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aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2–mediated SphK1-S1PR1-Akt signaling axis

Autor: Luisa J. Coronel, Hemal H. Patel, Neil Grimsey, Cisneros-Aguirre M, Mark A. Lawson, Olivia Molinar-Inglis, Anand Patwardhan, Gomez-Menzies Pk, JoAnn Trejo, Dequina A. Nicholas, Cierra A. Birch, Huilan Lin, Brian H. Chen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 49
Proc Natl Acad Sci U S A

Endothelial dysfunction is associated with vascular disease and results in disruption of endothelial barrier function and increased sensitivity to apoptosis. Currently, there are limited treatments for improving endothelial dysfunction. Activated pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3087ad0fccc2054ddfb4ef55a58eef
https://doi.org/10.1073/pnas.2106623118

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An optimized fractionation method reveals insulin-induced membrane surface localization of GLUT1 to increase glycolysis in LβT2 cells.

Autor: Molinar-Inglis O; Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Wiggins K; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, 92697, USA., Varma A; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, 92697, USA., Del Mundo Z; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, 92697, USA., Adame JM; Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Cozzo A; Department of Obstetrics, Gynecology and Reproductive Sciences, and Center for Reproductive Science and Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Muñoz O; Department of Obstetrics, Gynecology and Reproductive Sciences, and Center for Reproductive Science and Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Le UV; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, 92697, USA., Trinh D; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, 92697, USA., Garcia AC; Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Cisneros-Aguirre M; Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Gonzalez Ramirez ML; Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Keyes J; Department of Biology, Pennsylvania State University Erie, The Behrend College, Erie, PA, USA., Zhang J; Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Lawson MA; Department of Obstetrics, Gynecology and Reproductive Sciences, and Center for Reproductive Science and Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Trejo J; Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Nicholas DA; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, 92697, USA. Electronic address: dequinaa@uci.edu.

Publikováno v: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2024 Oct 29; Vol. 595, pp. 112405. Date of Electronic Publication: 2024 Oct 29.