Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.

Autor: DeRatt LG; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Zhang Z; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Pietsch C; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Cisar JS; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Zhang X; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Wang W; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Tanner A; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Matico R; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Shaffer P; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Jacoby E; Janssen Research and Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Kazmi F; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Shukla N; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Bush TL; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Patrick A; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Philippar U; Janssen Research and Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Attar R; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Edwards JP; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Kuduk SD; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 11254-11272. Date of Electronic Publication: 2024 Jun 18.

N -Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.

Autor: Cisar JS; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Pietsch C; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., DeRatt LG; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Jacoby E; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Kazmi F; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Keohane C; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Legenski K; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Matico R; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Shaffer P; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Simonnet Y; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Tanner A; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Wang CY; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Wang W; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Attar R; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Edwards JP; Janssen Research and Development, San Diego, California 92121, United States., Kuduk SD; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Aug 25; Vol. 65 (16), pp. 11241-11256. Date of Electronic Publication: 2022 Aug 04.

Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators.

Autor: Clapper JR; Abide Therapeutics, San Diego, California., Henry CL; Abide Therapeutics, San Diego, California., Niphakis MJ; Abide Therapeutics, San Diego, California., Knize AM; Abide Therapeutics, San Diego, California., Coppola AR; Abide Therapeutics, San Diego, California., Simon GM; Abide Therapeutics, San Diego, California., Ngo N; Abide Therapeutics, San Diego, California., Herbst RA; Abide Therapeutics, San Diego, California., Herbst DM; Abide Therapeutics, San Diego, California., Reed AW; Abide Therapeutics, San Diego, California., Cisar JS; Abide Therapeutics, San Diego, California., Weber OD; Abide Therapeutics, San Diego, California., Viader A; Abide Therapeutics, San Diego, California., Alexander JP; Abide Therapeutics, San Diego, California., Cunningham ML; Abide Therapeutics, San Diego, California., Jones TK; Abide Therapeutics, San Diego, California., Fraser IP; Abide Therapeutics, San Diego, California., Grice CA; Abide Therapeutics, San Diego, California., Ezekowitz RAB; Abide Therapeutics, San Diego, California., O'Neill GP; Abide Therapeutics, San Diego, California., Blankman JL; Abide Therapeutics, San Diego, California jackie@abidetx.com.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2018 Dec; Vol. 367 (3), pp. 494-508. Date of Electronic Publication: 2018 Oct 10.

Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.

Autor: Lun S; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Guo H, Adamson J, Cisar JS, Davis TD, Chavadi SS, Warren JD, Quadri LE, Tan DS, Bishai WR

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Oct; Vol. 57 (10), pp. 5138-40. Date of Electronic Publication: 2013 Jul 15.

Fully functionalized small-molecule probes for integrated phenotypic screening and target identification.

Autor: Cisar JS; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA., Cravatt BF

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2012 Jun 27; Vol. 134 (25), pp. 10385-8. Date of Electronic Publication: 2012 Jun 13.