Disruption of perinatal myeloid niches impacts the aging clock of pancreatic β cells.

Autor: O'Sell J; Department of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA., Cirulli V; Department of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA., Pardike S; Department of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA., Aare-Bentsen M; Department of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA., Sdek P; Department of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA., Anderson J; Department of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA., Hailey DW; Department of Laboratory Medicine and Pathology, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA., Regier MC; Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA., Gharib SA; Computational Medicine Core at Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA 98109, USA., Crisa L; Department of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA.

Publikováno v: IScience [iScience] 2024 Aug 07; Vol. 27 (9), pp. 110644. Date of Electronic Publication: 2024 Aug 07 (Print Publication: 2024).

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Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis.

Autor: Wei X; Department of Urology, University of Washington, 850 Republican Street, Seattle, WA 98109, USA., Zhang L; Department of Urology, University of Washington, 850 Republican Street, Seattle, WA 98109, USA., Zhang Y; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Cooper C; Alpenglow Biosciences, Inc., Seattle, WA 98103, USA., Brewer C; Alpenglow Biosciences, Inc., Seattle, WA 98103, USA., Tsai CF; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Wang YT; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Glaz M; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98109, USA., Wessells HB; Department of Urology, University of Washington, 850 Republican Street, Seattle, WA 98109, USA., Que J; Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA., Titus MA; Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston TX 77030, USA., Cirulli V; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA., Glaser A; Department of Mechanical Engineering, University of Washington, Seattle, WA 98109, USA., Liu T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Reder NP; Alpenglow Biosciences, Inc., Seattle, WA 98103, USA., Creighton CJ; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Xin L; Department of Urology, University of Washington, 850 Republican Street, Seattle, WA 98109, USA; Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston TX 77030, USA. Electronic address: xin18@uw.edu.

Publikováno v: Cell reports [Cell Rep] 2022 Sep 06; Vol. 40 (10), pp. 111313.

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