974
British Journal of Cancer, Vol. 120, No 10 (2019) pp. 968-974
British Journal of Cancer

Neoadjuvant chemotherapy (CT) followed by radiotherapy (RT) and surgery showed a median survival of 28.7 months in resectable stage IIIB non-small-cell lung cancer (NSCLC) patients (pts). Here, we evaluate the impact of concomitant cetuximab to the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505dd02a974a25c299fb36ed60ff60ed
https://serval.unil.ch/resource/serval:BIB_6DA91E6BDAAE.P001/REF.pdf

Impact of garlic (Allium sativum) oil on cisplatin-induced hepatorenal biochemical and histopathological alterations in rats

Autor: Abdel-Daim, Mohamed M. ^{a, b, ⁎}, Abdel-Rahman, Haidy G. ^c, Dessouki, Amina A. ^d, El-Far, Ali H. ^e, Khodeer, Dina M. ^f, Bin-Jumah, May ^g, Alhader, Mosaed S. ^h, Alkahtani, Saad ^a, Aleya, Lotfi ^{i, ⁎}

Publikováno v: In Science of the Total Environment 25 March 2020 710

Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity

Autor: Jan D'hooge, Peter Carmeliet, Myriam Baes, Andrey Anisimov, Massimiliano Mazzone, Carmen Roncal, Lorenzo Veschini, Yannick Jönsson, Daniela Dettori, Veronica Finisguerra, Rodrigo Leite de Oliveira, Evelyne Tack, Sofie Deschoemaeker, Matthias Hofmann, Annelies Peeters, Yukiji Takeda, Koen Debackere, Anne-Theres Henze, Kari Alitalo

Publikováno v: Cancer Cell

SummaryThe success of chemotherapy in cancer treatment is limited by scarce drug delivery to the tumor and severe side-toxicity. Prolyl hydroxylase domain protein 2 (PHD2) is an oxygen/redox-sensitive enzyme that induces cellular adaptations to stres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5a2c434c8b0256ab8a5426975ff3c1
https://doi.org/10.1016/j.ccr.2012.06.028